Review
Biochemistry & Molecular Biology
Alexander N. Rodichkin, Tomas R. Guilarte
Summary: Clinical reports on childhood-onset manganese-induced dystonia-parkinsonism have provided valuable insights, but our understanding of the underlying neuropathophysiology remains limited. The availability of Slc39a14 knockout animal models offers a powerful platform for further research into the neurological effects of elevated manganese concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Smrithi Padmakumar, Praveen Kulkarni, Craig F. Ferris, Benjamin S. Bleier, Mansoor M. Amiji
Summary: The clinical translation of therapeutic approaches for treating neurodegenerative conditions such as Parkinson's disease remains a pressing challenge. Recent research has focused on the connection between traumatic brain injury and Parkinson's disease, identifying common targets for the development of more effective treatments. This review provides a detailed background on the pathophysiology of traumatic brain injury and its overlap with Parkinson's disease, with emphasis on their impact on perivascular clearance.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Medicine, General & Internal
Astrid Boucher, Geraldine Brichant, Virginie Gridelet, Michelle Nisolle, Stephanie Ravet, Marie Timmermans, Laurie Henry
Summary: Embryo implantation requires dialogue between embryo and endometrium. Endometriosis affects embryo quality and endometrial receptivity, and the mechanisms underlying its impact are multifactorial and not fully understood.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Thiago Cezar Fujita, Nathalia Sousa-Pereira, Marla Karine Amarante, Maria Angelica Ehara Watanabe
Summary: Acute lymphoid leukemia is a hematological neoplasm that predominantly affects children, with pathophysiology involving chromosomal abnormalities and genetic alterations. While environmental factors are believed to play a role in the development of the disease, there is still conflicting evidence in the literature.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Dentistry, Oral Surgery & Medicine
G. N. Belibasakis, D. Manoil
Summary: Osseointegrated dental implants are a revolutionary tool in reconstructive dentistry for replacing missing teeth and restoring masticatory, occlusal, and esthetic functions. Understanding the microbial communities around dental implants is crucial in developing prevention and treatment strategies for peri-implantitis, as the shift from health to disease involves changes in diversity and the presence of periodontal pathogens.
JOURNAL OF DENTAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Tomasz Iwanowski, Karol Kolkowski, Roman Janusz Nowicki, Malgorzata Sokolowska-Wojdylo
Summary: Vitiligo is a chronic depigmenting disorder of the skin that affects 0.5% to 2% of the world's population. The exact cause of vitiligo is unknown, but several theories have been proposed, including genetic predisposition, oxidative stress, cellular stress, and the impact of T lymphocytes. Recent research has focused on the etiopathogenesis and treatment methods, such as Janus kinase inhibitors, prostaglandins, afamelanotide, Wnt/beta-catenin-signaling agonists, and cell-based therapies. While topical ruxolitinib has been approved for treatment, ongoing clinical trials are investigating the efficacy of oral ritlecitinib, afamelanotide, and latanoprost. Molecular and genetic studies hold promise for the development of highly effective therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Genetics & Heredity
Tiziana Ciarambino, Pietro Crispino, Erika Mastrolorenzo, Antonello Viceconti, Mauro Giordano
Summary: This narrative review aims to improve our understanding of the biological pathways underlying stroke and accelerate the identification of new drug targets. The small effect-size of genetic risk variants poses a challenge for better risk prediction. The use of stroke genetic panels for risk assessment and further research, as well as the discovery of new biomarkers and gene therapy targets, are encouraged.
Article
Clinical Neurology
Ana Rodriguez M. Salgado, Isaac Acosta, Dani J. Kim, Jenny Zitser, Ana Luisa Sosa, Daisy Acosta, Ivonne Z. Jimenez-Velasquez, Mariella Guerra, Aquiles Salas, Adolfo Valvuerdi, Juan C. Llibre-Guerra, Christine Jeyachandran, Ricardo Lopez Contreras, Heike Hesse, Caroline Tanner, JuanJ. Llibre J. Rodriguez, Matthew Prina, Jorge J. Llibre-Guerra
Summary: Neuropsychiatric symptoms (NPSs) are highly prevalent in Hispanic populations with neurodegenerative diseases, particularly in patients with parkinsonism, dementia, and PPD. The most common NPSs include depression, sleep disorders, irritability, and agitation. These symptoms significantly impact caregivers' burden.
ALZHEIMERS & DEMENTIA
(2023)
Review
Medicine, General & Internal
Weronika Domerecka, Anna Kowalska-Kepczynska, Agata Michalak, Iwona Homa-Mlak, Radoslaw Mlak, Halina Cichoz-Lach, Teresa Malecka-Massalska
Summary: Autoimmune hepatitis is a chronic liver disease with an incidence of 10 to 17 per 100,000 people in Europe, mainly affecting individuals in the 40-60 age group. The clinical presentation varies from asymptomatic to severe hepatitis and liver failure, with lifelong treatment aimed at preventing the development of cirrhosis and end-stage liver failure.
Review
Neurosciences
Kuan Zeng, Xuan Yu, Yacoubou Abdoul Razak Mahaman, Jian-Zhi Wang, Rong Liu, Yi Li, Xiaochuan Wang
Summary: Mitophagy disorders play a crucial role in the occurrence and development of Alzheimer's disease, and the interaction with Aβ or Tau pathology may cause neuronal damage and death. Elucidating the molecular mechanism of mitophagy and its role in AD may provide new insights into the etiology and mechanisms.
TRANSLATIONAL NEURODEGENERATION
(2022)
Review
Agriculture, Dairy & Animal Science
Gert W. Niebauer, Brunella Restucci
Summary: The spontaneous rupture of the cranial cruciate ligament in dogs is a common veterinary orthopedic problem. The causes of this disease are largely unknown, making prevention and treatment challenging. Recent research has revealed a systemic, metabolic multifactorial disease background behind the disease, and it also showed an association between this disease in dogs and humans. Therefore, unraveling the enigma of spontaneous cruciate ligament disease is of great importance for the treatment of degenerative joint disease in both dogs and humans.
Review
Biochemistry & Molecular Biology
Michael Gyorfi, Adam Rupp, Alaa Abd-Elsayed
Summary: This article examines the biological, genetic, and environmental factors that may impact the pathogenesis of fibromyalgia. It discusses abnormalities in pain inhibition, changes in sensory input processing, genetics, exposure to stressors, and abnormal reactions in the autonomic nervous system. The article concludes that further research will improve our understanding of the pathophysiology of fibromyalgia and lead to better treatment options for patients.
Review
Biology
Shashank Bhargava, Sara Yumeen, Esther Henebeng, George Kroumpouzos
Summary: Erosive pustular dermatosis (EPD) is a chronic inflammatory skin disorder that mainly affects the scalp and can lead to scarring alopecia. The dysregulated immune response is considered to play a central role in the development of EPD. Current treatment options, such as potent topical steroids and systemic retinoids, show response but recurrence is common. Further controlled studies are needed to provide solid recommendations.
Article
Dentistry, Oral Surgery & Medicine
Evangelia Piperi, Maria Georgaki, Anastasia Andreou, Efstathios Pettas, Styliani Tziveleka, Nikolaos G. Nikitakis
Summary: The etiopathogenesis of CG is likely to be multifactorial, with reduced salivary flow rate and increased viscosity of saliva possibly due to long-term smoking, diabetes mellitus, and drug-induced xerostomia playing a role in the initial pathogenesis, while local irritants may further contribute to the development and aggravation of the condition.
Review
Ophthalmology
Mohammad Javed Ali
Summary: Primary acquired nasolacrimal duct obstruction (PANDO) is a common lacrimal drainage disorder in adults. The current treatment of dacryocystorhinostomy has excellent outcomes, but the understanding of the disease etiopathogenesis needs further study.
PROGRESS IN RETINAL AND EYE RESEARCH
(2023)