Manipulation of the glycan-specific natural antibody repertoire for immunotherapy

Natural and induced B-1 cell immunity to infections raises questions of nature versus nurture

(2015) Nicole Baumgarth et al.   Annals of the New York Academy of Sciences

Characteristics of natural antibody-secreting cells

(2015) Hannah P. Savage et al.   Annals of the New York Academy of Sciences

The Herzenberg lecture: how to make a B-1 cell?

(2015) Klaus Rajewsky   Annals of the New York Academy of Sciences

Natural Antibody Repertoires: Development and Functional Role in Inhibiting Allergic Airway Disease

(2015) John F. Kearney et al.   Annual Review of Immunology

BALB/c and C57BL/6 Mice Differ in Polyreactive IgA Abundance, which Impacts the Generation of Antigen-Specific IgA and Microbiota Diversity

(2015) Floris Fransen et al.   IMMUNITY

Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A

(2015) Jeffrey J. Bunker et al.   IMMUNITY

Lin28b promotes fetal B lymphopoiesis through the transcription factor Arid3a

(2015) Yan Zhou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neonatal Exposure to Pneumococcal Phosphorylcholine Modulates the Development of House Dust Mite Allergy during Adult Life

(2015) Preeyam S. Patel et al.   JOURNAL OF IMMUNOLOGY

Low Levels of IgM Antibodies against an Advanced Glycation Endproduct–Modified Apolipoprotein B100 Peptide Predict Cardiovascular Events in Nondiabetic Subjects

(2015) Daniel Engelbertsen et al.   JOURNAL OF IMMUNOLOGY

Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota

(2015) Cornelia Lindner et al.   NATURE IMMUNOLOGY

Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells

(2015) Wei Shi et al.   NATURE IMMUNOLOGY

An intrinsic mechanism of secreted protein aging and turnover

(2015) Won Ho Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B cell antigen receptors of the IgM and IgD classes are clustered in different protein islands that are altered during B cell activation

(2015) Palash Chandra Maity et al.   Science Signaling

The human IgG anti-carbohydrate repertoire exhibits a universal architecture and contains specificity for microbial attachment sites

(2015) C. Schneider et al.   Science Translational Medicine

Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model

(2015) R. Alhabbab et al.   Scientific Reports

B cell antigen receptors of the IgM and IgD classes are clustered in different protein islands that are altered during B cell activation

(2015) Palash Chandra Maity et al.   Science Signaling

Gut Microbiota Elicits a Protective Immune Response against Malaria Transmission

(2014) Bahtiyar Yilmaz et al.   CELL

B Cells and Humoral Immunity in Atherosclerosis

(2014) Dimitrios Tsiantoulas et al.   CIRCULATION RESEARCH

Xenotransplantation: immunological hurdles and progress toward tolerance

(2014) Adam Griesemer et al.   IMMUNOLOGICAL REVIEWS

Natural IgM: Beneficial Autoantibodies for the Control of Inflammatory and Autoimmune Disease

(2014) Caroline Grönwall et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Ig Knock-In Mice Producing Anti-Carbohydrate Antibodies: Breakthrough of B Cells Producing Low Affinity Anti-Self Antibodies

(2014) L. Benatuil et al.   JOURNAL OF IMMUNOLOGY

Natural IgM Is Produced by CD5−Plasma Cells That Occupy a Distinct Survival Niche in Bone Marrow

(2014) Alexander E. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells

(2014) Giuliana Magri et al.   NATURE IMMUNOLOGY

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

(2014) Y. Goto et al.   SCIENCE

Primary Selective IgM Deficiency: An Ignored Immunodeficiency

(2013) Ankmalika Gupta Louis et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

What Is and What Should Always Have Been: Long-Lived Plasma Cells Induced by T Cell-Independent Antigens

(2013) A. Bortnick et al.   JOURNAL OF IMMUNOLOGY

Secretory IgA Induces Tolerogenic Dendritic Cells through SIGNR1 Dampening Autoimmunity in Mice

(2013) J. Diana et al.   JOURNAL OF IMMUNOLOGY

Microbial colonization influences early B-lineage development in the gut lamina propria

(2013) Duane R. Wesemann et al.   NATURE

Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens

(2013) C. Cywes-Bentley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active and secreted IgA-coated bacterial fractions from the human gut reveal an under-represented microbiota core

(2013) Giuseppe D'Auria et al.   Scientific Reports

Glycobiology of immune responses

(2012) Gabriel A. Rabinovich et al.   Annals of the New York Academy of Sciences

Repertoire of human natural anti-glycan immunoglobulins. Do we have auto-antibodies?

(2012) Nicolai Bovin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

How apoptotic cells aid in the removal of their own cold dead bodies

(2012) G Wickman et al.   CELL DEATH AND DIFFERENTIATION

Engulfment and clearance of apoptotic cells based on a GlcNAc-binding lectin-like property of surface vimentin

(2012) Hirohiko Ise et al.   GLYCOBIOLOGY

B-1 B Cell Development in the Fetus and Adult

(2012) Encarnacion Montecino-Rodriguez et al.   IMMUNITY

Age, microbiota, and T cells shape diverse individual IgA repertoires in the intestine

(2012) Cornelia Lindner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Natural IgM in Immune Equilibrium and Harnessing Their Therapeutic Potential

(2012) S. V. Kaveri et al.   JOURNAL OF IMMUNOLOGY

Natural IgM Anti-Leukocyte Autoantibodies Attenuate Excess Inflammation Mediated by Innate and Adaptive Immune Mechanisms Involving Th-17

(2012) P. I. Lobo et al.   JOURNAL OF IMMUNOLOGY

IgA Response in Preterm Neonates Shows Little Evidence of Antigen-Driven Selection

(2012) T. Rogosch et al.   JOURNAL OF IMMUNOLOGY

Antibodies Generated against Conserved Antigens Expressed by Bacteria and Allergen-Bearing Fungi Suppress Airway Disease

(2012) N. W. Kin et al.   JOURNAL OF IMMUNOLOGY

Reciprocal interactions of the intestinal microbiota and immune system

(2012) Craig L. Maynard et al.   NATURE

MAPK phosphatase-1 is required for regulatory natural autoantibody-mediated inhibition of TLR responses

(2012) C. Gronwall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen-specific memory in B-1a and its relationship to natural immunity

(2012) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen-specific antibody responses in B-1a and their relationship to natural immunity

(2012) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective Roles of Natural IgM Antibodies

(2012) Caroline Grönwall et al.   Frontiers in Immunology

Hygiene Hypothesis and Autoimmune Diseases

(2011) Graham A. W. Rook   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Limiting CDR-H3 Diversity Abrogates the Antibody Response to the Bacterial Polysaccharide   1->3 Dextran

(2011) T. I. Mahmoud et al.   JOURNAL OF IMMUNOLOGY

Long-Term Maintenance of Polysaccharide-Specific Antibodies by IgM-Secreting Cells

(2011) J. B. Foote et al.   JOURNAL OF IMMUNOLOGY

Distinct progenitors for B-1 and B-2 cells are present in adult mouse spleen

(2011) E. E. B. Ghosn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential

(2011) M. Yoshimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of the Mouse B-Cell Repertoirea

(2010) FLAVIUS MARTIN et al.   Annals of the New York Academy of Sciences

A Study on the Glycan Specificity of Natural Antibody Repertoires in Rodents

(2010) Hui Dai et al.   Cellular & Molecular Immunology

Decrease of sialic acid residues as an eat-me signal on the surface of apoptotic lymphocytes

(2010) H. M. Meesmann et al.   JOURNAL OF CELL SCIENCE

The Absence of Serum IgM Enhances the Susceptibility of Mice to Pulmonary Challenge with Cryptococcus neoformans

(2010) K. S. Subramaniam et al.   JOURNAL OF IMMUNOLOGY

Genetically-Defined Deficiency of Mannose-Binding Lectin Is Associated with Protection after Experimental Stroke in Mice and Outcome in Human Stroke

(2010) Alvaro Cervera et al.   PLoS One

The therapeutic potential of targeting B cells and anti-oxLDL antibodies in atherosclerosis

(2009) M. van Leeuwen et al.   AUTOIMMUNITY REVIEWS

Importance of Glycans to the Host-Bacteroides Mutualism in the Mammalian Intestine

(2009) Laurie E. Comstock   Cell Host & Microbe

Low level natural antibodies against phosphorylcholine: A novel risk marker and potential mechanism in atherosclerosis and cardiovascular disease

(2009) Johan Frostegård   CLINICAL IMMUNOLOGY

Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans

(2009) Meng-Yun Chou et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation of B Cell Memory to the Bacterial Polysaccharide  -1,3 Dextran

(2009) J. B. Foote et al.   JOURNAL OF IMMUNOLOGY

Regulation of Dendritic Cells and Macrophages by an Anti-Apoptotic Cell Natural Antibody that Suppresses TLR Responses and Inhibits Inflammatory Arthritis

(2009) Y. Chen et al.   JOURNAL OF IMMUNOLOGY

Terminal Deoxynucleotidyl Transferase Is Required for an Optimal Response to the Polysaccharide  -1,3 Dextran

(2009) T. I. Mahmoud et al.   JOURNAL OF IMMUNOLOGY

Anti-carbohydrate antibodies of normal sera: Findings, surprises and challenges

(2009) Margaret E. Huflejt et al.   MOLECULAR IMMUNOLOGY

Anti-α-glucose–based glycan IgM antibodies predict relapse activity in multiple sclerosis after the first neurological event

(2009) MS Freedman et al.   Multiple Sclerosis Journal

Infections and autoimmunity – friends or foes?

(2009) Shaye Kivity et al.   TRENDS IN IMMUNOLOGY

Pattern recognition receptors in the immune response against dying cells

(2008) Pascale Jeannin et al.   CURRENT OPINION IN IMMUNOLOGY

Irf4 is a positional and functional candidate gene for the control of serum IgM levels in the mouse

(2008) J Côrte-Real et al.   GENES AND IMMUNITY

Dual role for B-1a cells in immunity to influenza virus infection

(2008) Youn Soo Choi et al.   JOURNAL OF EXPERIMENTAL MEDICINE