Journal
MOLECULAR AND CELLULAR BIOCHEMISTRY
Volume 477, Issue 3, Pages 915-925Publisher
SPRINGER
DOI: 10.1007/s11010-021-04334-8
Keywords
Alzheimer; Protein degradation; The ubiquitin-proteasome system; Autophagy
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Funding
- PAIP (PAIP) [5000-9105]
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This review investigates the altered pathways involved in proteostasis in AD, suggesting that studying these pathways is critical for identifying new biomarkers and target molecules for AD.
Alzheimer's disease (AD) is the most common type of dementia associated with age-related neurodegeneration. Alteration of several molecular mechanisms has been correlated with the progression of AD. In recent years, dysregulation of proteostasis-associated pathways has emerged as a potential risk factor for neurodegenerative diseases. This review investigated the ubiquitin-proteasome system, lysosome-associated degradation, endoplasmic-reticulum-associated degradation, and the formation of advanced glycation end products. These pathways involved in proteostasis have been reported to be altered in AD, suggesting that their study may be critical for identifying new biomarkers and target molecules for AD.
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