Multi-attribute Raman spectroscopy (MARS) for monitoring product quality attributes in formulated monoclonal antibody therapeutics

Raman Spectroscopy to Monitor Post-Translational Modifications and Degradation in Monoclonal Antibody Therapeutics

(2020) Bethan S. McAvan et al.   ANALYTICAL CHEMISTRY

The Pharmaceutical Industry in 2018. An Analysis of FDA Drug Approvals from the Perspective of Molecules

(2019) Beatriz G. de la Torre et al.   MOLECULES

Rapid, quantitative determination of aggregation and particle formation for antibody drug conjugate therapeutics with label-free Raman spectroscopy

(2019) Chi Zhang et al.   ANALYTICA CHIMICA ACTA

Solid-State Quantification of Cocrystals in Pharmaceutical Tablets Using Transmission Low-Frequency Raman Spectroscopy

(2019) Motoki Inoue et al.   ANALYTICAL CHEMISTRY

Detection and Identification of the Vibrational Markers for the Quantification of Methionine Oxidation in Therapeutic Proteins

(2018) Gurusamy Balakrishnan et al.   ANALYTICAL CHEMISTRY

Real-time monitoring of antibody glycosylation site occupancy by in situ Raman spectroscopy during bioreactor CHO cell cultures

(2018) Meng-Yao Li et al.   BIOTECHNOLOGY PROGRESS

Optimization of classification and regression analysis of four monoclonal antibodies from Raman spectra using collaborative machine learning approach

(2018) Laetitia Minh Maï Le et al.   TALANTA

The Increasingly Human and Profitable Monoclonal Antibody Market

(2018) António L. Grilo et al.   TRENDS IN BIOTECHNOLOGY

Sample-Size Planning for Multivariate Data: A Raman-Spectroscopy-Based Example

(2018) Nairveen Ali et al.   ANALYTICAL CHEMISTRY

Mitigation of Oxidation in Therapeutic Antibody Formulations: a Biochemical Efficacy and Safety Evaluation of N-Acetyl-Tryptophan and L-Methionine

(2018) Michelle Z. Dion et al.   PHARMACEUTICAL RESEARCH

On-line prediction of the glucose concentration of CHO cell cultivations by NIR and Raman spectroscopy: Comparative scalability test with a shake flask model system

(2017) Bence Kozma et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Dispersive Raman Spectroscopy for Quantifying Amorphous Drug Content in Intact Tablets

(2017) Busolo Wa Wabuyele et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Comprehensive Study of a Handheld Raman Spectrometer for the Analysis of Counterfeits of Solid-Dosage Form Medicines

(2017) Klara Dégardin et al.   Journal of Spectroscopy

Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing

(2016) Karen A. Esmonde-White et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Rapid Identification of Biotherapeutics with Label-Free Raman Spectroscopy

(2016) Santosh Kumar Paidi et al.   ANALYTICAL CHEMISTRY

In-line and real-time prediction of recombinant antibody titer by in situ Raman spectroscopy

(2015) Silvère André et al.   ANALYTICA CHIMICA ACTA

Concomitant Raman spectroscopy and dynamic light scattering for characterization of therapeutic proteins at high concentrations

(2015) Chen Zhou et al.   ANALYTICAL BIOCHEMISTRY

Deep-Ultraviolet Resonance Raman (DUVRR) Spectroscopy of Therapeutic Monoclonal Antibodies Subjected to Thermal Stress

(2015) Justin Bueno et al.   ANALYTICAL CHEMISTRY

Review of Fluorescence Suppression Techniques in Raman Spectroscopy

(2015) Dong Wei et al.   APPLIED SPECTROSCOPY REVIEWS

The molecular interaction of a protein in highly concentrated solution investigated by Raman spectroscopy

(2015) Chikashi Ota et al.   BIOPOLYMERS

Structural Changes and Aggregation Mechanisms for Anti-Streptavidin IgG1 at Elevated Concentration

(2015) Gregory V. Barnett et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Development of a quantitative mass spectrometry multi-attribute method for characterization, quality control testing and disposition of biologics

(2015) Richard S Rogers et al.   mAbs

Assessment of the Protein–Protein Interactions in a Highly Concentrated Antibody Solution by Using Raman Spectroscopy

(2015) Chikashi Ota et al.   PHARMACEUTICAL RESEARCH

Identification of Subvisible Particles in Biopharmaceutical Formulations Using Raman Spectroscopy Provides Insight into Polysorbate 20 Degradation Pathway

(2015) Miguel Saggu et al.   PHARMACEUTICAL RESEARCH

Monitoring Antibody Aggregation in Early Drug Development Using Raman Spectroscopy and Perturbation-Correlation Moving Windows

(2014) Ramón Gómez de la Cuesta et al.   ANALYTICAL CHEMISTRY

The challenge of applying Raman spectroscopy to monitor recombinant antibody production

(2013) Lorna Ashton et al.   ANALYST

Buffer capacity of biologics-from buffer salts to buffering by antibodies

(2013) Anne R. Karow et al.   BIOTECHNOLOGY PROGRESS

The need for innovation in biomanufacturing

(2012) Uwe Gottschalk et al.   NATURE BIOTECHNOLOGY

Detection and chemical profiling of medicine counterfeits by Raman spectroscopy and chemometrics

(2011) Klara Dégardin et al.   ANALYTICA CHIMICA ACTA

Identification of Potential Sites for Tryptophan Oxidation in Recombinant Antibodies Using tert-Butylhydroperoxide and Quantitative LC-MS

(2011) Miriam Hensel et al.   PLoS One

Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe

(2010) Nicholas R. Abu-Absi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Rapid characterization and quality control of complex cell culture media solutions using raman spectroscopy and chemometrics

(2010) Boyan Li et al.   BIOTECHNOLOGY AND BIOENGINEERING

Application of Vibrational Spectroscopy to the Structural Characterization of Monoclonal Antibody and its Aggregate

(2009) Cynthia Li et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY