Article
Biochemistry & Molecular Biology
Marcello Pinti, Lara Gibellini, Domenico Lo Tartaro, Sara De Biasi, Milena Nasi, Rebecca Borella, Lucia Fidanza, Anita Neroni, Leonarda Troiano, Claudio Franceschi, Andrea Cossarizza
Summary: In this study, we analyzed the levels of 62 cytokines and growth factors in healthy centenarians and middle-aged controls. We found an increase in pro-inflammatory cytokines in centenarians, as well as other cytokines involved in inflammation. Anti-inflammatory cytokines did not show an increase, except for the Th2-shifting cytokine IL-19. Several growth factors involved in regulating immunity were also upregulated in centenarians. Principal component analysis showed that pro and anti-inflammatory cytokines contributed the most to the observed data variability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Geriatrics & Gerontology
Wanxue He, Kun Xiao, Min Fang, Lixin Xie
Summary: Sepsis is a life-threatening organ dysfunction caused by dysregulated host responses to infection, with elderly individuals displaying increased susceptibility and mortality due to immune dysfunction. Alterations in immune cells of elderly sepsis patients, including endothelial cells, neutrophils, monocytes, macrophages, natural killer cells, dendritic cells, T lymphocytes, and B lymphocytes, largely contribute to their poor prognosis and increased mortality. Recent studies on elderly mice and sepsis patients have investigated changes affecting both innate and adaptive immune cells, shedding light on potential new therapeutic strategies.
Article
Immunology
Apala Chakraborty, Soumyabrata Banerjee, Biswajit Mukherjee, Mrinal K. Poddar, Nahid Ali
Summary: The study shows that dietary calorie restriction for one and two consecutive months can significantly attenuate aging-related immune system changes, such as decreased lymphocyte viability and increased DNA fragmentation in blood, spleen, and thymus, as well as increased pro-inflammatory cytokines and decreased anti-inflammatory cytokines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Ivon Johanna Rodriguez, Nicolas Lalinde Ruiz, Manuela Llano Leon, Laura Martinez Enriquez, Maria del Pilar Montilla Velasquez, Juan Pablo Ortiz Aguirre, Oscar Mauricio Rodriguez Bohorquez, Esteban Alejandro Velandia Vargas, Edgar Debray Hernandez, Carlos Alberto Parra Lopez
Summary: Aging leads to alterations in immune response, termed immunosenescence, characterized by decreased naive T cells and increased expression of CD57 and KLRG1 in memory T cells in older adults. Proinflammatory cytokines increase and telomere length decrease in old adult T cells. The heterogeneity and biases among studies hinder robust statistical analysis for identifying flow cytometry markers of T cell immunosenescence phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Eric T. Klopack, Eileen M. Crimmins, Steve W. Cole, Teresa E. Seeman, Judith E. Carroll
Summary: Exposure to stress is associated with accelerated immune aging, characterized by a decrease in naive T cells and an increase in terminally differentiated T cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Hoang-Phuong Nguyen, Viet Anh Bui, Ai-Xuan Thi Hoang, Phong Van Nguyen, Dac-Tu Nguyen, Hien Thi Mai, Hai-Anh Le, Thanh-Luan Nguyen, Nhung Thi My Hoang, Liem Thanh Nguyen, Xuan-Hung Nguyen
Summary: This study evaluated the correlation between peripheral blood indices and the expansion of CD8(+) T cells and NK cells in elderly lung cancer patients. CD8(+) T cells and NK cells were able to expand about 500 times from the peripheral blood of these patients. The expansion of these immune cells was inversely correlated with peripheral blood indices. These findings are important for immune therapy in lung cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Davide L. Vetrano, Federico Triolo, Stefania Maggi, Richard Malley, Thomas A. Jackson, Andrea Poscia, Roberto Bernabei, Luigi Ferrucci, Laura Fratiglioni
Summary: The relationship between infections and frailty, as well as the impact of frailty on immune response in older adults, have been studied. Evidence suggests that there is a link between infections and frailty, and frailty may lead to impaired immune response in older ages. However, more research is needed to develop personalized immunization strategies for older adults.
AGEING RESEARCH REVIEWS
(2021)
Review
Immunology
Stephan En Jie Chee, Egle Solito
Summary: Alzheimer's Disease is a progressive neurodegenerative disease associated with aging, characterized by neuroinflammation and amyloid protein accumulation. Research suggests that AD may result from immune system dysregulation due to aging, and future therapies may focus on modulating the aged immune system.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yoo-Jin Bang, So-Hee Hong, Hyo-Jung Park, Hye Won Kwak, Yu-Sun Lee, Jae-Yong Kim, Hyeong-Jun Park, Seo-Hyeon Bae, Hye-Jung Kim, Yun-Hee Kim, Hae Li Ko, Sang-In Park, Hun Kim, Gyeongjoo Park, Man-Seong Park, Jun Chang, Jae-Hwan Nam
Summary: The study demonstrates that single-stranded RNA as an adjuvant can effectively enhance the immune response of aged mice to inactivated influenza vaccine, reducing viral titers and inflammation. Furthermore, ssRNA can induce balanced Th1/Th2 responses and increase IgA levels.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Michael Despeghel, Thomas Reichel, Johannes Zander, Karsten Kruger, Christopher Weyh
Summary: With age, the immune system undergoes remodeling, leading to chronic low-grade inflammation and increased susceptibility to infections. A 6-week low-dose combined resistance and endurance training program showed promising results in reducing immune aging hallmarks and inflammation in older adults.
Article
Medicine, General & Internal
Leah Zuroff, Ayman Rezk, Koji Shinoda, Diego A. Espinoza, Yehezqel Elyahu, Bo Zhang, Andrew A. Chen, Russell T. Shinohara, Dina Jacobs, Roy N. Alcalay, Thomas F. Tropea, Alice Chen-Plotkin, Alon Monsonego, Rui Li, Amit Bar-Or
Summary: In the study comparing untreated MS patients with normal controls, it was found that MS patients exhibited early and persistent redistribution of naive and memory CD4 T-cell compartments. While most CD4 and CD8 T-cell aging trajectories were similar between groups, MS patients demonstrated abnormal age-associated increases, particularly in patients over 60.
Article
Immunology
Rebecca G. Reed, Steven R. Presnell, Ahmad Al-Attar, Charles T. Lutz, Suzanne C. Segerstrom
Summary: Stressful life events can accelerate immune aging, but using cognitive reappraisal as an emotion regulation strategy may reduce these effects. This study investigated whether cognitive reappraisal moderates the relationship between life stressors and immune aging markers in older adults. The results showed that experiencing more frequent life stressors was associated with higher levels of late-differentiated NK cells, but this effect was explained by health-related stressors. Surprisingly, experiencing more frequent and less desirable stressors was associated with lower average levels of TNF-alpha. Moreover, cognitive reappraisal was found to moderate the associations between life stressors and late-differentiated NK cells between individuals and IL-6 within individuals.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Immunology
Shuxian Liao, Qian Ning, Yao Chen, Xuhong Zhao, Shengsong Tang
Summary: Aging is a natural physiological process that increases the risk of chronic diseases in the elderly, and immunosenescence is an important factor. With age, the immune system undergoes changes that result in a decline in resistance to infections, reduced immunity to vaccines, increased incidence of cancer and autoimmune diseases. This review introduces the changes in the immune system, their effects, and anti-aging methods.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mi Eun Kim, Jun Sik Lee
Summary: Aging is associated with weakened immune function and increased susceptibility to diseases. Telomere shortening, tissue inflammation, and altered signaling pathways play key roles in immune dysfunction. Targeting tissue inflammation and immunomodulation is vital for treating immune disorders in older adults. Anti-inflammatory medications, immunotherapy, and novel approaches may enhance immune responses in this population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
P. Spencer Gill, Tammy R. Ozment, Nicole H. Lewis, Edward R. Sherwood, David L. Williams
Summary: Aging and infection severity are closely related, with age as an independent predictor of mortality in sepsis. Trained immunity can improve immune function in aging and/or sepsis patients, but there is limited data on trained immunity in the aging immune system or in the presence of sepsis. This study found that trained immunity can be induced in aging monocytes and monocytes from sepsis patients, resulting in enhanced metabolic capacity and cytokine production.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Fatima de Lourdes Ochoa-Gonzalez, Yadira Bastian, Valeria Rivera-Carrera, Ivan Alejandro Garcia-Tiscareno, Martin Zapata-Zuniga, Jesus Adrian Lopez, J. Alfredo Mendez, Jose Antonio Enciso-Moreno, Julio Enrique Castaneda-Delgado
Summary: This study investigated the role of protease inhibitors in neutrophil extracellular trap (NET) formation, with a focus on the involvement of calpain in DNA release. The findings suggest that actin remodeling plays a crucial role in NET formation, and that calpain modulates actin cytoskeleton reorganization and DNA release in a calcium-dependent manner.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Elsy Janeth Ramos-Gonzalez, Yadira Bastian, Julio Enrique Castaneda-Delgado, Martin Zapata-Zuniga, Mariela Gomez-Moreno, Jose Dionisio Castillo-Ortiz, Cesar Ramos-Remus, Jose Antonio Enciso-Moreno
Summary: The study found that the expression levels of TLR7 and TLR9 are elevated in the early stage of rheumatoid arthritis (RA), and may be associated with the production of autoantibodies, suggesting a role of TLR7 in the development of autoantibodies.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jovany Almaraz-De-Santiago, Nancy Solis-Torres, Raul Quintana-Belmares, Adrian Rodriguez-Carlos, Bruno Rivas-Santiago, Josefina Huerta-Garcia, Marisa Mercado-Reyes, Jose A. Enciso-Moreno, Julio Villagomez-Castro, Irma Gonzalez-Curiel, Alvaro Osornio-Vargas, Cesar E. Rivas-Santiago
Summary: Epidemiological studies have shown that long-term exposure to environmental air pollution particulate matter is associated with the development of respiratory inflammation and may increase the risk of microbial colonization and diseases.
Article
Biochemistry & Molecular Biology
Nazly Z. Duran-Saenz, Alejandra Serrano-Puente, Perla Gallegos-Flores, Brenda D. Mendoza-Almanza, Edgar L. Esparza-Ibarra, Susana Godina-Gonzalez, Irma E. Gonzalez-Curiel, Jorge L. Ayala-Lujan, Marisa Hernandez-Barrales, Cecilia F. Cueto-Villalobos, Sharahy Y. Frausto-Fierros, Luis A. Burciaga-Hernandez, Gretel Mendoza-Almanza
Summary: Cell membranes not only act as biological barriers, but also serve as contact structures between the interior and exterior of cells. In the context of cancer, cancer cells must adapt to the tumor microenvironment and acquire the ability to change their shape through the cell membrane. Additionally, platelets play an important role in the tumor microenvironment and the metastatic process.
Article
Biochemistry & Molecular Biology
Andrea Olmos-Ortiz, Mayra Hernandez-Perez, Pilar Flores-Espinosa, Gabriela Sedano, Addy Cecilia Helguera-Repetto, Oscar Villavicencio-Carrisoza, Maria Yolotzin Valdespino-Vazquez, Arturo Flores-Pliego, Claudine Irles, Bruno Rivas-Santiago, Elsa Romelia Moreno-Verduzco, Lorenza Diaz, Veronica Zaga-Clavellina
Summary: Infectious processes in the uterine cavity can compromise the maternal-fetal unit and increase the risk of preterm birth and premature rupture of membranes. This study aimed to characterize the synthesis, activity, and distribution of antimicrobial peptides (AMPs) produced by fetal membranes in response to a choriodecidual Escherichia coli infection. The results showed a temporal- and tissue-specific pattern of AMP synthesis, but the membranes were unable to contain bacterial growth and migration despite the production of AMPs, increasing the risk of preterm birth and premature rupture of membranes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
M. A. Valtierra-Alvarado, J. E. Castaneda-Delgado, G. Lugo-Villarino, F. Duenas-Arteaga, B. Rivas-Santiago, J. A. Enciso-Moreno, C. J. Serrano
Summary: This study evaluated the frequency of CD14+HLA-DR-/low cells in non-obese T2DM patients and their association with glycemic control. The results showed an increased frequency of these cells in T2DM patients, which was correlated with poor glycemic control, years since the diagnosis of T2DM, and age.
Article
Microbiology
Gwendolyne Mendez-Frausto, Susana Godina-Gonzalez, Cesar E. Rivas-Santiago, Edna Nungaray-Anguiano, Gretel Mendoza-Almanza, Bruno Rivas-Santiago, Carlos E. Galvan-Tejada, Irma E. Gonzalez-Curiel
Summary: The aim of this study was to analyze molecules associated with regulatory immune response in unvaccinated, recovered COVID-19 patients with and without diabetes mellitus (DM) and hypertension (HTN). The study found that patients with comorbidities produced more antibodies compared to non-comorbid patients. The level of co-stimulatory inhibitory molecule sCTLA-4 was higher in the non-comorbid group, and the level of IL-10 increased in seropositive subjects without comorbidities. In conclusion, comorbidities affect the immune response of patients recovering from mild COVID-19.
Article
Environmental Sciences
Oliver Mendoza-Cano, Efren Murillo-Zamora, Angeles Catalina Ochoa-Martinez, Valeria Argentina Mendoza-Olivo, Monica Rios-Silva, Xochitl Trujillo, Miguel Huerta, Jaime Alberto Bricio-Barrios, Veronica Benites-Godinez, Irma Gonzalez-Curiel, Rebeca Yasmin Perez-Rodriguez, Nadia Azenet Pelallo-Martinez, Agustin Lugo-Radillo
Summary: This study reports on the burden of respiratory malignant tumors (tracheal, bronchial, and lung) in Mexico and finds a linear relationship between this burden and the proportion of daily smokers and total lead emissions.
Article
Biochemistry & Molecular Biology
Luis A. Burciaga-Hernandez, Cecilia F. Cueto-Villalobos, Nancy Ortega-Pinon, Irma E. Gonzalez-Curiel, Susana Godina-Gonzalez, Gwendolyne Mendez-Frausto, Anna P. Aguilar-Esquivel, Vilma Maldonado-Lagunas, Luis E. de la Torre, Jorge Melendez-Zajgla, Erika K. Sanchez-Garcia, Irma B. Mitre-Aguilar, Gretel Mendoza-Almanza
Summary: The tumor microenvironment (TME) consists of various cell populations that contribute to the regulation of cellular activities within the TME, including angiogenesis and metastasis. Platelets in the TME can be converted into tumor-educated platelets (TEP), which support the development of cancer through the release of biomolecules. This study aimed to analyze the expression levels of specific genes related to breast cancer progression, angiogenesis, and metastasis in tumor tissues and platelets from breast cancer patients. The results showed that there is a correlation in the expression levels of these genes between platelets and breast cancer tumors, depending on the molecular subtype, comorbidities, and metastasis presence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Pamela Gallegos-Alcala, Mariela Jimenez, Daniel Cervantes-Garcia, Laura Elena Cordova-Davalos, Irma Gonzalez-Curiel, Eva Salinas
Summary: In this study, it was found that glycomacropeptide (GMP) has anti-inflammatory and antioxidative properties on HaCaT keratinocytes in an in vitro model of atopic dermatitis. Furthermore, GMP stimulated cell proliferation and migration, suggesting its potential therapeutic use in wound healing.
Article
Immunology
Bruno Rivas-Santiago, Jeny de Haro-Acosta, Adrian Rodriguez Carlos, Mariana H. Garcia-Hernandez, Carmen J. Serrano, Irma Gonzalez-Curiel, Cesar Rivas-Santiago
Summary: Nicotine promotes the growth of Mycobacterium tuberculosis and increases the expression of virulence-related genes, which may be associated with an increased risk of smokers developing tuberculosis.
MICROBIOLOGY AND IMMUNOLOGY
(2023)
Article
Oncology
Oscar Antonio Ortega-Rivera, Pamela Gallegos-Alcala, Mariela Jimenez, J. Luis Quintanar, Flor Torres-Juarez, Bruno Rivas-Santiago, Susana del Toro-Arreola, Eva Salinas
Summary: In this study, the antitumor activity of recombinant Newcastle disease virus (rNDV-P05) was evaluated in a breast cancer murine model. The results demonstrated that systemic administration of the virus significantly reduced tumor mass and volume, inhibited the formation of metastatic clonogenic colonies in lung tissue, and increased the inhibition rate of the tumor. This antitumor and antimetastatic effect was mediated through the immune-stimulatory effect of the virus, which upregulated tumor necrosis factor and related apoptosis-inducing ligand expression, recruited CD8+ T cells into tumor tissue, and increased interferon levels.
JOURNAL OF BREAST CANCER
(2023)
Article
Biochemistry & Molecular Biology
Erika Maldonado-Rodriguez, Marisa Hernandez-Barrales, Adrian Reyes-Lopez, Susana Godina-Gonzalez, Perla Gallegos-Flores, Edgar L. Esparza-Ibarra, Irma E. Gonzalez-Curiel, Jesus Aguayo-Rojas, Adrian Lopez-Saucedo, Gretel Mendoza-Almanza, Jorge L. Ayala-Lujan
Summary: Breast cancer is a leading cause of cancer death among women worldwide. The presence of HPV DNA in malignant breast tumors has been reported by various research groups, although its role in mammary carcinogenesis is not fully understood. This study aimed to detect HPV DNA in breast tissue biopsies and classify them according to histology. The results showed that HPV DNA was present in both malignant and non-malignant breast disease, with a higher frequency in the non-malignant group.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Julio Enrique Castaneda-Delgado, Noe Macias-Segura, Cesar Ramos-Remus
Summary: Recent advances in gene expression analysis techniques have provided a deeper understanding of the complexity of inflammatory responses, including rheumatic diseases like rheumatoid arthritis (RA). The coincidence in genetic and epigenetic regulatory events leading to RA's inflammatory state has been recognized. Researchers have identified specific miRNAs that are abundant in early stages of RA and are associated with treatment responses. The discovery of RNA-based biomarkers has great potential for clinical application, including disease detection, follow-up, treatment targets, and monitoring treatment responses, especially in the context of the COVID-19 pandemic.
