Journal
IMMUNOLOGIC RESEARCH
Volume 64, Issue 4, Pages 931-939Publisher
HUMANA PRESS INC
DOI: 10.1007/s12026-016-8789-7
Keywords
Curdlan; Myeloid-derived suppressor cells; Immune suppression; Anti-tumor immunity
Categories
Funding
- Specialized Project for Clinical Medicine of Jiangsu Province [BL2014065]
- Natural Science Foundation of Jiangsu [BK20150533]
- National Natural Science Foundation of China [31170849, 31470881]
- Science and Technology Support Program (Social Development) of Zhenjiang [SH2014039, SH2014042]
- Jiangsu Province 333 Project [BRA2015197]
- Summit of the Six Top Talents Program of Jiangsu Province [2015-WSN-116]
- Jiangsu University Science Foundation [15JDG070, 11JDG093, FCJJ2015022]
- Graduate Student Research and Innovation Program of Jiangsu Province [KYLX_1074]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Ask authors/readers for more resources
Tumor-elicited immunosuppression is one of the essential mechanisms for tumor evasion of immune surveillance. It is widely thought to be one of the main reasons for the failure of tumor immunotherapy. Myeloid-derived suppressor cells (MDSCs) comprise a heterogeneous population of cells that play an important role in tumor-induced immunosuppression. These cells expand in tumor-bearing individuals and suppress T cell responses via various mechanisms. Curdlan, the linear (1 -> 3)-beta-glucan from Agrobacterium, has been applied in the food industry and other sectors. The anti-tumor property of curdlan has been recognized for a long time although the underlying mechanism still needs to be explored. In this study, we investigated the effect of curdlan on MDSCs and found that curdlan could promote MDSCs to differentiate into a more mature state and then significantly reduce the suppressive function of MDSCs, decrease the MDSCs in vivo and down-regulate the suppression in tumor-bearing mice, thus leading to enhanced anti-tumor immune responses. We, therefore, increase the understanding of further mechanisms by which curdlan achieves anti-tumor effects.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available