Article
Microbiology
Luis M. Amezcua-Guerra, Carlos A. Guzman-Martin, Isela Montufar-Robles, Rashidi Springall, Adrian Hernandez-Diazcouder, Rosa Elda Barbosa-Cobos, Fausto Sanchez-Munoz, Julian Ramirez-Bello
Summary: This study investigated the impact of the CD147 gene rs8259T>A single nucleotide variant on individuals with COVID-19 in Mexico. The results suggest that the CD147 rs8259T>A variant is significantly associated with susceptibility to COVID-19, acting as a risk factor.
Article
Medicine, General & Internal
Ying-Hao Wen, Wei-Tzu Lin, Wei-Ting Wang, Ding-Ping Chen
Summary: Transfusion reactions may be associated with CD28 and CTLA4 gene polymorphisms, with specific SNPs linked to an increased risk. This study found an association between the rs3181097 polymorphism of CD28 and transfusion reactions, potentially regulating immune response by decreasing CD28 protein expression.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Genetics & Heredity
Marcos Jesse Abrahao Silva, Caroliny Soares Silva, Marcelo Cleyton da Silva Vieira, Pabllo Antonny Silva dos Santos, Cristiane Cunha Frota, Karla Valeria Batista Lima, Luana Nepomuceno Gondim Costa Lima
Summary: This article conducted a systematic review and meta-analysis to investigate the association between a polymorphism of the Toll-like receptor 3 (TLR3) gene and susceptibility to infections. The results showed a significant association between the TLR3 rs3775291 polymorphism and infection risk, particularly with a higher risk in the Asian and American continents.
Review
Food Science & Technology
Christina Holzapfel, Melanie Waldenberger, Stefan Lorkowski, Hannelore Daniel
Summary: This article summarizes the evidence for the impact of genetic and epigenetic factors on diseases such as obesity, metabolic syndrome, and diabetes, and evaluates the effectiveness of genotype-based nutrition advice. The study finds that there is generally a lack of evidence for the success of gene-based dietary recommendations, suggesting the need for future personalized nutrition solutions to incorporate more phenotypic measures and individualized tools.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Medicine, General & Internal
Meei-Maan Wu, Fang- Hsieh, Ling- Hsu, Te-Chang Lee, Hung-Yi Chiou, Chien-Jen Chen
Summary: The study investigated the impact of HO-1 gene variants on liver cancer risk in humans, finding a significant association between the S/S genotype and liver cancer risk, as well as a higher percentage of subjects with abnormal AFP levels in the S/S genotype group. There were significant percentages of cirrhosis among groups who carried S-alleles.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Ming-Dong Wang, Jing Tian, John H. Zhang, Shun-Ying Zhao, Ming-Jing Song, Zhan-Xiang Wang
Summary: This study aimed to investigate the relationship between genetic polymorphisms of the human galectin-7 gene and the risk of non-traumatic intracerebral hemorrhage (ICH) stroke. Through transgenic mouse experiments and gene genotyping analysis, two SNP loci associated with ICH risk were identified. This study is the first to genotype the galectin-7 promoter in patients with hemorrhagic stroke.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Genetics & Heredity
Emilia Burada, Maria-Magdalena Rosu, Raluca Elena Sandu, Florin Burada, Mihai Gabriel Cucu, Ioana Streata, Bianca Petre-Mandache, Gabriela Popescu-Hobeanu, Monica-Laura Cara, Anca-Maria Tuca, Elena Pinosanu, Carmen Valeria Albu
Summary: This study found that miR-499a rs3746444 A>G may be associated with susceptibility to both type 2 diabetes and diabetic polyneuropathy in the Romanian population. The carriers of the GG genotype and G allele had a higher prevalence among the patients.
Article
Dentistry, Oral Surgery & Medicine
L. A. Chisini, F. D. S. Costa, B. L. Horta, L. Tovo-Rodrigues, F. F. Demarco, M. B. Correa
Summary: This research investigates the association between dental caries trajectory and rs307355 (TAS1R3) and rs35874116 (TAS1R2), as well as the epistatic association between rs307355 (TAS1R3) and rs35874116 (TAS1R2). A representative sample of 5,914 individuals from the 1982 Pelotas birth cohort was prospectively studied. Group-based trajectory modeling identified different groups with similar dental caries trajectories throughout life. Genetic material was collected for genotyping rs307355 (TAS1R3) and rs35874116 (TAS1R2). The study found that the genotype and allele of rs307355 (TAS1R3) were positively associated with the trajectory of decayed and missing dental components. Epistatic interaction between rs307355 and rs35874116 may increase the decayed caries trajectory.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Immunology
Hong Yang, Jie Song, Aole Li, Linshuoshuo Lv, Xiaohui Sun, Yingying Mao, Ding Ye
Summary: Using Mendelian randomization, this study found an inverse association between serum folate level and vitiligo risk, as well as a positive association between vitamin B-12 and inflammatory bowel disease risk. However, the association between vitamin B-12 and inflammatory bowel disease did not remain significant after Bonferroni correction. Further research is needed to clarify the possible association between vitamin B-12 and inflammatory bowel disease risk.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mateusz Sypniewski, Zbigniew J. Krol, Joanna Szyda, Elzbieta Kaja, Magdalena Mroczek, Tomasz Suchocki, Adrian Lejman, Maria Stepien, Piotr Topolski, Maciej Dabrowski, Krzysztof Kotlarz, Angelika Aplas, Michal Wasiak, Marzena Wojtaszewska, Pawel Zawadzki, Agnieszka Pawlak, Robert Gil, Paula Dobosz, Joanna Stojak
Summary: This study identified genetic variants related to cardiovascular and pulmonary diseases that may be correlated with severe outcomes of COVID-19 in a Polish cohort.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Naixia Ren, Bo Li, Qingqing Liu, Lele Yang, Xiaodan Liu, Qilai Huang
Summary: This study describes a new method based on a dinucleotide-tag reporter system for parallel analysis of gene regulatory elements, with minimized bias and improved robustness. The researchers applied this system to evaluate SNPs associated with prostate cancer risk and identified potential regulatory functions of SNPs in two cell lines.
BIOTECHNOLOGY JOURNAL
(2022)
Article
Immunology
Shuwen Wang, Xiaoyu Zhang, Shaoqiu Leng, Qirui Xu, Zi Sheng, Yanqi Zhang, Jie Yu, Qi Feng, Ming Hou, Jun Peng, Xiang Hu
Summary: This study suggests that immune checkpoint-related SNPs, especially CD28 rs1980422, may be genetic factors associated with the development and treatment of ITP patients. Additionally, variants of PD1, DNAM1, LAG3, and ICOS play various roles in the severity of ITP and corticosteroid-resistance.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Kae-Woei Liang, Wen-Jane Lee, Wen-Lieng Lee, Jen-Pey Wu, Wayne H-H Sheu
Summary: The study found that patients with shorter (GT)(n) repeats in the HMOX1 gene promoter had a negative correlation with death events in CAD patients with abnormal EF. The S allele, higher EF, and revascularization with PCI were all negatively associated with all-cause death in subjects with CAD and abnormal EF.
Article
Chemistry, Physical
Wojciech Wegner, Tomasz Jaron
Summary: Three novel organic derivatives of lanthanide borohydrides, n-But(4)NRE(BH4)(4) (TBAREB), RE = Ho, Tm, Yb, have been prepared using mechanochemical synthesis and purified via solvent extraction. Crystallographic studies revealed two polymorphic forms, alpha- and beta-TBAREB, adopting monoclinic and orthorhombic unit cells, respectively. Thermal decomposition of these compounds was investigated using TGA/DSC measurements, analysis of gaseous products with mass spectrometry, and analysis of solid decomposition products with PXRD.
Article
Orthopedics
Adam Biczo, Ferenc Bereczki, Kristof Koch, Peter Pal Varga, Genodisc Consortium, Aron Lazary
Summary: This study investigated the associations of IL6 and IL1B gene polymorphisms with the long-term outcome of degenerative lumbar spine surgeries. The results showed that inflammatory cytokines played an important role in pain improvement, patient reported outcome, and preoperative depression levels after surgery. IL6 and IL1B gene variants were also associated with preoperative depression, somatization, and subsequent surgery. Understanding the complexity of patients' long-term well-being is crucial in treating chronic diseases and their associated mental illnesses, and further research is needed to explore the simultaneous treatment of chronic physical and mental illnesses.
BMC MUSCULOSKELETAL DISORDERS
(2022)