Programmable motion control and trajectory manipulation of microparticles through tri-directional symmetrical acoustic tweezers

Acoustic tweezers based on travelling surface acoustic waves (TSAWs) have the potential for contactless trajectory manipulation and motion-parameter regulation of microparticles in biological and microfluidic applications. Here, we present a novel design of a tri-directional symmetrical acoustic tweezers device that enables the precise manipulation of linear, clockwise, and anticlockwise trajectories of microparticles. By switching the excitation combinations of interdigital electrodes (IDTs), various shape patterns of acoustic pressure fields can be formed to capture and steer microparticles accurately according to pre-defined trajectories. Numerical simulations and experimental tests were conducted in this study. By adjusting the input electric signals and the fluid's viscosity, the device is able to manipulate microparticles of various forms as well as brine shrimp egg cells with the accurate modulation of motion parameters. The results show that the proposed programmable design possesses low-cost, compact, non-contact, and high biocompatibility benefits, with the capacity to accurately manage microparticles in a range of motion trajectories, independent of their physical and/or chemical characteristics. Thus, our design has strong potential applications in chemical composition analysis, drug delivery, and cell assembly.

Automated summary

This article presents a novel design of a tri-directional symmetrical acoustic tweezers device that enables precise manipulation of linear, clockwise, and anticlockwise trajectories of microparticles. By adjusting the input electric signals and the fluid's viscosity, the device is able to accurately modulate the motion parameters and manipulate various forms of microparticles as well as brine shrimp egg cells.