Review
Multidisciplinary Sciences
Mohammad Hassan Hodroj, Ali Taher
Summary: Thalassemia management has advanced with iron chelation therapy, leading to increased life expectancy. However, this has also resulted in the emergence of new morbidities, including cancer. While there is still uncertainty about the mechanisms and risks of cancer development in thalassemia patients, multiple cases have been reported in the literature.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Medicine, General & Internal
Won Jung Choi, Yu Ah Hong, Ji Won Min, Eun Sil Koh, Hyung Duk Kim, Tae Hyun Ban, Young Soo Kim, Yong Kyun Kim, Seok Joon Shin, Seok Young Kim, Chul Woo Yang, Yoon-Kyung Chang
Summary: The study found that HTG is a significant risk factor for glomerulosclerosis in IgAN patients, showing a clear correlation with renal histopathological features, which is of great clinical significance.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medical Laboratory Technology
Lily Olayinka, Izmarie Poventud-Fuentes, Shajia Rahman Ansari, Emily Garnett, Sridevi Devaraj
Summary: PEG-asparaginase-induced hypertriglyceridemia is rare in the treatment of lymphoblastic lymphoma in children. This case highlights the potential of PEG-asparaginase and Olazanpine to induce hypertriglyceridemia in acute lymphoblastic leukemia, emphasizing the importance of obtaining baseline triglyceride measurements for these patients.
CLINICA CHIMICA ACTA
(2022)
Article
Multidisciplinary Sciences
Wittaya Jomoui, Sitthichai Panyasai, Pornpun Sripornsawan, Wanicha Tepakhan
Summary: This study characterized α-thalassemia mutations among Hb H disease patients in Thailand and developed a new PCR method for diagnosis. The findings suggest that the common mutation --(SEA) should be included in routine genetic counseling and diagnosis in this region.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Qing Liu, Zhihong Zhu, Wen Cai, Liu Yang, ShuangDi Li, Jiarong Zhang
Summary: This study aimed to evaluate the potential of triglyceride (TG) concentrations at the time of oral lipid tolerance test (OLTT) measurement in the second trimester to predict preeclampsia and elucidate the lipid metabolic changes related to these diseases. The study found that pregnant women who subsequently developed preeclampsia had higher concentrations of 4-hour postprandial TG than those who remained normotensive. In linear logistic regression analyses, mid-trimester 4-hour postprandial TG concentrations at the time of OLTT measurement were significantly higher in preeclamptic cases than in controls.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Optics
Nan Wan, Zhe Li, Myeongsu Seong, Ke Zhang, Wei Niu, Rong Wu, Sung-Liang Chen
Summary: The level of triglyceride (TG) in blood is crucial to human health. A higher level of TG can lead to cardiovascular disease and acute pancreatitis. In this study, photoacoustic (PA) microscopy is used to test the PA amplitude of blood solutions with different TG concentrations. The PA amplitude increases with increasing TG concentration in blood solutions, which presents an opportunity for noninvasively diagnosing hypertriglyceridemia using photoacoustics.
Review
Nutrition & Dietetics
Maria Elena Capra, Giacomo Biasucci, Giuseppe Banderali, Cristina Pederiva
Summary: Hypertriglyceridemia is a lipid disorder that can range in prevalence, being very common when considering slightly elevated triglyceride plasma values and extremely rare when only severely elevated levels are considered. The severe forms are often caused by genetic mutations, while secondary forms are usually less severe and can be linked to various diseases or drugs. Nutritional intervention plays a crucial role in treating hypertriglyceridemia, with different approaches for different forms.
Article
Environmental Sciences
Duanbin Li, Zhezhe Chen, Yu Shan, Tianli Hu, Xulin Hong, Jun Zhu, Yunhui Zhu, Guosheng Fu, Min Wang, Wenbin Zhang
Summary: This study found a positive association between aldehyde co-exposure and hypertriglyceridemia (HTG), which may be partially mediated by liver enzymes. Aldehydes such as 4AL, 5AL, I5AL, and 7AL were shown to have the strongest impact on HTG. Additionally, aldehyde co-exposure was also positively associated with liver enzymes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Biochemistry & Molecular Biology
Yoichi Miura, Hidenori Suzuki
Summary: Both fasting and non-fasting hypertriglyceridemia are risk factors for atherosclerotic disease, but it is uncertain whether they increase the risks of carotid artery stenosis progression. Statins can prevent carotid plaque progression and improve plaque stability. However, there is currently no evidence that combining non-statin lipid-lowering drugs with statins provides additional benefits in preventing cerebrovascular events and stenosis progression in patients with carotid artery stenosis. This article explores the relationship between hypertriglyceridemia and carotid artery stenosis, as well as the potential role of lipid-lowering drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Talha M. Qureshi, Anam Khan, Huma Javaid, Abdalaziz Tabash, Mohammed S. Hussein, Mohamed O. Othman
Summary: The study aimed to identify the prevalence of risk factors for secondary hypertriglyceridemia in patients presenting with HIAP. Results showed that the majority of patients with HIAP had secondary causes for HTG, emphasizing the importance of identifying secondary causes of HTG during acute hospitalization.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Review
Pediatrics
Syahirah Amnani Suhaimi, Ihsan Nazurah Zulkipli, Hazim Ghani, Mas Rina Wati Abdul-Hamid
Summary: This review discusses the applications of next-generation sequencing (NGS) technology in screening and diagnosing thalassemias, highlighting its advantages in terms of high throughput, accuracy, and adaptability, as well as its importance in detecting rare variants, solving complex problems, and providing alternative methods. However, there are still limitations that prevent it from completely replacing conventional methods.
FRONTIERS IN PEDIATRICS
(2022)
Article
Endocrinology & Metabolism
Arijit Singha, Pradip Mukhopadhyay, Sujoy Ghosh
Summary: This study evaluated the prevalence of adrenal insufficiency (AI) in patients with hemoglobin E/beta thalassemia and its association with disease severity and transfusion requirements. The results showed that AI is common in these patients and is independent of transfusion dependency and disease severity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Lin Chen, Xingxing Zhou, Xiamin Tu, Hongmei Cheng, Zhaotao Duan, Guotao Lu, Yuan Yuan
Summary: This study aims to explore the experiences and perceptions of home-based self-management among patients with recurrent hypertriglyceridemic acute pancreatitis (HTG-RAP). Through interviews, themes of sorrow, struggle, adaptation, and benefits were identified, highlighting the significance of these key points in improving patients' quality of life and lifestyle modification.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Shu Ye, Hui Ran, Hongmei Zhang, Hui Wu, Wen Li, Shichun Du, Qing Su
Summary: KPT2D is a subtype of T2D with characteristics of overweight or obesity, more severe hyperglycemia, and impaired beta-cell functions. Patients with KPT2D have significantly higher serum triglyceride levels, with a higher proportion of very high levels compared to T2D patients.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Review
Multidisciplinary Sciences
Jeanne Boudreaux
Summary: This article provides an overview of the current challenges and recommendations regarding transfusion management for thalassemia patients. It also discusses the components of blood safety and blood product modification for specific populations. The article describes adverse transfusion reactions and explores newer technologies to minimize the risk of transfusion-associated pathogens. Finally, the article briefly discusses research in blood storage and manufactured blood.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Critical Care Medicine
Jhuma Sankar, Javed Ismail, Rashmi Das, Nishanth Dev, Anubhuti Chitkara, M. Jeeva Sankar
JOURNAL OF INTENSIVE CARE MEDICINE
(2019)
Review
Pediatrics
Girish Chandra Bhatt, Priya Gogia, Martin Bitzan, Rashmi Ranjan Das
ARCHIVES OF DISEASE IN CHILDHOOD
(2019)
Review
Medicine, General & Internal
Rashmi Ranjan Das, Nishant Jaiswal, Nishanth Dev, Nikita Jaiswal, Sushree Samiksha Naik, Jhuma Sankar
FRONTIERS IN MEDICINE
(2020)
Article
Pediatrics
Sujit Kumar Tripathy, Shakti Swaroop, Sandeep Velagada, Debashree Priyadarshini, Rashmi Ranjan Das, Amit Kumar Satpathy, Kanhaiyalal Agrawal
FRONTIERS IN PEDIATRICS
(2020)
Article
Pediatrics
Nihar Ranjan Mishra, Amit Agrawal, Rashmi Ranjan Das
Summary: This meta-analysis compared the efficacy and safety of hypertonic saline and mannitol in reducing elevated intracranial pressure (ICP) in children. The results showed no significant difference in mortality rate between the two groups. However, serum osmolality was significantly higher in the mannitol group, while adverse events like shock and dehydration were higher in the mannitol group, and hypernatremia was higher in the hypertonic saline group.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Editorial Material
Pediatrics
Swathi Nakka, Rashmi Ranjan Das
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Immunology
Monalisa Mohanty, Baijayantimala Mishra, Amit Kumar Satapathy, Krishna Mohan Gulla, Rashmi Ranjan Das, Bhagirathi Dwibedi, Kavita Gupta, Prabhudutta Mamidi, Sailendra Panda
Summary: This study retrospectively analyzed clinical and laboratory data of children with acute respiratory infection (ARI) and found that human bocavirus (HBoV) may play a pathogenic role in ARI. Among 237 respiratory samples, 10 samples were detected positive for HBoV, with 4 as mono-infections and 6 as co-infections with other viruses. All the patients were less than 3 years old and had different co-morbid conditions. The study emphasizes the need for larger studies to confirm the true pathogenicity of HBoV in childhood ARI.
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2023)
Review
Immunology
Rashmi Ranjan Das, Bijayini Behera, Baijayantimala Mishra, Sushree Samiksha Naik
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2020)
Article
Nutrition & Dietetics
Rashmi Ranjan Das, Manaswini Mangaraj, Sandeep Kumar Panigrahi, Amit Kumar Satapathy, Samarendra Mahapatro, Partha Sarathi Ray
FRONTIERS IN NUTRITION
(2020)
Article
Medicine, General & Internal
Amit Satapathy, Basudev Biswal, Lipsa Priyadarshini, Chandrasekhar Sirka, Lipsa Das, Pritinanda Mishra, Sujata Patodia, Subhashree Kar, Samarendra Mahapatro, Rashmi R. Das
CUREUS JOURNAL OF MEDICAL SCIENCE
(2020)
Article
Pediatrics
Vishwanath Ghoshal, Rashmi Ranjan Das, Manas Kumar Nayak, Snigdha Singh, Palash Das, Nirmal Kumar Mohakud
FRONTIERS IN PEDIATRICS
(2020)
Article
Pediatrics
Kiran Kumar Banothu, Javeed Iqbal Bhat, Rashmi Ranjan Das, Nitin Dhochak, Jagat Jeevan Ghimire, Jagdish P. Goyal, Krishna Mohan Gulla, Samriti Gupta, Kana Ram Jat, Sushil K. Kabra, Pawan Kalyan, Arvind Kumar, Prawin Kumar, Vijay Kumar, Rakesh Lodha, Joseph L. Mathew, Amit Pathania, Vinod H. Ratageri, Varinder Singh, Sagar Warankar
Review
Pediatrics
Nihar R. Mishra, Manoj K. Panigrahi, Girish C. Bhatt, Rashmi R. Das
CURRENT PEDIATRIC REVIEWS
(2020)
Review
Pediatrics
Rashmi Ranjan Das, Jhuma Sankar, Sushil Kumar Kabra
CURRENT PEDIATRIC REVIEWS
(2019)
Article
Infectious Diseases
Sandeep Kumar Tripathy, Pravakar Mishra, Bhagirathi Dwibedi, Lipsa Priyadarshini, Rashmi Ranjan Das
JOURNAL OF GLOBAL INFECTIOUS DISEASES
(2019)