Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus

Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic

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Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China

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α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

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Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

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A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

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A new coronavirus associated with human respiratory disease in China

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A Novel Coronavirus from Patients with Pneumonia in China, 2019

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Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

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The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

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Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur

(2020) Zhenming Jin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

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Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

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Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

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Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode

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Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element

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Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

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Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome Coronavirus

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Coronaviruses — drug discovery and therapeutic options

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Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design

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Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro)

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A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

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Bat origin of human coronaviruses

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Evidence Supporting a Zoonotic Origin of Human Coronavirus Strain NL63

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A Structural Study of Norovirus 3C Protease Specificity: Binding of a Designed Active Site-Directed Peptide Inhibitor

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Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode

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