Review
Cell Biology
Shivalika Khanduja, Jiah Kim, Jin Kook Kang, Cheng-Yuan Feng, Melissa Ann Vogelsong, Romergryko G. Geocadin, Glenn Whitman, Sung-Min Cho
Summary: Extracorporeal membrane oxygenation (ECMO) carries a significant risk of hypoxic-ischemic brain injury (HIBI), which is one of the most common types of acute brain injury in ECMO patients. Various risk factors have been associated with the development of HIBI in ECMO patients, and the pathogenic mechanisms are complex and multifactorial. Current therapeutics focus on targeting pathological mechanisms and optimizing cerebral oxygenation and perfusion to improve neurological outcomes in ECMO patients and minimize the morbidity of HIBI.
Article
Medicine, General & Internal
David Gonzalez-Martin, Mario Herrera-Perez, Jorge Ojeda-Jimenez, Diego Rendon-Diaz, Victor Valderrabano, Jose Luis Pais-Brito
Summary: The study investigated the incidence of neurological injuries after calcaneal osteotomies and found that the sural nerve was most affected. Following the safe zone during surgeries significantly reduced the incidence of sural nerve injury, and there were no significant differences in functional tests and patient satisfaction among different surgical techniques.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Critical Care Medicine
Elisa Gouvea Bogossian, Alberto Diosdado, Sami Barrit, Mejdeddine Al Barajraji, Filippo Annoni, Sophie Schuind, Fabio Silvio Taccone
Summary: The objective of this study was to summarize the impact of PbtO(2)-guided therapy on the outcome of patients with TBI. By analyzing 15 studies, it was found that PbtO(2)-guided therapy was associated with better neurological outcomes and higher hospital survival rate. However, the overall quality of the studies was low.
NEUROCRITICAL CARE
(2022)
Article
Medicine, General & Internal
Daniel Pinggera, Paul Rhomberg, Ronny Beer, Claudius Thome, Ondra Petr
Summary: This study evaluated the impact of in situ neuromonitoring devices on brain tissue damage and its clinical relevance. The results showed that neuromonitoring probes in situ during MRI examinations may cause local brain tissue damage, but if placed correctly, they do not have any clinical implications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Chien-Sing Poon, Benjamin Rinehart, Dharminder S. Langri, Timothy M. Rambo, Aaron J. Miller, Brandon Foreman, Ulas Sunar
Summary: This study aims to provide a noninvasive, bedside, continuous cerebral blood flow monitoring approach in the neurointensive care unit through combined measurements of EEG and functional optical spectroscopy. The use of diffuse correlation spectroscopy method for assessing cerebral blood flow in a patient with traumatic brain injury demonstrated the feasibility of continuous recording of noninvasive cerebral blood flow transients that correlated well with gold-standard invasive measurements and changes in EEG data frequency content.
Article
Engineering, Biomedical
Simon Baumgartner, Matthias Lubnow, Maximilian Valentin Malfertheiner, Alois Philipp, Maik Foltan, Dirk Lunz, Thomas Mueller, Christoph Fisser
Summary: This study aimed to assess the prevalence of bleeding and thromboembolic events in veno-venous extracorporeal membrane oxygenation (vvECMO) for isolated respiratory failure. The study found that major bleeding occurred in 73% of patients, with 35% of bleeding events happening on the day of or after ECMO initiation. Thromboembolic events were noted in 30% of patients.
Article
Medicine, General & Internal
Stany Sandrio, Manfred Thiel, Joerg Krebs
Summary: We investigated the association between pre-ECMO liver impairment, V-VA ECMO support, and mortality in patients undergoing ECMO treatment. We found that a higher pre-ECMO MELD score independently predicts mortality, and V-VA ECMO is associated with a higher mortality risk in patients with a pre-ECMO MELD score >16. These findings suggest the importance of assessing liver function and considering the type of ECMO support in predicting and managing mortality risk.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Xiaobei Shi, Qiao Gu, Yiwei Li, Mengyuan Diao, Xin Wen, Wei Hu, Shaosong Xi
Summary: This study investigated the role of a multimodal neurological monitoring (MNM)-guided protocol in venoarterial extracorporeal membrane oxygenation (VA-ECMO) supported patients. The results showed that the MNM-guided protocol plays an important role in the precision identification of neural impairment and long-term neurological outcomes in these patients.
FRONTIERS IN MEDICINE
(2022)
Article
Critical Care Medicine
Nicholas A. Fergusson, Ryan L. Hoiland, Sonny Thiara, Denise Foster, Peter Gooderham, Kiran Rikhraj, Brian Grunau, Jim Christenson, Philip N. Ainslie, Donald E. G. Griesdale, Mypinder S. Sekhon
Summary: In adult patients with return of spontaneous circulation post-cardiac arrest, targeted therapy for hypoxic ischemic brain injury may improve neurological outcomes.
CRITICAL CARE MEDICINE
(2021)
Article
Respiratory System
Armaan Akbar, Benjamin Shou, Cheng-Yuan Feng, David Zhao, Bo Soo Kim, Glenn Whitman, Errol Bush, Sung-Min Cho, HERALD Investigators
Summary: This study examined the relationship between arterial oxygen tension and carbon dioxide tension and acute brain injury in patients receiving veno-venous extracorporeal membrane oxygenation. The results showed that lower post-cannulation oxygen tension was associated with intracranial hemorrhage. Therefore, further investigation is needed to understand the role of arterial blood gas changes during the procedure for better management of these patients.
Article
Critical Care Medicine
Roberto Lorusso, Mirko Belliato, Michael Mazzeffi, Michele Di Mauro, Fabio Silvio Taccone, Orlando Parise, Ayat Albanawi, Veena Nandwani, Paul McCarthy, Zachary Kon, Jay Menaker, Daniel M. Johnson, Sandro Gelsomino, Daniel Herr
Summary: Neurological complications in patients undergoing V-V ECMO were found to be unrelated to the type of cannulation according to a large registry study.
Review
Clinical Neurology
Hassan Aboul-Nour, Ammar Jumah, Hafsa Abdulla, Amreeta Sharma, Bradley Howell, Namita Jayaprakash, Jayna Gardner-Gray
Summary: This narrative literature review examines the challenges and strategies for neurological monitoring in ECMO patients. The literature is limited and lacks consensus on optimal monitoring practices. Additional studies are needed to identify effective measures of neurological monitoring while on ECMO.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Cardiac & Cardiovascular Systems
Richard Saczkowski, Nick Kuzak, Brian Grunau, Costas Schulze
Summary: The study analyzed 658 cases of severe accidental hypothermia treated with ECLS and found that slower rewarming rates were associated with improved survival with good neurological outcomes. A rewarming rate of <= 5.0 degrees C/h may lead to better clinical outcomes.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Review
Clinical Neurology
Jennifer C. Laws, Lori C. Jordan, Lindsay M. Pagano, John C. Wellons, Michael S. Wolf
Summary: Children with acute neurologic illness are at high risk of mortality and long-term neurologic disability. However, there is a lack of targeted neuroprotective therapies for these conditions, so management primarily focuses on close physiologic monitoring and supportive care. This review explores advanced neurologic monitoring strategies and recent innovations to prevent neurologic sequelae in critically ill pediatric patients.
PEDIATRIC NEUROLOGY
(2022)
Article
Anesthesiology
Sergio Brasil, Gustavo Frigieri, Fabio Silvio Taccone, Chiara Robba, Davi Jorge Fontoura Solla, Ricardo de Carvalho Nogueira, Marcia Harumy Yoshikawa, Manoel Jacobsen Teixeira, Luiz Marcelo Sa Malbouisson, Wellingson Silva Paiva
Summary: This study assessed the correlation between noninvasive intracranial pressure waveforms (NICPW) and invasively measured intracranial pressure (ICP), as well as the prognostic value of NICPW in acute brain-injured patients. The results showed a significant correlation between NICPW and ICP, and the NICPW-derived P2/P1 ratio could predict intracranial hypertension and early death.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Review
Critical Care Medicine
Shaurya Taran, Sung-Min Cho, Robert D. Stevens
Summary: This narrative review summarizes the existing evidence for mechanical ventilation in patients with traumatic brain injury (TBI). It emphasizes the importance of ventilation strategies and highlights the knowledge gaps that require further research.
NEUROCRITICAL CARE
(2023)
Article
Critical Care Medicine
Benjamin L. Shou, Christopher Wilcox, Isabella Florissi, Andrew Kalra, Giorgio Caturegli, Lucy Q. Zhang, Errol Bush, Bo Kim, Steven P. Keller, Glenn J. R. Whitman, Sung-Min Cho
Summary: This study explored the impact of early low pulse pressure on the occurrence of acute brain injury (ABI) in patients on venoarterial extracorporeal membrane oxygenation (VA-ECMO). The results showed that low pulse pressure was independently associated with ABI. The study also suggested that low pulse pressure may serve as a marker for ABI risk, highlighting the importance of close neuromonitoring for early detection.
NEUROCRITICAL CARE
(2023)
Article
Cardiac & Cardiovascular Systems
Benjamin L. Shou, Chin Siang Ong, Lavienraj Premraj, Patricia Brown, Joseph E. Tonna, Heidi J. Dalton, Bo Soo Kim, Steven P. Keller, Glenn J. R. Whitman, Sung -Min Cho
Summary: Using a large multicenter cohort, this study investigated the impact of peri-cannulation arterial oxygen (PaO2) and carbon dioxide (PaCO2) on acute brain injury (ABI) occurrence after extracorporeal cardiopulmonary resuscitation (ECPR). Multivariable logistic regression analysis was conducted to assess the relationship between PaO2, PaCO2, and ABI, with missing values handled using multiple imputation.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Critical Care Medicine
Shaurya Taran, Camilo Diaz-Cruz, Bastien Perrot, Pablo Alvarez, Daniel Agustin Godoy, Mohan Gurjar, Matthias Haenggi, Julio Cesar Mijangos, Paolo Pelosi, Chiara Robba, Marcus J. Schultz, Yoshitoyo Ueno, Karim Asehnoune, Sung-Min Cho, Christopher J. Yarnell, Raphael Cinotti, Robert D. Stevens
Summary: This study found that prophylactic use of high-flow nasal cannula (HFNC) and noninvasive positive pressure ventilation (NIPPV) was not associated with reintubation in patients with acute brain injury undergoing liberation from mechanical ventilation. Prospective trials are needed to confirm treatment effects in this population.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Engineering, Biomedical
Neel Shah, Bing Xue, Ziqi Xu, Hanqing Yang, Eva Marwali, Heidi Dalton, Philip P. R. Payne, Chenyang S. Lu, Ahmed Said
Summary: In this study, several ECMO mortality prediction and severity of illness scores were validated for a large COVID-19 V-V ECMO cohort. The results showed inconsistent discrimination and calibration of these scores, highlighting the need for better clinically applicable decision support tools.
Article
Biotechnology & Applied Microbiology
Mengxuan Zou, Shuo Dong, Shun Liu, Chuhao Du, Yangxue Sun, Jie Dong, Haitao Xu, Jun Yan
Summary: This study aimed to identify factors affecting the prognosis of children with pulmonary valve atresia and intact ventricular septum treated with transthoracic balloon dilation. The study included 148 participants who were followed up for 5 years. It was found that tricuspid regurgitation, pulmonary valve pressure difference, length of stay, reoperation intervention, and complications were independent risk factors affecting the prognosis.
BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS
(2023)
Review
Critical Care Medicine
Denise Battaglini, Elisa Gouvea Bogossian, Pasquale Anania, Lavienraj Premraj, Sung-Min Cho, Fabio Silvio Taccone, Mypinder Sekhon, Chiara Robba
Summary: Cardiac arrest is a sudden event that often leads to brain injury and high mortality rates. Brain tissue oxygenation (PbtO(2)) is a tool used to monitor brain oxygen levels, but its effectiveness is still unclear. A systematic review was conducted to understand the role of PbtO(2) in monitoring brain oxygenation in patients with cardiac arrest and the impact of targeted PbtO(2) therapy on outcomes.
NEUROCRITICAL CARE
(2023)
Article
Cardiac & Cardiovascular Systems
Fausto Biancari, Alexander Kaserer, Andrea Perrotti, Vito G. Ruggieri, Sung-Min Cho, Jin Kook Kang, Magnus Dalen, Henryk Welp, Kristjan Jonsson, Sigurdur Ragnarsson, Francisco J. Hernandez Perez, Giuseppe Gatti, Khalid Alkhamees, Antonio Loforte, Andrea Lechiancole, Stefano Rosato, Cristiano Spadaccio, Matteo Pettinari, Giovanni Mariscalco, Timo Makikallio, Sebastian D. Sahli, Camilla L'Acqua, Amr A. Arafat, Monirah A. Albabtain, Mohammed M. AlBarak, Mohamed Laimoud, Ilija Djordjevic, Ihor Krasivskyi, Robertas Samalavicius, Lina Puodziukaite, Marta Alonso-Fernandez-Gatta, Donat R. Spahn, Antonio Fiore
Summary: This study evaluated the association between pre-V-A-ECMO arterial lactate level and in-hospital mortality in postcardiotomy patients. The results showed that increased arterial lactate level before V-A-ECMO initiation was associated with higher in-hospital mortality. Therefore, arterial lactate level may be useful in guiding the decision-making process and timing of initiation of postcardiotomy V-A-ECMO.
Article
Surgery
Shuo Dong, Chuhao Du, Jiangping Song, Jie Dong, Hong Meng, Haitao Xu, Yangxue Sun, Mengxuan Zou, Shoujun Li, Jun Yan
Summary: This study reports the outcomes after septal myectomy in young children and infants with hypertrophic obstructive cardiomyopathy (HOCM), and identifies the mechanisms of residual or recurrent obstruction after surgery. The study found that septal myectomy is still effective and safe in young children and infants, but the rate of residual or recurrent obstruction with diverse causes is relatively high, particularly in patients younger than 2 years at surgery and those with biventricular outflow obstruction.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Engineering, Biomedical
Anna Peeler, Patricia M. Davidson, Kelly T. Gleason, R. Scott Stephens, Betty Ferrell, Bo Soo Kim, Sung-Min Cho
Summary: This study investigated the application of palliative care (PC) in patients on extracorporeal membrane oxygenation (ECMO). The findings showed that PC is underused in this population, despite its important role in improving patients' quality of life.
Article
Engineering, Biomedical
Henry Shu, Sung-min Cho, Andrew Harris, Meghana L. Jami, Benjamin J. Shou, Matthew M. Griffee, Akram J. Zaaqoq, Christopher Wilcox, Marc Anders, Peter Rycus, Glenn Whitman, Bo Soo Kim, Babar Shafiq
Summary: The study aimed to investigate whether fasciotomy is associated with increased mortality in patients with acute compartment syndrome (ACS) on extracorporeal cardiopulmonary resuscitation (ECPR). The retrospective study analyzed data from adult ECPR patients diagnosed with ACS between 2013 and 2021. The results showed no significant difference in mortality between ACS patients with and without fasciotomy. Body mass index (BMI) and 24-hour mean blood pressure were identified as independent risk factors for mortality. Prospective studies are needed to confirm these findings and guide surgical decision-making for ACS patients after ECPR.
Article
Critical Care Medicine
Merry Huang, Aron Gedansky, Catherine E. Hassett, Aaron Shoskes, Abhijit Duggal, Ken Uchino, Sung-Min Cho, Andrew B. Buletko
Summary: This study retrospectively analyzed the structural brain injuries detected by brain MRI among patients with ARDS at a single tertiary center in the United States from January 2010 to October 2018 (pre-COVID era). The results showed that bilateral globus pallidus infarcts and diffuse rather than focal hemorrhage were more common in patients with ARDS. The study suggests that structural brain injuries exist in patients with ARDS.
NEUROCRITICAL CARE
(2023)
Article
Critical Care Medicine
Sung-Min Cho, Chiara Robba, Michael N. Diringer, Daniel F. Hanley, J. Claude Hemphill, Janneke Horn, Ariane Lewis, Sarah L. Livesay, David Menon, Tarek Sharshar, Robert D. Stevens, James Torner, Paul M. Vespa, Wendy C. Ziai, Marcus Spann, Raimund Helbok, Jose Suarez
Summary: To address the lack of knowledge regarding clinical trial design for patients with disorders of consciousness (DoC), a research group conducted a gap analysis and proposed optimal clinical trial designs for DoC studies.
NEUROCRITICAL CARE
(2023)
Article
Cardiac & Cardiovascular Systems
David X. Zhao, Giorgio Caturegli, Christopher Wilcox, R. Scott Stephens, Bo Soo Kim, Steven Keller, Romergryko G. Geocadin, Jose Suarez, Glenn J. R. Whitman, Sung-Min Cho
Summary: This study retrospectively reviewed a prospective neuromonitoring study conducted in a tertiary care center from June 2016 to March 2022. The aim was to describe the diagnostic criteria and barriers for determining brain death in adult patients on extracorporeal membrane oxygenation (ECMO) support. The results showed that out of eight ECMO patients, six were diagnosed with brain death using the apnea test, while in the other two patients, ancillary tests confirmed the diagnosis due to safety concerns.
