The epigenetic dysfunction underlying malignant glioma pathogenesis
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The epigenetic dysfunction underlying malignant glioma pathogenesis
Authors
Keywords
-
Journal
LABORATORY INVESTIGATION
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-02-12
DOI
10.1038/s41374-022-00741-7
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A phase I study of LY3410738, a first-in-class covalent inhibitor of mutant IDH1 in cholangiocarcinoma and other advanced solid tumors.
- (2021) James Michael Pauff et al. JOURNAL OF CLINICAL ONCOLOGY
- Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants
- (2021) Raul Bardini Bressan et al. Cell Stem Cell
- Phase I assessment of safety and therapeutic activity of BAY1436032 in patients with IDH1-mutant solid tumors
- (2021) Antje Wick et al. CLINICAL CANCER RESEARCH
- Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors
- (2021) Philipp Sievers et al. ACTA NEUROPATHOLOGICA
- Vorasidenib, a Dual Inhibitor of Mutant IDH1/2, in Recurrent or Progressive Glioma; Results of a First-in-Human Phase I Trial
- (2021) Ingo K. Mellinghoff et al. CLINICAL CANCER RESEARCH
- Rates and patterns of clonal oncogenic mutations in the normal human brain
- (2021) Javier Ganz et al. Cancer Discovery
- Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor
- (2020) Justin A. Caravella et al. JOURNAL OF MEDICINAL CHEMISTRY
- Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma
- (2020) Zenon Konteatis et al. ACS Medicinal Chemistry Letters
- IDH mutation in glioma: molecular mechanisms and potential therapeutic targets
- (2020) Sue Han et al. BRITISH JOURNAL OF CANCER
- Oncometabolites suppress DNA repair by disrupting local chromatin signalling
- (2020) Parker L. Sulkowski et al. NATURE
- Ivosidenib or enasidenib combined with intensive chemotherapy in patients with newly diagnosed AML: a phase 1 study
- (2020) Eytan M. Stein et al. BLOOD
- Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis
- (2020) Carol C.L. Chen et al. CELL
- ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis
- (2019) Christine M. Hoeman et al. Nature Communications
- First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematological Cancers: Results of a Phase I Dose Escalation Study
- (2019) Amit Khot et al. Cancer Discovery
- Histone H3 Mutations: An Updated View of Their Role in Chromatin Deregulation and Cancer
- (2019) Brandon R. Lowe et al. Cancers
- Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course
- (2019) Annika K. Wefers et al. ACTA NEUROPATHOLOGICA
- Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG
- (2019) Jamie N. Anastas et al. CANCER CELL
- Epigenetic reprogramming and chromatin accessibility in pediatric diffuse intrinsic pontine gliomas: a neural developmental disease
- (2019) Flor M Mendez et al. NEURO-ONCOLOGY
- cIMPACT-NOW update 2: diagnostic clarifications for diffuse midline glioma, H3 K27M-mutant and diffuse astrocytoma/anaplastic astrocytoma, IDH-mutant
- (2018) David N. Louis et al. ACTA NEUROPATHOLOGICA
- Novel, improved grading system(s) for IDH-mutant astrocytic gliomas
- (2018) Mitsuaki Shirahata et al. ACTA NEUROPATHOLOGICA
- Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations
- (2018) Annekathrin Reinhardt et al. ACTA NEUROPATHOLOGICA
- Mutant IDH1 Cooperates with ATRX Loss to Drive the Alternative Lengthening of Telomere Phenotype in Glioma
- (2018) Joydeep Mukherjee et al. CANCER RESEARCH
- DNA methylation-based classification of central nervous system tumours
- (2018) David Capper et al. NATURE
- Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M+ diffuse midline gliomas
- (2018) Christopher W. Mount et al. NATURE MEDICINE
- Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers
- (2018) Janeta Popovici-Muller et al. ACS Medicinal Chemistry Letters
- Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling
- (2018) Carla Danussi et al. Nature Communications
- Mutant IDH1 Promotes Glioma Formation In Vivo
- (2018) Beatrice Philip et al. Cell Reports
- Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3–MutSα interaction
- (2018) Jun Fang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells
- (2018) Alessio De Magis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis
- (2017) Felix Sahm et al. LANCET ONCOLOGY
- Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression
- (2017) Christopher J. Pirozzi et al. MOLECULAR CANCER RESEARCH
- CAR T Cells Administered in Combination with Lymphodepletion and PD-1 Inhibition to Patients with Neuroblastoma
- (2017) Andras Heczey et al. MOLECULAR THERAPY
- Systematic analysis of telomere length and somatic alterations in 31 cancer types
- (2017) Floris P Barthel et al. NATURE GENETICS
- Clonal expansion and epigenetic reprogramming following deletion or amplification of mutantIDH1
- (2017) Tali Mazor et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity
- (2017) Parker L. Sulkowski et al. Science Translational Medicine
- Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor
- (2017) Young Shin Cho et al. ACS Medicinal Chemistry Letters
- Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX
- (2017) Dominik Hoelper et al. Nature Communications
- AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations
- (2017) Katharine Yen et al. Cancer Discovery
- Evidence of H3 K27M mutations in posterior fossa ependymomas
- (2016) Marco Gessi et al. ACTA NEUROPATHOLOGICA
- Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway
- (2016) Jason T. Huse et al. ACTA NEUROPATHOLOGICA
- Expression of Idh1R132H in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis
- (2016) Chiara Bardella et al. CANCER CELL
- New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs
- (2016) Dominik Sturm et al. CELL
- Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
- (2016) Michele Ceccarelli et al. CELL
- Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase
- (2016) Shuang Yang et al. GENES & DEVELOPMENT
- Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study
- (2016) Brigitta G Baumert et al. LANCET ONCOLOGY
- Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
- (2016) Neil Justin et al. Nature Communications
- The Role of ATRX in the Alternative Lengthening of Telomeres (ALT) Phenotype
- (2016) João Amorim et al. Genes
- Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion
- (2015) Kensuke Tateishi et al. CANCER CELL
- Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups
- (2015) Kristian W. Pajtler et al. CANCER CELL
- CDKN2ALoss Is Associated With Shortened Overall Survival in Lower-Grade (World Health Organization Grades II–III) Astrocytomas
- (2015) Gerald F. Reis et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Insulator dysfunction and oncogene activation in IDH mutant gliomas
- (2015) William A. Flavahan et al. NATURE
- Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas
- (2015) NEW ENGLAND JOURNAL OF MEDICINE
- Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2
- (2015) L. Jiao et al. SCIENCE
- Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma
- (2015) Kasthuri Kannan et al. Oncotarget
- Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.
- (2015) Sevin Turcan et al. Oncotarget
- Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas
- (2014) Denise Bechet et al. ACTA NEUROPATHOLOGICA
- ATRX promotes gene expression by facilitating transcriptional elongation through guanine-rich coding regions
- (2014) Michael A. Levy et al. HUMAN MOLECULAR GENETICS
- Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing
- (2014) Volker Hovestadt et al. NATURE
- IDH2mutation in gliomas including novel mutation
- (2014) Jaemoon Koh et al. NEUROPATHOLOGY
- ATRX Dysfunction Induces Replication Defects in Primary Mouse Cells
- (2014) David Clynes et al. PLoS One
- Modeling Adult Gliomas Using RCAS/t-va Technology
- (2014) Dolores Hambardzumyan et al. Translational Oncology
- Histone H3 Mutations in Pediatric Brain Tumors
- (2014) X. Liu et al. Cold Spring Harbor Perspectives in Biology
- Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays
- (2013) Volker Hovestadt et al. ACTA NEUROPATHOLOGICA
- What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
- (2013) J.-A. Losman et al. GENES & DEVELOPMENT
- Expanding the spectrum of IDH1 mutations in gliomas
- (2013) Ruta Gupta et al. MODERN PATHOLOGY
- Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma
- (2013) P. W. Lewis et al. SCIENCE
- Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN
- (2013) Lynn Bjerke et al. Cancer Discovery
- Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations
- (2012) Xiao-Yang Liu et al. ACTA NEUROPATHOLOGICA
- K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
- (2012) Dong-Anh Khuong-Quang et al. ACTA NEUROPATHOLOGICA
- Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma
- (2012) Dominik Sturm et al. CANCER CELL
- ATRX-mediated chromatin association of histone variant macroH2A1 regulates -globin expression
- (2012) K. Ratnakumar et al. GENES & DEVELOPMENT
- D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function
- (2012) M. Sasaki et al. GENES & DEVELOPMENT
- IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
- (2012) Sevin Turcan et al. NATURE
- Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
- (2012) Jeremy Schwartzentruber et al. NATURE
- Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
- (2012) Gang Wu et al. NATURE GENETICS
- Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics
- (2012) Mustapha Haddach et al. ACS Medicinal Chemistry Letters
- Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
- (2011) C. U. Louis et al. BLOOD
- Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
- (2011) Wei Xu et al. CANCER CELL
- The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
- (2011) Rasheduzzaman Chowdhury et al. EMBO REPORTS
- The Polycomb complex PRC2 and its mark in life
- (2011) Raphaël Margueron et al. NATURE
- MGMT promoter methylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastoma
- (2011) A. L. Rivera et al. NEURO-ONCOLOGY
- Identification of additional IDH mutations associated with oncometabolite R(−)-2-hydroxyglutarate production
- (2011) P S Ward et al. ONCOGENE
- Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma
- (2010) Houtan Noushmehr et al. CANCER CELL
- Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
- (2010) Maria E. Figueroa et al. CANCER CELL
- Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth
- (2010) Denis Drygin et al. CANCER RESEARCH
- The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3
- (2010) P. Drane et al. GENES & DEVELOPMENT
- Alternative lengthening of telomeres: models, mechanisms and implications
- (2010) Anthony J. Cesare et al. NATURE REVIEWS GENETICS
- IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas
- (2010) C. Houillier et al. NEUROLOGY
- Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres
- (2010) P. W. Lewis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Monoclonal antibody specific for IDH1 R132H mutation
- (2009) David Capper et al. ACTA NEUROPATHOLOGICA
- Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
- (2009) Lenny Dang et al. NATURE
- IDH1andIDH2Mutations in Gliomas
- (2009) Hai Yan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
- (2008) William G. Kaelin et al. MOLECULAR CELL
- Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma
- (2008) Martin A Pule et al. NATURE MEDICINE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started