Genetic deletion of platelet PAR4 results in reduced thrombosis and impaired hemostatic plug stability

Platelet Activation and Chemokine Release Are Related to Local Neutrophil-Dominant Inflammation During Hyperacute Human Stroke

(2021) Alexander M. Kollikowski et al.   Translational Stroke Research

Loss of Protease-Activated Receptor 4 Prevents Inflammation Resolution and Predisposes the Heart to Cardiac Rupture after Myocardial Infarction

(2020) Mikhail A. Kolpakov et al.   CIRCULATION

Model‐dependent contributions of FXII and FXI to venous thrombosis in mice

(2020) Steven P Grover et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Protease-activated receptor 4 protects mice from Coxsackievirus B3 and H1N1 influenza A virus infection

(2019) Kohei Tatsumi et al.   CELLULAR IMMUNOLOGY

Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function

(2019) Qi Peng et al.   Frontiers in Immunology

Using PAR4 Inhibition as an Anti-Thrombotic Approach: Why, How, and When?

(2019) Simeng Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PAR4 (Protease-Activated Receptor 4)

(2018) Xu Han et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Roles of Coagulation Proteases and PARs (Protease-Activated Receptors) in Mouse Models of Inflammatory Diseases

(2018) Jens J. Posma et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Protease-Mediated Suppression of DRG Neuron Excitability by Commensal Bacteria

(2017) Jessica L. Sessenwein et al.   JOURNAL OF NEUROSCIENCE

GuideScan software for improved single and paired CRISPR guide RNA design

(2017) Alexendar R Perez et al.   NATURE BIOTECHNOLOGY

PAR4 (Protease-Activated Receptor 4) Antagonism With BMS-986120 Inhibits Human Ex Vivo Thrombus Formation

(2017) Simon J. Wilson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on HemostasisHighlights

(2016) Raymond Piatt et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Protease-activated receptor 4: from structure to function and back again

(2016) Shauna L French et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of ibrutinib treatment on murine platelet function during inflammation and in primary hemostasis

(2016) Robert H. Lee et al.   HAEMATOLOGICA

Protease-Activated Receptor 1 Enhances Poly I:C Induction of the Antiviral Response in Macrophages and Mice

(2016) Silvio Antoniak et al.   Journal of Innate Immunity

Effects of ibrutinib treatment on murine platelet function during inflammation and in primary hemostasis

(2016) Robert H. Lee et al.   HAEMATOLOGICA

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

(2015) Lucia Stefanini et al.   JOURNAL OF CLINICAL INVESTIGATION

Down in a hole: a new laser ablation model of hemostasis

(2015) K. B. Neeves   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Novel mouse hemostasis model for real-time determination of bleeding time and hemostatic plug composition

(2015) T. M. Getz et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool

(2015) Manuel Stemmer et al.   PLoS One

Redundancy and Interaction of Thrombin- and Collagen-Mediated Platelet Activation in Tail Bleeding and Carotid Thrombosis in Mice

(2014) Yamini S. Bynagari-Settipalli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Thrombin Receptor Protease-Activated Receptor 4 Is a Key Regulator of Exaggerated Intimal Thickening in Diabetes Mellitus

(2014) Goran Pavic et al.   CIRCULATION

Blockade of proteinase-activated receptor 4 inhibits neutrophil recruitment in experimental inflammation in mice

(2014) Lindisley F. Gomides et al.   INFLAMMATION RESEARCH

Combined In Vivo Depletion of Glycoprotein VI and C-Type Lectin-Like Receptor 2 Severely Compromises Hemostasis and Abrogates Arterial Thrombosis in Mice

(2013) Markus Bender et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

LIM kinase-1 selectively promotes glycoprotein Ib-IX-mediated TXA2 synthesis, platelet activation, and thrombosis

(2013) B. Estevez et al.   BLOOD

PAR-1 contributes to the innate immune response during viral infection

(2013) Silvio Antoniak et al.   JOURNAL OF CLINICAL INVESTIGATION

Safety and efficacy of targeting platelet proteinase-activated receptors in combination with existing anti-platelet drugs as antithrombotics in mice

(2012) H Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rap1-Rac1 Circuits Potentiate Platelet Activation

(2011) Lucia Stefanini et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Protease-activated receptors and myocardial infarction

(2011) Silvio Antoniak et al.   IUBMB LIFE

Towards a standardization of the murine ferric chloride-induced carotid arterial thrombosis model

(2011) A. P. OWENS III et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The contribution of thrombin-induced platelet activation to thrombus growth is diminished under pathological blood shear conditions

(2011) Hannah Lee et al.   THROMBOSIS AND HAEMOSTASIS

Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice

(2010) R. Pawlinski et al.   BLOOD

Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis

(2010) I. Cornelissen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Triggers, targets and treatments for thrombosis

(2008) Nigel Mackman   NATURE