Involvement of endoplasmic reticulum stress in rotenone-induced leber hereditary optic neuropathy model and the discovery of new therapeutic agents

Rotenone-induced inner retinal degeneration via presynaptic activation of voltage-dependent sodium and L-type calcium channels in rats

(2020) Masaaki Sasaoka et al.   Scientific Reports

Glutamate Stimulation Dysregulates AMPA Receptors-Induced Signal Transduction Pathway in Leber’s Inherited Optic Neuropathy Patient-Specific hiPSC-Derived Retinal Ganglion Cells

(2019) Yang et al.   Cells

Current and Emerging Treatment Modalities for Leber’s Hereditary Optic Neuropathy: A Review of the Literature

(2018) Anna Theodorou-Kanakari et al.   ADVANCES IN THERAPY

Neuroprotective Effect of Ocular Hypotensive Drugs: Latanoprost/Timolol in Combination Are More Effective than Each as Monotherapy in RGC-5

(2016) Shinichiro Fuma et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The metabolomic signature of Leber’s hereditary optic neuropathy reveals endoplasmic reticulum stress

(2016) Juan Manuel Chao de la Barca et al.   BRAIN

Border between natural product and drug: Comparison of the related benzoquinones idebenone and coenzyme Q10

(2015) Nuri Gueven et al.   Redox Biology

Cell therapy using retinal progenitor cells shows therapeutic effect in a chemically-induced rotenone mouse model of Leber hereditary optic neuropathy

(2014) Fiona C Mansergh et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

White Matter Consequences of Retinal Receptor and Ganglion Cell Damage

(2014) S. Ogawa et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Profiling the Mitochondrial Proteome of Leber’s Hereditary Optic Neuropathy (LHON) in Thailand: Down-Regulation of Bioenergetics and Mitochondrial Protein Quality Control Pathways in Fibroblasts with the 11778G>A Mutation

(2014) Aung Win Tun et al.   PLoS One

Idebenone Protects against Retinal Damage and Loss of Vision in a Mouse Model of Leber’s Hereditary Optic Neuropathy

(2012) Fabrice D. Heitz et al.   PLoS One

NQO1-Dependent Redox Cycling of Idebenone: Effects on Cellular Redox Potential and Energy Levels

(2011) Roman H. Haefeli et al.   PLoS One

An Inducer of VGF Protects Cells against ER Stress-Induced Cell Death and Prolongs Survival in the Mutant SOD1 Animal Models of Familial ALS

(2010) Masamitsu Shimazawa et al.   PLoS One

Edaravone, a Free Radical Scavenger, Protects against Retinal Damage in Vitro and in Vivo

(2009) Y. Inokuchi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Redox survival signalling in retina-derived 661W cells

(2008) A M Mackey et al.   CELL DEATH AND DIFFERENTIATION