RAS-Driven Macropinocytosis of Albumin or Dextran Reveals Mutation-Specific Target Engagement of RAS p.G12C Inhibitor ARS-1620 by NIR-Fluorescence Imaging

The Frequency of Ras Mutations in Cancer

(2020) Ian A. Prior et al.   CANCER RESEARCH

Quicker, deeper and stronger imaging: A review of tumor-targeted, near-infrared fluorescent dyes for fluorescence guided surgery in the preclinical and clinical stages

(2020) Jianhua Jiao et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

(2019) Jude Canon et al.   NATURE

The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients

(2019) Jill Hallin et al.   Cancer Discovery

The impact of oncogenic RAS on redox balance and implications for cancer development

(2019) Jonathan K. M. Lim et al.   Cell Death & Disease

DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters

(2019) Margie N. Sutton et al.   Cell Reports

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

(2018) Matthew R. Janes et al.   CELL

KRAS G12C NSCLC Models Are Sensitive to Direct Targeting of KRAS in Combination with PI3K Inhibition

(2018) Sandra Misale et al.   CLINICAL CANCER RESEARCH

Direct inhibition of RAS: Quest for the Holy Grail?

(2017) Russell Spencer-Smith et al.   SEMINARS IN CANCER BIOLOGY

Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer

(2017) Maria Victoria Recouvreux et al.   Frontiers in Endocrinology

An engineered protein antagonist of K-Ras/B-Raf interaction

(2017) Monique J. Kauke et al.   Scientific Reports

Inhibition of RAS function through targeting an allosteric regulatory site

(2016) Russell Spencer-Smith et al.   Nature Chemical Biology

Inflammation as a driver and vulnerability of KRAS mediated oncogenesis

(2016) Shunsuke Kitajima et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Loss of expression of the recycling receptor, FcRn, promotes tumor cell growth by increasing albumin consumption

(2016) Rafal Swiercz et al.   Oncotarget

Optical imaging probes in oncology

(2016) Cristina Martelli et al.   Oncotarget

Alternative Fuels for Cancer Cells

(2015) Melissa M. Keenan et al.   CANCER JOURNAL

Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

(2015) Mark A. Feitelson et al.   SEMINARS IN CANCER BIOLOGY

Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes

(2015) Ikuhiko Nakase et al.   Scientific Reports

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

(2014) Xiaomin Yi et al.   International Journal of Nanomedicine

Determining the macropinocytic index of cells through a quantitative image-based assay

(2014) Cosimo Commisso et al.   Nature Protocols

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction

(2013) F. Shima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Ras–effector interactions by cyclic peptides

(2012) Xianghong Wu et al.   MedChemComm