Article
Health Care Sciences & Services
Anastasiia S. Boiko, Irina A. Mednova, Elena G. Kornetova, Anastasiia A. Goncharova, Arkadiy Semke, Nikolay A. Bokhan, Svetlana A. Ivanova
Summary: Metabolic syndrome (MetS) is a common complication of schizophrenia that is exacerbated by long-term use of antipsychotics. The study found that levels of leptin were significantly increased in MetS patients, while ghrelin levels were significantly decreased. There were fewer significant correlations between ghrelin and other hormones in MetS patients compared to those without MetS.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Food Science & Technology
Maria Helena Araujo de Vasconcelos, Renata Leite Tavares, Emanuel Ubaldino Torres Junior, Victor Augusto Mathias Dorand, Kamila Sabino Batista, Lydiane Tavares Toscano, Alexandre Sergio Silva, Angela Maria Tribuzy de Magalhaes Cordeiro, Bruno Ranieri Lins de Albuquerque Meireles, Rubens da Silva Araujo, Adriano Francisco Alves, Jailane de Souza Aquino
Summary: This study investigated the anti-adiposity effect of extra virgin coconut oil (E-VCO) on obese rats and found that E-VCO reduced body mass and adiposity index, improved hormonal parameters, and decreased liver fat accumulation. E-VCO also had positive effects on metabolic parameters.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Endocrinology & Metabolism
Olivia R. Ghosh-Swaby, Amy C. Reichelt, Paul A. S. Sheppard, Jeffrey Davies, Timothy J. Bussey, Lisa M. Saksida
Summary: This article discusses the role of metabolic hormones in neural plasticity and cognition, as well as the relationship between metabolic hormones and metabolic syndromes such as obesity and diabetes. Adjusting metabolic hormone levels can restore metabolic homeostasis and enhance cognitive function.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Review
Food Science & Technology
Varenka Barbero-Becerra, Eva Juarez-Hernandez, Norberto C. Chavez-Tapia, Misael Uribe
Summary: Inulin, a prebiotic, has the potential to lower lipid levels and regulate glucose metabolism, potentially serving as a therapeutic option for diseases related to metabolic syndrome. Evidence suggests inulin has beneficial effects on dysbiosis and hepatic lipogenesis, however, further studies are necessary to confirm its therapeutic role in treating MAFLD.
FOOD REVIEWS INTERNATIONAL
(2022)
Article
Neurosciences
Jennifer M. Erichsen, Jim R. Fadel, Lawrence P. Reagan
Summary: Insulin and leptin are important in metabolism and have multiple functions in both the periphery and central nervous system. Resistance to insulin and leptin can impact cognition and neuropsychiatric diseases, with deficits in neuroplasticity potentially reversible by restoring sensitivity to these hormones.
Review
Biochemistry & Molecular Biology
Vania Miloucheva Peneva, Dora Dimitrova Terzieva, Mitko Dimitrov Mitkov
Summary: Metabolic syndrome (MetS) is a combination of cardiometabolic risk factors that increase the chances of developing type 2 diabetes, cardiovascular diseases, and death. In women, an insulin-resistant state associated with polycystic ovarian syndrome and increased intra-abdominal fat deposition promotes the development of MetS and increases cardiovascular risk. The hormone melatonin, which is regulated by the suprachiasmatic nucleus, plays a role in this process. The relationship between melatonin and the main features of MetS in women, including glucose metabolism, lipid disturbances, hypertension, and vascular dysfunction, is discussed in this review.
Article
Cell Biology
Shangang Zhao, Qian Lin, Wei Xiong, Li Li, Leon Straub, Dinghong Zhang, Rizaldy Zapata, Qingzhang Zhu, Xue-Nan Sun, Zhuzhen Zhang, Jan-Bernd Funcke, Chao Li, Shiuhwei Chen, Yi Zhu, Nisi Jiang, Guannan Li, Ziying Xu, Steven C. Wyler, May-Yun Wang, Juli Bai, Xianlin Han, Christine M. Kusminski, Ningyan Zhang, Zhiqiang An, Joel K. Elmquist, Olivia Osborn, Chen Liu, Philipp E. Scherer
Summary: Antipsychotic drugs can cause weight gain and diabetes, and hyperleptinemia plays a key role. Suppression of leptin rise can reduce the adverse effects of these drugs.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Kaiser Wani, Malak N. K. Khattak, Gamal M. Saadawy, Omar S. Al-Attas, Majed S. Alokail, Nasser M. Al-Daghri
Summary: The study aimed to assess the validity of the Single Point Insulin Sensitivity Estimator (SPISE) in predicting Metabolic Syndrome (MetS) in Arab adolescents. A cross-sectional study was conducted on 951 Saudi adolescents aged 10-17 years. The results showed that the SPISE index was significantly lower in MetS patients and correlated with resistin, leptin, C-reactive protein, adiponectin, and 25(OH) D. The study suggests that the SPISE index is a simple and promising diagnostic marker for insulin sensitivity and MetS in Arab adolescents.
Review
Endocrinology & Metabolism
Sean DeLacey, Jami L. Josefson
Summary: The increasing rates of childhood obesity have a significant impact on future health outcomes. However, there is a lack of consensus on the best anthropometric measure to predict insulin resistance in children.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Santiago Guerra-Cantera, Laura M. Frago, Roberto Collado-Perez, Sandra Canelles, Purificacion Ros, Alejandra Freire-Regatillo, Maria Jimenez-Hernaiz, Vicente Barrios, Jesus Argente, Julie A. Chowen
Summary: Dietary intervention can impact metabolic hormones and glucose tolerance in male and female mice, with some parameters returning to normal levels after switching back to a standard diet, but with differences in the rate of recovery. Sex differences were also observed in the response to high fat diet and the switch to a normal diet, particularly in circulating levels of IGF2 and IGFBP2.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Daniela Diaz-Catalan, Gema Alcarraz-Vizan, Carlos Castano, Sara de Pablo, Julia Rodriguez-Comas, Antonio Fernandez-Perez, Mario Vallejo, Sara Ramirez, Marc Claret, Marcelina Parrizas, Anna Novials, Joan -Marc Servitja
Summary: The study found that inhibition of BACE2 in a model of diet-induced obesity leads to exacerbated body weight gain, hyperinsulinemia, and insulin resistance. This suggests that inhibition of BACE2 may worsen the adverse metabolic effects associated with obesity.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Michalina Lubawy, Anna Blacha, Marcin Nowicki, Tomasz Deja, Krzysztof Walkowski, Dorota Formanowicz
Summary: This study evaluated the levels of selected appetite hormones (ghrelin, leptin) and inflammatory parameters (TNF-alpha and IL-6) in patients with urolithiasis, metabolic syndrome, and hyperuricemia. The results showed differences in the levels of these hormones and inflammatory markers among the studied groups. Furthermore, correlations were found between appetite hormones, inflammatory markers, and uric acid levels in urolithiasis patients.
Article
Endocrinology & Metabolism
Lars Lind, Samira Salihovic, Johan Sundstrom, Solve Elmstahl, Ulf Hammar, Koen Dekkers, Johan Arnlov, J. Gustav Smith, Gunnar Engstrom, Tove Fall
Summary: This study compared the plasma metabolome in obese subjects with and without metabolic syndrome (MetS) to normal-weight subjects without MetS. The results showed significant differences in metabolite profiles between obese and normal-weight individuals without MetS, with a gradual deterioration in metabolite profile from lean to obese to MetS. The pathways highlighted in this study, such as amino acid synthesis/metabolism and sphingolipid metabolism, may play a role in this metabolic deterioration, with insulin resistance as a potential mediator.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Andrei Catalin Oprescu, Cristina Grosu, Walther Bild
Summary: This study aimed to investigate the association between the severity of metabolic imbalances, insulin resistance, leptin concentration, and the presence of cognitive disorders. It also assessed the possible protective role of certain drugs used in the treatment of type 2 diabetes mellitus and dyslipidemia. The study found that cognitive assessment results were associated with anthropometric parameters, glycemic control parameters, and leptin levels. Further research is needed to establish the relationship between metabolic syndrome components and cognitive decline in diabetic patients.
Article
Medicine, Research & Experimental
Temitope Gabriel Adedeji, Emiola Oluwabunmi Olapade-Olaopa
Article
Nutrition & Dietetics
Temitope Gabriel Adedeji, Adesoji Fasanmade, Emiola Olapade-Olaopa
Article
Medicine, Research & Experimental
Temitope Gabriel Adedeji, Adesoji A. Fasanmade, Emiola Oluwabunmi Olapade-Olaopa
Article
Nutrition & Dietetics
Temitope Gabriel Adedeji, Emiola Oluwabunmi Olapade-Olaopa
Summary: The study aimed to investigate the effects of diet reversal on the structure and function of normal and obstructed bladders. Results showed that reversing the diet to standard chow could reverse all diet-induced changes, particularly those related to inflammation and fibrosis in obstructed bladders.
Article
Multidisciplinary Sciences
Abodunrin Adebayo Ojetola, Temitope Gabriel Adedeji, Adesoji Adedipe Fasanmade
Summary: This study investigated the cardiovascular effects of DRLC in normal Wistar rats, finding that DRLC 250 significantly increased total thiol, GSH, and GPx levels in heart tissues, while decreasing GGT, atherogenic index, and CRP levels. This suggests that DRLC supplementation may help sustain heart function and reduce atherogenicity in normal Wistar rats.
Article
Chemistry, Medicinal
Olubayode Bamidele, Nkiruka Chisom Okeke, Temitope Gabriel Adedeji, Lawrence Dayo Adedayo, Akinjide Moses Akinnuga
CHINESE HERBAL MEDICINES
(2020)
Review
Urology & Nephrology
T. G. Adedeji, A. A. Fasanmade, E. O. Olapade-Olaopa
AFRICAN JOURNAL OF UROLOGY
(2016)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.