Journal
IMMUNOGENETICS
Volume 68, Issue 9, Pages 743-747Publisher
SPRINGER
DOI: 10.1007/s00251-016-0924-z
Keywords
LILR; Atopic dermatitis; AD; CNV
Categories
Funding
- Medical Research Council (MRC)
- Association for International Cancer Research (AICR)
- Wellcome Trust
- National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre
- Ministerio de Educacion of Spain, under the programme Programa Nacional de Movilidad de Recursos Humanos del Plan Nacional de I-D+i
- Fundacion Seneca Project [04087/GERM/06]
- Worldwide Cancer Research [13-0074] Funding Source: researchfish
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Leukocyte immunoglobulin-like receptors (LILR) are expressed mostly on myelomonocytic cells where they are mediators of immunological tolerance. Two LILR genes, LILRA3 and LILRA6, exhibit marked copy number variation. We assessed the contribution of these genes to atopic dermatitis (AD) by analysing transmission in 378 AD families. The data indicated that copies of LILRA6 were over-transmitted to affected patients. They are consistent with a contribution of LILR genes to AD. They could affect the equilibrium between activating and inhibitory signals in the immune response.
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