Article
Medicine, Research & Experimental
Tiphaine Parrot, Katie Healy, Caroline Boulouis, Michal J. Sobkowiak, Edwin Leeansyah, Soo Aleman, Antonio Bertoletti, Margaret Sallberg Chen, Johan K. Sandberg
Summary: The progress in understanding MR1-restricted MAIT cells has led to interest in using them for immunotherapy. The established method for MAIT cell expansion preserves their functional response and increases their cytotoxic potential, while also enhancing tissue tropism and effector memory characteristics.
Article
Biochemistry & Molecular Biology
Emmelie Eckhardt, Max Bastian
Summary: The CD1 antigen presenting system is evolutionarily conserved and can be found in mammals, birds, and reptiles. Research on the role of CD1a, CD1b, and CD1c in mice has been hindered by their lack of expression in mice, but alternative animal models have provided valuable insights into CD1-dependent antimicrobial immune functions. Transgenic mouse models have also contributed to a better understanding of the mechanisms involved in CD1-restricted T cell responses.
MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Shogo Soma, Deborah A. Lewinsohn, David M. Lewinsohn
Summary: DURTs, characterized by invariant antigen presentation molecules, can recognize diverse mycobacterial antigens, potentially serving as vaccination targets or enabling traditional immune responses.
Article
Medicine, General & Internal
Anele Gela, Melissa Murphy, Miguel Rodo, Kate Hadley, Willem A. Hanekom, W. Henry Boom, John L. Johnson, Daniel F. Hoft, Simone A. Joosten, Tom H. M. Ottenhoff, Sara Suliman, D. Branch Moody, David M. Lewinsohn, Mark Hatherill, Chetan Seshadri, Elisa Nemes, Thomas J. Scriba, Libby Briel, Hellen Veldtsman, Nondumiso Khomba, Bernadette Pienaar, Hadn Africa, Marcia Steyn
Summary: DURT cells, which have nearly unrestricted antigen recognition, play an important role in tuberculosis vaccine development. This study investigated the roles of DURT cells in BCG vaccination and found that BCG did not modulate most DURT cell populations.
Review
Immunology
Paula Ruibal, Linda Voogd, Simone A. Joosten, Tom H. M. Ottenhoff
Summary: DURTs can respond to the same ligands across diverse human populations, which can be activated through TCR ligation or bystander cytokine signaling. NK cells and innate lymphoid cells lack rearranged TCRs and can be activated through other pathways or bystander cytokines.
IMMUNOLOGICAL REVIEWS
(2021)
Article
Multidisciplinary Sciences
Michela Consonni, Claudio Garavaglia, Andrea Grilli, Claudia de Lalla, Alessandra Mancino, Lucia Mori, Gennaro De Libero, Daniela Montagna, Monica Casucci, Marta Serafini, Chiara Bonini, Daniel Haussinger, Fabio Ciceri, Massimo Bernardi, Sara Mastaglio, Silvio Bicciato, Paolo Dellabona, Giulia Casorati
Summary: The study demonstrates that engineered human T cells can effectively target leukemia cells expressing CD1c through a specific mLPA-TCR, delaying leukemia progression in mouse models. This approach has the potential to overcome MHC barriers between different donors and recipients, reducing the risk of graft-versus-host disease.
NATURE COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Jeffrey Y. W. Mak, Ligong Liu, David P. Fairlie
Summary: Researchers have made significant contributions in the field of microbial natural products and synthetic ligands over the past decade, particularly focusing on compounds related to riboflavin and uracils that modulate immune cells. Through collaboration, they discovered a naturally occurring compound synthesized by bacteria that activates MAIT cells, leading to its use in detecting and characterizing MAIT cells in tissues.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Immunology
Spencer E. E. Brightman, Angelica Becker, Rukman R. R. Thota, Martin S. S. Naradikian, Leila Chihab, Karla Soria Zavala, Ryan Q. Q. Griswold, Joseph S. S. Dolina, Ezra E. W. Cohen, Aaron M. M. Miller, Bjoern Peters, Stephen P. P. Schoenberger
Summary: CD4(+) T cells have important roles in immune responses, either directly or through accessory cells such as CD8(+) T lymphocytes. While the role of NeoAg-specific CD8(+) T cells in cancer has been extensively studied, the role of NeoAg-specific CD4(+) T cells is less well understood.
Review
Dermatology
Samantha Genardi, Eva Morgun, Chyung-Ru Wang
Summary: This review discusses the role of CD1-restricted T cells in autoimmune skin conditions, including their recognition of self-lipids and aberrant regulation mechanisms.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Immunology
Adam Shahine, Ildiko Van Rhijn, Jamie Rossjohn, D. Branch Moody
Summary: Studies show that autoreactive αβ T-cell receptors can directly recognize the outer surface of CD1 proteins in a lipid-agnostic manner, which is contrary to the previous understanding of lipid antigens activating CD1-restricted T cells. Recently, natural CD1 ligands have been discovered that dominantly negatively block autoreactive αβ T-cell receptor binding to CD1a and CD1d. This review highlights the differences between positive and negative regulation of cellular systems and outlines strategies to discover lipid inhibitors of CD1-reactive T cells, especially in CD1-mediated skin disease.
CURRENT OPINION IN IMMUNOLOGY
(2023)
Article
Immunology
Tina De Bruyn Carlier, Fariza Mishaal Saiema Badloe, Johannes Ring, Jan Gutermuth, Inge Kortekaas Krohn
Summary: Atopic dermatitis is a chronic inflammatory skin disease that develops in early childhood and is associated with food allergy, with immune reactions potentially leading to autoimmune processes. The exact mechanisms of IgE-mediated autoimmunity and self-reactive T cells in the pathophysiology of AD are still unclear.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Microbiology
Anna Furuta, Michelle Coleman, Raquel Casares, Ravin Seepersaud, Austyn Orvis, Alyssa Brokaw, Phoenicia Quach, Shayla Nguyen, Erin Sweeney, Kavita Sharma, Grace Wallen, Rhea Sanghavi, Jaime Mateos-Gil, Juan Manuel Cuerva, Alba Millan, Lakshmi Rajagopal
Summary: By investigating the R-P4 compound, a non-toxic analog of the GBS lipid toxin, it was discovered that immunizing mice with this compound could promote opsonophagocytic killing of the bacteria and protect the mice from GBS infection. CD4(+) T cells from R-P4-immunized mice showed increased proliferation in response to R-P4 stimulation, and this immune response was CD1d- and iNKT cell-dependent. Transferring iNKT cells from R-P4-vaccinated mice to other mice significantly reduced GBS dissemination, and maternal R-P4 vaccination provided protection against ascending GBS infection during pregnancy.
Review
Biochemistry & Molecular Biology
Hyun Jung Yoo, Na Young Kim, Ji Hyung Kim
Summary: CD1a is a family of cell-surface glycoproteins that present lipid antigens to T cells. CD1a-restricted T cells can interact with the CD1a:lipid complex in various ways, potentially contributing to inflammatory skin disorders and other diseases.
MOLECULES AND CELLS
(2021)
Article
Immunology
Brendan W. MacNabb, Sravya Tumuluru, Xiufen Chen, James Godfrey, Darshan N. Kasal, Jovian Yu, Marlieke L. M. Jongsma, Robbert M. Spaapen, Douglas E. Kline, Justin Kline
Summary: This study demonstrates the importance of MHC-I cross-dressing in regulating anti-tumor immunity. In addition to quantitatively enhancing tumor antigen presentation, it also enables dendritic cells to more accurately mirror the cancer cell peptidome.
Article
Immunology
Nicholas A. Gherardin, Samuel J. Redmond, Hamish E. G. McWilliam, Catarina F. Almeida, Katherine H. A. Gourley, Rebecca Seneviratna, Shihan Li, Robert De Rose, Fiona J. Ross, Catriona Nguyen-Robertson, Shian Su, Matthew E. Ritchie, Jose A. Villadangos, D. Branch Moody, Daniel G. Pellicci, Adam P. Uldrich, Dale Godfrey
Summary: This study identified members of the CD36 family as ligands for CD1c, CD1b, and CD1d proteins, with CD36 being responsible for non-TCR-mediated CD1c tetramer staining of blood cells. Blocking CD36 clarified the identification of CD1c-restricted T cells and enhanced the detection of CD1b- and CD1d-restricted T cells. The technique developed in this study allowed for the characterization of diverse phenotypic features, TCR repertoire, and antigen-specific subsets of CD1c-restricted T cells, facilitating further research in the biology of CD1 and human CD1-restricted T cells.
SCIENCE IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Ildiko Van Rhijn, Twan van Berlo, Tamara Hilmenyuk, Tan-Yun Cheng, Benjamin J. Wolf, Raju V. V. Tatituri, Adam P. Uldrich, Giorgio Napolitani, Vincenzo Cerundolo, John D. Altman, Peter Willemsen, Shouxiong Huang, Jamie Rossjohn, Gurdyal S. Besra, Michael B. Brenner, Dale I. Godfrey, D. Branch Moody
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Review
Immunology
Shouxiong Huang
FRONTIERS IN IMMUNOLOGY
(2016)
Article
Oncology
Scott Langevin, Damaris Kuhnell, Tess Parry, Jacek Biesiada, Shouxiong Huang, Trisha Wise-Draper, Keith Casper, Xiang Zhang, Mario Medvedovic, Susan Kasper
Article
Multidisciplinary Sciences
Manju Sharma, Xiang Zhang, Shuangmin Zhang, Liang Niu, Shuk-mei Ho, Aimin Chen, Shouxiong Huang
SCIENTIFIC REPORTS
(2017)
Article
Immunology
Dalam Ly, Anne G. Kasmar, Tan-Yun Cheng, Annemieke de Jong, Shouxiong Huang, Sobhan Roy, Apoorva Bhatt, Ruben P. van Summeren, John D. Altman, William R. Jacobs, Erin J. Adams, Adriaan J. Minnaard, Steven A. Porcelli, Branch Moody
JOURNAL OF EXPERIMENTAL MEDICINE
(2013)
Article
Immunology
Annemieke de Jong, Tan-Yun Cheng, Shouxiong Huang, Stephanie Gras, Richard W. Birkinshaw, Anne G. Kasmar, Ildiko Van Rhijn, Victor Pena-Cruz, Daniel T. Ruan, John D. Altman, Jamie Rossjohn, D. Branch Moody
Article
Multidisciplinary Sciences
Yunan Wang, Abudurexiti Kayoumu, Guotao Lu, Pengfei Xu, Xu Qiu, Liye Chen, Rong Qi, Shouxiong Huang, Weiqin Li, Yuhui Wang, George Liu
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Manju Sharma, Xiang Zhang, Shouxiong Huang
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2018)
Article
Immunology
Manju Sharma, Shuangmin Zhang, Liang Niu, David M. Lewinsohn, Xiang Zhang, Shouxiong Huang
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Environmental Sciences
Yinyin Zhang, Wenya Shao, Jingwen Wu, Shouxiong Huang, Hongyu Yang, Zhousong Luo, Fuli Zheng, Yuan-Liang Wang, Ping Cai, Zhenkun Guo, Siying Wu, Huangyuan Li
Summary: This study revealed that inflammatory lncRNA AK039862 plays a crucial role in the complex communication between microglia and dopaminergic cells in the presence of PQ-induced neuroinflammatory damage. AK039862 contributed to the neuronal injury process in PQ-treated mice and co-localized with dopaminergic cells in vivo. Furthermore, PQ significantly inhibited microglia and dopaminergic cells proliferation and microglia migration in vitro. The low expression of AK039862 induced by PQ was found to rescue microglia proliferation and migration inhibition via the AK039862/Pafah1b1/Foxa1 pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Immunology
Fangfang Bai, Zi Chen, Shuanglan Xu, Lu Han, Xiaoning Zeng, Shouxiong Huang, Zhou Zhu, Linfu Zhou
Summary: The study found that wogonin alleviates airway neutrophilia in severe neutrophilic asthma by inducing neutrophil apoptosis and inhibiting HMGB1-mediated ASMCs activation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Manju Sharma, Liang Niu, Xiang Zhang, Shouxiong Huang
Summary: A study found that Mucosal-Associated Invariant T (MAIT) cells provide protection against tuberculous and non-tuberculous mycobacterial infections, but the mechanisms are poorly understood. Comparing the responses of MAIT cells to E. coli and Bacillus Calmette-Guerin (BCG) stimulation, it was observed that BCG induced greater changes in MAIT cell genes, enhancing their survival and cytotoxic capabilities. Therefore, this study suggests that BCG induces cell-mediated effector responses in MAIT cells to combat mycobacterial infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shouxiong Huang, Adam Shahine, Tan-Yun Cheng, Yi-Ling Chen, Soo Weei Ng, Gautham R. Balaji, Rachel Farquhar, Stephanie Gras, Clare S. Hardman, John D. Altman, Nabil Tahiri, Adriaan J. Minnaard, Graham S. Ogg, Jacob A. Mayfield, Jamie Rossjohn, D. Branch Moody
Summary: The study identified the lipid profiles of four human CD1 antigen-presenting molecules, revealing a broad presentation of self-sphingolipids and phospholipids. Each type of CD1 protein displayed distinct capture motifs based on lipid length and chemical composition.
Review
Medicine, General & Internal
Shouxiong Huang, Quan He, Linfu Zhou
Summary: This article critically reviews the activation, effector, and regulation of T cells in respiratory viral infections and chronic inflammations associated with COPD, highlighting the importance of crosstalk among T cells, innate immune cells, and airway epithelial cells in the pathogenesis of viral infections and COPD. It emphasizes the specificity of peptide antigens and the functional heterogeneity of conventional CD4(+) and CD8(+) T cells as potential targets for future development of therapeutics against respiratory viral infections and inflammations.
CHINESE MEDICAL JOURNAL
(2021)
