Article
Biochemical Research Methods
Abdellah Muhammed, Ahmed Hussen, Takashi Kaneta
Summary: The study demonstrated the speciation of chromium using mu-PADs, allowing for the colorimetric determination of hexavalent and trivalent chromium. The method offers a rapid and accurate analysis of chromium species, with good agreement to results obtained via ICP-OES. This approach has the potential for widespread application in developing countries facing environmental pollution and limited access to sophisticated instruments.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Jaruwan Mettakoonpitak, Kanokwan Khongsoun, Nithiya Wongwan, Supaporn Kaewbutdee, Atitaya Siripinyanond, Araya Kuharuk, Charles S. Henry
Summary: The introduction of screen-printed biodegradable polycaprolactone (PCL) as a simple, low-cost, and non-toxic alternative approach to create microfluidic paper-based analytical devices (μPADs) allowed for the successful detection of Cr3+ and Cl-. The method achieved high selectivity in Cr3+ detection and utilized a distance-based pattern for Cr determination, resulting in accurate results compared to traditional titration methods at a 95% confidence level when applied to CF analysis in instant noodle seasonings.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Multidisciplinary
Eka Noviana, Tugba Ozer, Cody S. Carrell, Jeremy S. Link, Catherine McMahon, Ilhoon Jang, Charles S. Henry
Summary: Microfluidic paper-based analytical devices (muPADs) have gained significant interest as a promising analytical platform in the past decade, offering unique advantages over traditional microfluidics. This comprehensive Review highlights fabrication methods, device designs, and detection strategies, as well as the growing applications of muPADs, while discussing the field's need for further advancement to realize its full potential.
Article
Chemistry, Analytical
Ahmed A. Shalaby, Chia-Wen Tsao, Akihiko Ishida, Masatoshi Maeki, Manabu Tokeshi
Summary: Cancer is a leading cause of death worldwide, and early diagnosis is crucial for successful treatment. In developing countries, there is a need for low-cost, accurate, and easy to use point-of-need (PON) devices for cancer diagnosis and treatment follow-up. Paper-based analytical devices (PADs) are considered a key solution as they provide a low-cost platform for developing PON biosensors. This review discusses the various factors involved in the development of PADs for cancer biomarker detection and summarizes the advantages and disadvantages of each method.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Jaruwan Mettakoonpitak, Nalatthaporn Sawatdichai, Duangduean Thepnuan, Atitaya Siripinyanond, Charles S. Henry, Somporn Chantara
Summary: In this study, a dual-detection system of microfluidic paper-based analytical devices (muPADs) was proposed for simultaneous detection of reactive oxygen species (ROS) and copper (Cu) in aerosolized particulate matter (PM). The proposed muPADs showed good performance in detecting these toxic components.
Article
Multidisciplinary Sciences
Tianyi Huang, Simone B. Moos, Edward A. Boyle
Summary: Research findings in the eastern tropical North Pacific (ETNP) oxygen-deficient zone (ODZ) support theoretical and experimental studies predicting that lighter chromium is preferentially reduced in low-oxygen environments and residual dissolved chromium becomes heavier due to removal of particl-reactive Cr(III) on sinking particles. Microbial activity, dependent on sinking organic matter flux, may be the dominant mechanism for chromium transformation, rather than a simple inorganic chemical conversion.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Analytical
Raquel Catalan-Carrio, Tugce Akyazi, Lourdes Basabe-Desmonts, Fernando Benito-Lopez
Summary: The main challenge for the expansion and mass production of microfluidic paper-based analytical devices lies in the lack of fluid flow control due to uncontrolled fabrication protocols. The key to addressing this issue is to generate uniform and reliable microfluidic channels and optimize the fabrication process. Wax printing is the most common method, which requires analysis and optimization of parameters such as device shape, wax barrier width, and internal area.
Article
Chemistry, Analytical
Lorena Placer, Isela Lavilla, Francisco Pena-Pereira, Carlos Bendicho
Summary: This study presents the development of a 3D origami microfluidic paper-based analytical device (3D mu PAD) for the determination of iodide and iodate in edible seaweeds by colorimetric detection using a smartphone. The addition of a methacrylate holder improved the interlayer contact in 3D mu PADs, resulting in enhanced sensitivity and precision, as well as real-time monitoring. The assay relies on the formation of a blue triiodide-starch complex at the detection areas of the 3D mu PAD, providing an affordable, fast, and environmentally friendly method for simultaneous determination of inorganic iodine species. Under optimal conditions, the method achieved low limits of detection and quantification for iodide and iodate.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Chemistry, Analytical
Yingying Yuan, Bo Liu, Tianlu Wang, Na Li, Zhengyao Zhang, Hangyu Zhang
Summary: Cancer has become a crucial factor endangering human beings, and early screening of tumor markers is vital for improving cancer treatment and patients' quality of life. Microfluidic paper-based analytical devices (mu PADs) with integrated electrochemical detection methods offer advantages such as small size, portability, biodegradability, fast analysis, high sensitivity, and low cost, making them alternatives to conventional analytical instruments. This review discusses the fabrication process of mu PADs, focusing on the methods for creating paper-based hydrophobic barriers, as well as recent reports on mu PADs using electrochemical detection methods for common tumor marker detection. The limitations of current electrochemical mu PADs are also addressed.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Analytical
Bhavadharini Selvakumar, Arunkumar Kathiravan
Summary: This review summarizes the colorimetric and fluorimetric probes used in microfluidic paper-based analytical devices, discussing the relationship between structure and function, as well as their performance in sensing applications. It aims to help readers better understand the sensing mechanisms of various probes and promote their advancement in the field.
Review
Chemistry, Analytical
Nantana Nuchtavorn, Tomas Rypar, Lukas Nejdl, Marketa Vaculovicova, Mirek Macka
Summary: Distance-based detection (DbD) is widely used in analytical flow devices, with various formats and platforms. Its simplicity and ability for quantitative readout without auxiliary instrumentation make it highly attractive.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Abdellah Muhammed, Ahmed Hussen, Mesfin Redi, Takashi Kaneta
Summary: The study utilized microfluidic paper-based analytical devices (mu-PADs) fabricated in Japan to determine total chromium (Cr) in water, soil, and lettuce samples irrigated with wastewater in Ethiopia. Results showed that total Cr concentrations in all soil and lettuce samples exceeded permissible limits, with soil contamination level ranging from moderate to heavy based on the geo-accumulation index. The research successfully demonstrated the potential of using mu-PADs for remote pollution investigations in less-equipped laboratories by transporting them from a different facility.
ANALYTICAL SCIENCES
(2021)
Article
Chemistry, Analytical
Mason E. Bonacci, M. Ines G. S. Almeida, Yanlin Zhang, Spas D. Kolev
Summary: This study developed a novel microfluidic paper-based analytical device (μPAD) for the speciation of inorganic arsenic in environmental aqueous samples. The device showed advantages of simplicity, high sensitivity, and low detection limit.
Review
Chemistry, Analytical
Hardik Ramesh Singhal, Anusha Prabhu, M. S. Giri Nandagopal, Thangaraju Dheivasigamani, Naresh Kumar Mani
Summary: Paper-based devices for analytical applications have attracted researchers' interest due to their portability, versatility, and ease of interpretation, despite the barrier posed by sophisticated manufacturing techniques for widespread adoption in low-cost settings. Recent efforts have been made towards developing cost-effective paper-based analytical devices, with emphasis on utilizing readily available stationaries for fabrication. Additionally, the use of various low-cost or off-the-shelf equipment for creating hydrophobic barriers, electrodes, and housing for old detection techniques on plain paper has been explored in this review.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Ayushi Chauhan, Bhushan J. Toley
Summary: The barrier-free mu PAD device has been developed to detect multiple analytes without the need for wax patterning, improving the limit of colorimetric detection and streamlining large-scale manufacturing.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Somayeh Yousefi, Somayeh Makarem, Waleed Alahmad, Farzaneh Dorabadi Zare, Hadi Tabani
Summary: The study investigated the effects of three types of complexing agents on the extraction efficiency of zinc ions, with crown ethers, especially 18C6, showing the highest extraction efficiency. Moreover, the presence of complexing agents (excluding EDTA) reduced electroendosmosis flow. Under optimal conditions, the limit of detection and quantification were 5.0 μg L-1 and 15.0 μg L-1, with an extraction recovery rate of 92.5%.
Article
Chemistry, Analytical
Anna Prukjareonchook, Waleed Alahmad, Chadin Kulsing, Thanyalak Chaisuwan, Luxsana Dubas
Summary: For the first time, a highly permeable nanoporous carbon derived from melamine-based polybenzoxazine was applied as a solid-phase extraction sorbent for the trace analysis of atrazine herbicide in environmental water samples. The optimized extraction conditions showed good linearity in the concentration range of 5.00 to 30.0 µg/L, with low limits of detection and quantification. The reusable nature of the sorbent material was also demonstrated, making it a cost-effective option for herbicide enrichment. The developed method was successfully applied to analyze atrazine in various water samples, showing promising potential for efficient adsorption of herbicides.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ali Reza Fakhari, Seyedeh Mahsa Safavi, Ardeshir D. Yeganeh, Mostafa M. Amini, Ali Sahragard
Summary: The study utilized amine functionalized mesostructured cellular foam as a new support for electromembrane extraction, combined with corona discharge ion mobility spectrometer analysis, to simultaneously extract and quantify tramadol and methadone from human urine samples. The method had high recoveries, sensitivity, and proved to be applicable for determining model drugs in urine samples.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Applied
Ali Sahragard, Waleed Alahmad, Pakorn Varanusupakul
Summary: This study developed an electrocolorimetric extraction technique for the simultaneous preconcentration and determination of Ni(II) in chocolate samples. The method showed a good linear range, low detection limit, and good stability and precision.
Article
Chemistry, Multidisciplinary
Ali Sahragard, Ali Reza Fakhari, Kobra Sadat Hasheminasab, Zolfaghar Aladaghlo
Summary: In this study, a carbon nanotubes assisted electromembrane extraction method (CNTs/EME) coupled with capillary electrophoresis (CE) was developed for the preconcentration and determination of cocaine in various real samples. The CNTs/EME method provided higher extraction efficiencies at a lower extraction voltage compared to the EME method. The optimized conditions achieved a wide linear range of 7-3000 ng mL(-1), a low detection limit of 2.12 ng mL(-1), and high preconcentration factor, extraction recovery, and repeatability. The method was successfully applied to determine cocaine in wastewater and biological samples.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2023)
Review
Chemistry, Analytical
Ali Sahragard, Pakorn Varanusupakul, Manuel Miro
Summary: LPME-ECD technology is a fast and portable method for analyzing various analytes in different samples. This review critically evaluates the LPME-ECD technology from 2010 to 2022 and provides future development prospects.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Fatima Alabdo, Waleed Alahmad, Untika Pengsomjit, Mohammad Halabi, Pakorn Varanusupakul, Charoenkwan Kraiya
Summary: This paper introduces a simple, environmentally friendly, and cost-effective method for the mass production of graphene sheets. By electrochemically exfoliating pencil graphite and optimizing various parameters, the optimal conditions for synthesis were determined. Various characterization techniques were used to analyze the synthesized graphene, which exhibited good conductivity and adsorption capacity. This method has great potential for applications, especially in low-income countries for large-scale production and commercialization.
Article
Chemistry, Applied
Zolfaghar Aladaghlo, Siamak Javanbakht, Ali Sahragard, Ali Reza Fakhari, Ahmad Shaabani
Summary: An ultrasound-assisted dispersive solid phase microextraction (UA-DSPME) approach was developed for trace level analysis of triazole fungicides in real samples. By using a newly prepared nanosorbent and optimizing extraction parameters, this method achieved good analysis performance.
Article
Chemistry, Analytical
Anna Prukjareonchook, Waleed Alahmad, Charoenkwan Kraiya, Chadin Kulsing, Thanyalak Chaisuwan, Luxsana Dubas
Summary: A selective and sensitive method for trace analysis of atrazine in surface water samples was developed using semi-automated solid-phase extraction coupled with a colorimetric method. The method utilized a new coupling agent, p-anisidine, to form a red-colored dye product. The method showed good linearity and low detection and quantification limits, and was validated through spiked samples analysis.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Applied
Thidarat Samkumpim, Waleed Alahmad, Hadi Tabani, Pakorn Varanusupakul, Charoenkwan Kraiya
Summary: The generation of oxygen in gel electromembrane extraction (G-EME) introduces a negative error in the analysis of easily oxidized species like nitrite, as it oxidizes nitrite to nitrate. To minimize this oxidation effect and enable simultaneous analysis, oxygen scavengers were applied to the acceptor phase of the G-EME system. Among several tested scavengers, a mixture of sulfite and bisulfite (14 mg L-1) showed the highest efficiency in preventing nitrite oxidation. The optimized method allowed for the simultaneous determination of nitrite and nitrate in sausage samples.
Article
Chemistry, Multidisciplinary
Waleed Alahmad, Somsak Pianwanit, Luxsana Dubas, Charoenkwan Kraiya
Summary: The educators at the Department of Chemistry, Chulalongkorn University in Thailand developed an online chemistry experiment called Lab@Home, which allowed remote student participation through prerecorded videos and online guidance via the Zoom app. Lab@Home utilized simple materials and clear plastic sheet protectors for experiments, making it easy to distribute and enhancing safety. This experiment has been successfully implemented and taught for two semesters with 300 students completing the self-paced laboratory course, serving as an option for programs exploring novel off-campus approaches to laboratory experiences.
JOURNAL OF CHEMICAL EDUCATION
(2023)
Article
Chemistry, Analytical
Waleed Alahmad, Ahmet Cetinkaya, S. Irem Kaya, Pakorn Varanusupakul, Sibel A. Ozkan
Summary: Studied the electrochemical behavior of ceftriaxone on a glassy carbon electrode and developed a sensor based on molecularly imprinted polymer for selective and sensitive detection of antibiotic drugs in food safety and environmental protection.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Ali Sahragard, Pakorn Varanusupakul, Manuel Miro
Summary: This review critically examines the current state-of-the-art of nanomaterial-based electrochemical sensors in flow injection (NBES-FI) platforms for in-line determination of environmental pollutants from 2013 to mid-2023. The synergistic effects of FI platforms and nanomaterial-based modifiers, such as metal nanoparticles and carbon-based nanomaterials, are discussed in detail, focusing on minimizing electrode fouling, alleviating overpotential, and boosting overall figures of merit. The impact of experimental parameters, including electrode properties and design, synthesis routes of nanomaterials, and electrochemical detection techniques, on the analytical performance of NBES-FI is thoroughly evaluated. Current challenges and the need for real-world implementation of NBES-FI in environmental settings are outlined, along with perspectives on integrating NBES-FI with microextraction approaches and utilizing 3D printing technology for customized fluidic platforms.
TRENDS IN ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Analytical
Waleed Alahmad, Puttaruksa Varanusupakul, Pakorn Varanusupakul
Summary: Food safety is a major concern for global public health, and the development of analytical tools for rapid screening of food contaminants is highly important. Microfluidic paper-based analytical devices (mu PADs) have emerged as a rapid and low-cost screening tool and have been widely used in the field of food safety.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Michel Rocha Baqueta, Augusto Cesar Costa-Santos, Ana Paula Rebellato, Gisele Marcondes Luz, Juliana Azevedo Lima Pallone, Federico Marini, Alexsandro Lara Teixeira, Douglas N. Rutledge, Patricia Valderrama
Summary: This study reports the essential element composition of new Brazilian Canephora coffees and applies chemometric tools for analysis. The results demonstrate the suitability of this method for origin and species discrimination based on the inorganic fraction of coffee.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Mengjie Li, Jiapeng Wang, You Zhou, Yang Chen, Lingying Xia
Summary: A novel photoelectrochemical biosensor based on gold nanoparticles and specific structures was developed for highly sensitive detection of mercury ion. The multiple sandwich structures hindered electron supply and light harvesting, resulting in a weakened PEC signal, while the specific structures extinguished the PEC signal, enabling quantitative detection of Hg2+. The sensor exhibited high selectivity and stability, with potential applications in environmental detection, biological analysis, and medical research.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Mohamed A. Korany, Rasha M. Youssef, Marwa A. A. Ragab, Mostafa A. Afify
Summary: A stability-indicating fit-for-purpose method was developed for the determination of HC, TL, and PS in syrup dosage form. The method successfully separated CL from THY and quantified the analytes using HPLC-DAD. The robustness of the method was assessed through statistical analysis and self-validation.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Lingling Lin, Minyu Li, Ping Li, Chenqing Ye, Huanglong Zhuang, Shaohuang Weng, Feng Chen
Summary: This study developed a highly sensitive and selective electrochemical sensor for simultaneous detection of dopamine and uric acid. The sensor exhibited excellent anti-interference and stability, and could accurately measure dopamine and uric acid in human urine samples.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Peifang Chen, Caiyun Jiang, Zhouping Wang, Hong-zhen Lian, Xiaoyuan Ma
Summary: In this study, a high-performance SERS-active aptasensor was successfully developed for the quantitative analysis of AFB1 in cereal grains, which is of great significance in the field of food safety.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
E. Abas, C. Marina-Montes, C. Perez-Marin, J. Puimedon, J. Anzano
Summary: This study conducted a comprehensive measurement of natural and anthropogenic radionuclides in soil, water, and air in different locations around Deception Island in Antarctica. The results revealed significant levels of 210Pb and anthropogenic 137Cs in soil samples near old human settlements and facilities, as well as detectable levels of 137Cs and 60Co in water samples from old hunting areas. The findings also suggested potential resuspension processes based on higher-than-expected air quality results.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Joao Franciso Allochio, Nayara A. dos Santos, Nathalia dos S. Conceicao, Clara S. D. Baptista, Keyller B. Borges, Valdemar Lacerda Jr, Wanderson Roma
Summary: This study developed a fiber spray ionization mass spectrometry (FSI-MS) method, which shows great potential in detecting illicit drugs. Compared with paper spray ionization mass spectrometry (PSI-MS), FSI-MS demonstrates higher sensitivity in COC detection.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Dina A. Ahmed, Ola G. Hussein, Mamdouh R. Rezk, Mohamed Abdelkawy, Yasmin Rostom
Summary: The main goal of this study was to develop two green chromatographic techniques, HPLC and TLC, for the determination of alcaftadine (ALF) in pharmaceutical formulation and biological samples. The developed HPLC technique showed high efficiency and minimal environmental impact, successfully identifying ALF in the presence of its degradate. The TLC method provided a stability indicating study for ALF and was determined to be safe, green, and eco-friendly.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Abdullah Taner Bisgin
Summary: A green, speedy, and handy method for separation and determination of four commonly used food colorants was established using vortex assisted sequential-simultaneous liquid phase micro-extraction (VA-SS-LPME). The method does not require any instrumental chromatographic techniques. The procedure includes sequential separation steps using different extractants and simultaneous UV-vis spectrophotometric determination steps. The method is environmentally friendly and applicable for determination of colorants in food and pharmaceuticals.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Yifan Zhang, Tong Zhang, Wenjing Ba, Li Liu, Yuan Rao, Xiaodan Zhang, Hanhan Zhang, Xiu Jin
Summary: This paper proposes a novel spectral transfer modelling method based on neural network architecture searching for the asymptomatic prediction of Akizuki pear cork spot disorder. The experiments show that the model by this method is more effective, achieving an accuracy of 82.61%.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Krzysztof Greda, Maja Welna, Anna Szymczycha-Madeja, Pawel Pohl
Summary: For the first time, a dispersive micro-solid phase extraction (D-mu SPE) based on graphene oxide was used for the ultrasensitive determination of Cd. With this method, Cd can be efficiently extracted from a mixture of alkali and alkaline earth metals without the need for an elution step. The combination of D-mu SPE and SAGD OES significantly reduces matrix effects and improves the tolerance of Cd to alkali metals. The method shows simplicity in the measurement system and the commercially available nanosorbent used.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
P. K. Fathima Anjila, G. R. Tharani, Anand Sundaramoorthy, Venkat Kumar Shanmugam, Karthikeyan Subramani, Shanmugavel Chinnathambi, Ganesh N. Pandian, Vimala Raghavan, Andrews Nirmala Grace, Singaravelu Ganesan, Mangaiyarkarasi Rajendiran
Summary: This work proposes a rapid and sensitive spectroscopic method for detecting melamine in food products using rare-earth Terbium-doped Graphene Quantum Dots (Tb-GQDs) synthesized by microwave and simple chemical conjugation methods. The synthesized Tb-GQDs show a spherical shape with a size of approximately 6 nm and a quantum yield of 52%. The maximum detection limit for melamine concentration in milk and milk products is found to be 0.31 μM. The dual emitting Tb-GQDs provide a sensitive and effective platform for real-time detection of melamine in food samples, particularly in milk, and show promising potential in the food industry.
MICROCHEMICAL JOURNAL
(2024)
Review
Chemistry, Analytical
Piyush Dey, Mandeep Kaur, Akhil Khajuria, Dilmeet Kaur, Manpreet Singh, Hema Kumari Alajangi, Neha Singla, Gurpal Singh, Ravi Pratap Barnwal
Summary: Environmental issues, such as the uncontrolled release of dangerous pollutants, have significant impacts on human health. Traditional methods for detecting pollutants require specialized personnel and equipment, but nanotechnology has improved the performance of biosensors. This article discusses the use of nanotechnology in pollutant detection and the associated techniques.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Sa Dong, Qiuyun Shi, Lingjun Guan, Yulong Wang, Pengyan Liu, Cunzheng Zhang, Jianguo Feng
Summary: In this study, a highly sensitive indirect competitive chemiluminescence enzyme immunoassay (icCLEIA) method was developed for the determination of sodium pentachlorophenolate (PCP-Na) and its metabolite pentachlorophenol (PCP). The method showed high specificity and affinity with a detection limit of 0.0032 ng/mL for PCP-Na and 0.0192 ng/mL for PCP. The method had no cross reaction with other chlorophenols compounds except for PCP. The average recoveries in chicken, pork and fish samples were 81.3-105.8% with low coefficient of variation (CV).
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Palaniappan Ilayaraja, Murugan Manivannan, Paramasivam Parthiban
Summary: Nirmatrelvir, an antiviral drug used for the treatment of COVID-19, has been recommended by the World Health Organization. We developed an optimized analytical method for the quantification of Nirmatrelvir and its products, with high sensitivity and a wide linear range. The method also meets the requirements for greenness evaluation.
MICROCHEMICAL JOURNAL
(2024)
