Specific disruption of calcineurin-signaling in the distal convoluted tubule impacts the transcriptome and proteome, and causes hypomagnesemia and metabolic acidosis

Claudins in Renal Physiology and Pathology

(2020) Caroline Prot-Bertoye et al.   Genes

THIRTY YEARS OF TACROLIMUS IN CLINICAL PRACTICE

(2020) Song C. Ong et al.   TRANSPLANTATION

Calcineurin

(2020) Trevor P. Creamer   Cell Communication and Signaling

Deletion of the transcription factor Prox-1 specifically in the renal distal convoluted tubule causes hypomagnesemia via reduced expression of TRPM6 and NCC

(2020) Christina Schnoz et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Calcineurin dephosphorylates Kelch-like 3, reversing phosphorylation by angiotensin II and regulating renal electrolyte handling

(2019) Kenichi Ishizawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug-Induced Hypertension

(2019) Matthew C. Foy et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Loss of sodium chloride co-transporter impairs the outgrowth of the renal distal convoluted tubule during renal development

(2019) Christina Schnoz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Renal function of cyclin M2 Mg2+ transporter maintains blood pressure

(2017) Yosuke Funato et al.   JOURNAL OF HYPERTENSION

Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes

(2017) Tanguy Corre et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Calcineurin inhibitors block sodium-chloride cotransporter dephosphorylation in response to high potassium intake

(2017) Wakana Shoda et al.   KIDNEY INTERNATIONAL

NaCl cotransporter abundance in urinary vesicles is increased by calcineurin inhibitors and predicts thiazide sensitivity

(2017) Omar A. Z. Tutakhel et al.   PLoS One

Extracellular K+rapidly controls NaCl cotransporter phosphorylation in the native distal convoluted tubule by Cl−-dependent and independent mechanisms

(2016) David Penton et al.   JOURNAL OF PHYSIOLOGY-LONDON

Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors

(2016) Michael M. Kaminski et al.   NATURE CELL BIOLOGY

Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival

(2016) Vladimir Chubanov et al.   eLife

The Role of Epithelial Sodium Channel ENaC and the Apical Cl-/HCO3- Exchanger Pendrin in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC) Inactivation

(2016) Mina Patel-Chamberlin et al.   PLoS One

Identification of SLC41A3 as a novel player in magnesium homeostasis

(2016) Jeroen H.F. de Baaij et al.   Scientific Reports

Mitochondrial Mg2+ homeostasis decides cellular energy metabolism and vulnerability to stress

(2016) Ryu Yamanaka et al.   Scientific Reports

Calcineurin Links Mitochondrial Elongation with Energy Metabolism

(2015) Paul T. Pfluger et al.   Cell Metabolism

Integrated compensatory network is activated in the absence of NCC phosphorylation

(2015) P. Richard Grimm et al.   JOURNAL OF CLINICAL INVESTIGATION

Renal Deletion of 12 kDa FK506-Binding Protein Attenuates Tacrolimus-Induced Hypertension

(2015) R. A. Lazelle et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes

(2015) J. W. Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

(2015) Tomokazu Murakawa et al.   Nature Communications

ProteomeXchange provides globally coordinated proteomics data submission and dissemination

(2014) Juan A Vizcaíno et al.   NATURE BIOTECHNOLOGY

Working Memory Impairment in Calcineurin Knock-out Mice Is Associated with Alterations in Synaptic Vesicle Cycling and Disruption of High-Frequency Synaptic and Network Activity in Prefrontal Cortex

(2013) J. R. Cottrell et al.   JOURNAL OF NEUROSCIENCE

Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice

(2013) Mads V. Sorensen et al.   KIDNEY INTERNATIONAL

Magnesium loss in cyclosporine-treated patients is related to renal epidermal growth factor downregulation

(2013) K. J. Ledeganck et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

CNNM2, Encoding a Basolateral Protein Required for Renal Mg2+ Handling, Is Mutated in Dominant Hypomagnesemia

(2011) Marchel Stuiver et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Effects of Cyclosporine, Tacrolimus and Rapamycin on Renal Calcium Transport and Vitamin D Metabolism

(2011) Chien-Te Lee et al.   AMERICAN JOURNAL OF NEPHROLOGY

Cyclosporine metabolic side effects: association with the WNK4 system

(2011) Semyon Melnikov et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension

(2011) Ewout J Hoorn et al.   NATURE MEDICINE

Genomic-Derived Markers for Early Detection of Calcineurin Inhibitor Immunosuppressant–Mediated Nephrotoxicity

(2011) Yuxia Cui et al.   TOXICOLOGICAL SCIENCES

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE