Comparison of LC–MS3 and LC–MRM strategy for quantification of methotrexate in human plasma and its application in therapeutic drug monitoring

Sensitive determination of methotrexate in plasma of children with acute leukemia using double-solvent supramolecular systemas a novel extractant for dispersive liquid-liquid microextraction

(2021) Reza Akramipour et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

A Review of Clinical Applications and Side Effects of Methotrexate in Ophthalmology

(2020) Ge Wang et al.   Journal of Ophthalmology

Simultaneous Determination of Urine Methotrexate, 7-Hydroxy Methotrexate, Deoxyaminopteroic Acid, and 7-Hydroxy Deoxyaminopteroic Acid by UHPLC-MS/MS in Patients Receiving High-dose Methotrexate Therapy

(2020) Shenghui MEI et al.   ANALYTICAL SCIENCES

Simultaneous Quantification of Methotrexate and Its Metabolite 7-Hydroxy-Methotrexate in Human Plasma for Therapeutic Drug Monitoring

(2019) Xinxin Ren et al.   International Journal of Analytical Chemistry

Bioanalytical method validation of endogenous substances according to guidelines by the FDA and other organizations: Basic need to specify concentration ranges

(2018) Dimitrios Tsikas   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Bioanalytical method validation: new FDA guidance vs. EMA guideline. Better or worse?

(2018) Michał Kaza et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Highly sensitive LC–MS/MS methods for urinary biological monitoring of occupational exposure to cyclophosphamide, ifosfamide, and methotrexate antineoplastic drugs and routine application

(2016) Mireille Canal-Raffin et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Development and validation of LC–MS/MS assay for the simultaneous determination of methotrexate, 6-mercaptopurine and its active metabolite 6-thioguanine in plasma of children with acute lymphoblastic leukemia: Correlation with genetic polymorphism

(2016) Medhat A. Al-Ghobashy et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

A simple, rapid and reliable liquid chromatography-mass spectrometry method for determination of methotrexate in human plasma and its application to therapeutic drug monitoring

(2015) Dan Wu et al.   BIOMEDICAL CHROMATOGRAPHY

Common bioanalytical deficiencies with bioequivalence submissions in Abbreviated New Drug Applications

(2014) Leah N Williamson et al.   Bioanalysis

Simple and Reliable HPLC Method for the Monitoring of Methotrexate in Osteosarcoma Patients

(2013) E. Begas et al.   JOURNAL OF CHROMATOGRAPHIC SCIENCE

A validated LC–MS/MS method for rapid determination of methotrexate in human saliva and its application to an excretion evaluation study

(2013) Igor Rodin et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

A novel high-performance liquid chromatography/mass spectrometry method for improved selective and sensitive measurement of methotrexate polyglutamation status in human red blood cells

(2009) Leon van Haandel et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY