Article
Allergy
Emily Howard, Gavin Lewis, Lauriane Galle-Treger, Benjamin P. Hurrell, Doumet Georges Helou, Pedram Shafiei-Jahani, Jacob D. Painter, German Aleman Muench, Pejman Soroosh, Omid Akbari
Summary: The study identified a unique subset of ILC2s, known as ILC2(10)s, which actively produce IL-10 to suppress proinflammatory ILC2 functions through autocrine and paracrine signaling, resulting in reduced lung inflammation and airway hyperresponsiveness in vivo. Furthermore, the research highlights the metabolic dependency of ILC2(10)s on the glycolytic pathway for IL-10 production, contrasting with the conventional fatty acid oxidation pathway used for proinflammatory effector functions.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Microbiology
Fuchun Zhang, Lingling Sun, Mark K. Lafferty, Joseph B. Margolick, Alfredo Garzino-Demo
Summary: HIV infection leads to the inhibition of CCR6 chemokine MIP-3 alpha, resulting in the loss of immune function and the progression of AIDS.
Article
Dermatology
Kristin Knoke, Robert R. Rongisch, Katarzyna M. Grzes, Roman Schwarz, Beate Lorenz, Nir Yogev, Erika L. Pearce, Edward J. Pearce, David M. Kofler, Mario Fabri
Summary: This study investigates the effects of Jak inhibitors, specifically tofacitinib, on the host defense responses in toll-like receptor 4-activated macrophages. The findings suggest that tofacitinib blocks macrophage responses to IL-10 and regulates iron metabolism. The study also identifies the toll-like receptor 4-IL-10-signal transducer and activator of transcription 3-HAMP axis as a potential therapeutic target to counteract immune evasion.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Food Science & Technology
Jieping Yang, Rupo Lee, Susanne M. Henning, Emily Xing, Jianjun Huang, Scarlet Yang, Michael C. Garcia, Vijaya Surampudi, David Heber, Zhaoping Li
Summary: This study investigates the mechanisms of cholesterol reduction by evaluating biomarkers of cholesterol synthesis, intestinal absorption, and miRNA involved in transcriptional regulation, as well as cholesterol oxidation.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Immunology
Gunjan Kak, Zachary Van Roy, Cortney E. E. Heim, Rachel W. W. Fallet, Wen Shi, Axel Roers, Bin Duan, Tammy Kielian
Summary: The study found that IL-10 derived from granulocytes plays a role in suppressing the clearance of Staphylococcus aureus during craniotomy infection, possibly by inhibiting neutrophil bactericidal activity and TNF production.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Roberto Riquelme-Neira, Romina Walker-Vergara, Joan Antoni Fernandez-Blanco, Patrocinio Vergara
Summary: Mast cells play important roles in various immune-related responses, and IL-10 is involved in modulating their activation. However, the precise mechanism of IL-10 in PRR-mediated activation of mast cells remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Stephen T. Yeung, Luis J. Ovando, Ashley J. Russo, Vijay A. Rathinam, Kamal M. Khanna
Summary: Macrophages play important roles in regulating pathogen clearance and immune homeosta-sis in tissues. The functional diversity of macrophage subsets depends on tissue environment and the nature of the pathological insult. CD169+ macrophage subsets are crucial for protection under excessive inflammatory conditions. They control inflammatory responses via interleukin-10 (IL-10) and may serve as a potential therapeutic target under damaging inflammatory conditions.
Article
Endocrinology & Metabolism
Marlina O. Cordoba-Moreno, Gabriela Christine Santos, Sandra M. Muxel, Debora dos Santos-Silva, Caroline L. Quiles, Kassiano D. S. Sousa, Regina P. Markus, Pedro Augusto C. M. Fernandes
Summary: Immune-pineal axis activation is involved in immune responses, and proinflammatory cytokines can inhibit pineal melatonin synthesis while inducing it in macrophages. IL-10 regulates melatonin synthesis in different cells through interactions between NF-κB subunits and (p)STAT3.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Immunology
D. Alejandro Canaria, J. Alejandra Rodriguez, Luopin Wang, Franklin J. Yeo, Bingyu Yan, Mengbo Wang, Charlotte Campbell, Majid Kazemian, Matthew R. Olson
Summary: Tox is expressed in various T cell subtypes and promotes the differentiation of Th2 and Treg cells. Its overexpression induces the expression of genes involved in cell activation, cellular trafficking, and inflammation suppression. Tox regulates the transcription of these genes along with BATF, IRF4, and JunB.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Shuang Qiu, Shengpei Wang, Weiwei Peng, Weibo Yi, Chuncheng Zhang, Jing Zhang, Huiguang He
Summary: Continuous theta-burst stimulation (cTBS) induces long-lasting inhibitory effects on cortical excitability and leads to improvements in motor function. Changes in microstate B were found to be associated with improvements in motor function, indicating a specific modulation by cTBS on motor network connectivity.
COGNITIVE NEURODYNAMICS
(2022)
Article
Cell Biology
Julian A. Chamucero-Millares, David A. Bernal-Estevez, Carlos A. Parra-Lopez
Summary: Clonal anergy and antigen-specific CD8+ T cell depletion are common in immunosuppressed patients;
Comparative study on PBMCs and moDCs revealed efficiency in expanding antigen-specific CD8+ T cells;
IL-7, IL-15, and IL-21 supplemented media facilitate expansion of different CD8+ T cell subsets.
CELLULAR IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Po-Kai Yang, Chia-Hung Chou, Chu-Chun Huang, Wen-Fen Wen, Hsin-Fu Chen, Chia-Tung Shun, Hong-Nerng Ho, Mei-Jou Chen
Summary: Obesity may disrupt normal folliculogenesis through increased production of IL-10 in visceral fats, shedding light on the association between obesity and ovulatory dysfunction in patients with polycystic ovary syndrome. However, the short duration of the study limits conclusions on long-term reproductive outcomes.
MOLECULAR METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Sera Sermet, Jinpeng Li, Anthony Bach, Robert B. Crawford, Norbert E. Kaminski
Summary: This study evaluated the impact of CBD on human primary monocytes activated through Toll-like receptors (TLR). The results showed that CBD suppressed the secretion of inflammatory cytokine IL-1β by monocytes activated through most TLRs, while also significantly modulating the production of IL-6. Most other immune mediators were not affected by CBD modulation.
Article
Immunology
Masashi Kanayama, Yuta Izumi, Megumi Akiyama, Toyoki Hayashi, Koji Atarashi, Axel Roers, Taku Sato, Toshiaki Ohteki
Summary: Emergency myelopoiesis is a hematopoietic response against systemic infections, but the role of lymphocytes in this process has not received much attention. This study found that a unique B cell subset expressing myeloid markers emerged in the bone marrow during emergency myelopoiesis, and these cells preferentially expressed IL-10, which stimulated hematopoietic progenitors for enhanced myeloid differentiation. Blocking IL-10 significantly suppressed emergency myelopoiesis and hindered microbial clearance in a model of cecal ligation and puncture. These findings suggest the importance of adaptive immune cells in boosting emergency myelopoiesis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Narmadha Subramanian, Beatriz Tavira, Kaisa Hofwimmer, Beate Gutsmann, Lucas Massier, Julie Abildgaard, Anders Juul, Mikael Ryden, Peter Arner, Jurga Laurencikiene
Summary: This study found that obesity and type 2 diabetes (T2D) affect the levels of WAT IL-10 in women, but not in men. The difference is likely attributed to obesity itself and not influenced by circulating sex hormones.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alessia Gallo, Nicola Cuscino, Flavia Contino, Matteo Bulati, Mariangela Pampalone, Giandomenico Amico, Giovanni Zito, Claudia Carcione, Claudio Centi, Alessandro Bertani, Pier Giulio Conaldi, Vitale Miceli
Summary: Studies have shown that MSC spheroids cultured in three dimensions exhibit enhanced therapeutic properties and can regulate processes such as proliferation/differentiation, immunomodulation, and angiogenesis. This represents a promising approach to cell-based therapy and has significant implications for regenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lavinia Raimondi, Alessia Gallo, Nicola Cuscino, Angela De Luca, Viviana Costa, Valeria Carina, Daniele Bellavia, Matteo Bulati, Riccardo Alessandro, Milena Fini, Pier Giulio Conaldi, Gianluca Giavaresi
Summary: This study reveals a novel role of miR-CT3 in regulating tumor angiogenesis and progression in osteosarcoma cells, as well as its association with the modulation of epithelial-mesenchymal transition proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Giovanni Zito, Vitale Miceli, Claudia Carcione, Rosalia Busa, Matteo Bulati, Alessia Gallo, Gioacchin Iannolo, Duilio Pagano, Pier Giulio Conaldi
Summary: This study aimed to define an in vitro model to test the effect of primed hAMSCs in reducing immune and hepatic cell damage caused by IRI. The results showed that IFN-gamma pre-treatment and 3D culture significantly reduced inflammation induced by M1-differentiated macrophages, and primed hAMSCs inhibited parenchymal apoptosis at early reperfusion timepoints by blocking the activation of caspase 3/7.
Article
Environmental Sciences
Valeria Longo, Gaspare Drago, Alessandra Longo, Silvia Ruggieri, Mario Sprovieri, Fabio Cibella, Paolo Colombo
Summary: There is growing evidence that environmental pollutants can induce epigenetic modifications altering miRNA expression and leading to pathological conditions in animals. This study found associations between serum concentrations of various inorganic and organic pollutants and the expression of miRNAs in pregnant women. These findings provide innovative early-warning approaches to human health risk assessment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Nutrition & Dietetics
Silvia Ruggieri, Gaspare Drago, Simona Panunzi, Giulia Rizzo, Elisa Eleonora Tavormina, Sabina Maltese, Fabio Cibella
Summary: During pregnancy, maternal nutrition and lifestyle have a crucial impact on fetal development and newborn health outcomes. This study investigates the factors influencing dietary patterns in pregnant women living in highly contaminated areas and explores whether women with higher environmental risk perception exhibit different nutrition behaviors during pregnancy.
Article
Environmental Sciences
S. Canepari, M. L. Astolfi, G. Drago, S. Ruggieri, E. E. Tavormina, F. Cibella, C. Perrino
Summary: This study aimed to identify and characterize indoor sources of particulate matter (PM) in domestic environments. The study evaluated 74 inhabited apartments in urban and rural areas of Gela, Italy for the elemental composition of PM2.5. The results showed that indoor air in the apartments was affected by both outdoor pollution and specific indoor emission sources, such as soil, industrial sources, heavy oil combustion, cigarette smoke, and use of vacuum dust cleaners. The study also found that cigarette smoke and heavy oil combustion increased health risks.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Ilaria Rocco, Giovanna Cilluffo, Giuliana Ferrante, Fabio Cibella, Alessandro Marcon, Pierpaolo Marchetti, Paolo Ricci, Nadia Minicuci, Stefania La Grutta, Barbara Corso
Summary: Parental socioeconomic position has an impact on a child's health, especially when parents have low education. The study found that low parental education directly affected family characteristics and exposure to passive smoking. It also indirectly influenced children's asthma and allergic rhinitis through maternal smoking during pregnancy and early environmental tobacco smoke.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Immunology
Valeria Longo, Noemi Aloi, Elena Lo Presti, Antonino Fiannaca, Alessandra Longo, Giorgia Adamo, Alfonso Urso, Serena Meraviglia, Antonella Bongiovanni, Fabio Cibella, Paolo Colombo
Summary: This study investigates the effects of PBDE-47 treatment on the miRNA cargo of sEVs and their downstream effects on bystander macrophages. The sEVs purified from PBDE-47 treated cells were found to modulate the expression of 12 miRNAs in resting THP-1 cells. Furthermore, PBDE-47 treatment may impair immune activity and down-regulate differentiation markers in macrophages. These findings suggest that PBDE-47 perturbs cellular regulatory pathways and affects macrophage differentiation markers by altering miRNA cargo.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Materials Science, Biomaterials
Miriam Romano, Manuel Antonio Gonzalez Gomez, Pamela Santonicola, Noemi Aloi, Svenja Offer, Jana Pantzke, Samuele Raccosta, Valeria Longo, Alessandro Surpi, Silvia Alacqua, Giuseppina Zampi, Valentin Alek Dediu, Bernhard Michalke, Ralf Zimmerman, Mauro Manno, Yolanda Pineiro, Paolo Colombo, Elia Di Schiavi, Jose Rivas, Paolo Bergese, Sebastiano Di Bucchianico
Summary: The SPIONs@SiO2-PDA nanoplatform developed in this study exhibits excellent biocompatibility, effectively protecting SPIONs and providing enhanced colloidal stability.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Giuseppina Cuttitta, Maria Ferraro, Fabio Cibella, Pietro Alfano, Salvatore Bucchieri, Angelo Maria Patti, Rosalba Muratori, Elisabetta Pace, Andreina Bruno
Summary: Adipose tissue is an endocrine organ that affects the severity of COPD. The role of adipocytokines and myokines in COPD is still controversial. This study evaluated the impact of body composition, leptin, adiponectin, haptoglobin, and irisin on exercise capacity, respiratory function, and QoL in COPD patients. The results showed increased levels of leptin, total adiponectin, and haptoglobin in COPD patients, along with decreased 6MWT and physical functioning scores. There were significant relationships between leptin/fat mass and 6MWT/nutritional status. Overall, this pilot study further supports the influence of body composition and adipocytokines on exercise capacity, respiratory function, and QoL in COPD.
Article
Medicine, Research & Experimental
Giusy Daniela Albano, Valeria Longo, Angela Marina Montalbano, Noemi Aloi, Rosario Barone, Fabio Cibella, Mirella Profita, Paolo Colombo
Summary: The study found that PBDE-47 treated macrophages release small extracellular vesicles (sEVs) with altered microRNA cargo, which affects the mRNA expression of lung epithelial cells, damaging their normal function and potentially contributing to the development of lung diseases.
Review
Biochemistry & Molecular Biology
Vitale Miceli, Matteo Bulati, Alessia Gallo, Gioacchin Iannolo, Rosalia Busa, Pier Giulio Conaldi, Giovanni Zito
Summary: Ischemia/reperfusion injury (IRI) is a harmful process that occurs when blood flow is interrupted and restored, causing cell death and tissue dysfunction. Current therapies are not effective, creating a need for new approaches. Emerging evidence shows that mesenchymal stem/stromal cells (MSCs) can reduce inflammation and promote tissue repair through paracrine effects. This review explores the potential use of MSCs and their secretome for treating IRI in various tissues/organs.
Article
Biology
Matteo Bulati, Alessia Gallo, Giovanni Zito, Rosalia Busa, Gioacchin Iannolo, Nicola Cuscino, Salvatore Castelbuono, Claudia Carcione, Claudio Centi, Gennaro Martucci, Alessandro Bertani, Maria Pia Baiamonte, Cinzia Maria Chinnici, Pier Giulio Conaldi, Vitale Miceli
Summary: This study investigated the effects of priming on the miRNA expression of MSCs and their exosomes. The results showed that different priming conditions led to distinct miRNA expression patterns in both MSCs and exosomes, but there were common deregulated miRNAs related to tissue repair/regeneration. The findings suggest that both 3D culture and IFN-gamma treatment can enhance the therapeutic potential of MSCs by modulating miRNA expression. Overall, this study provides valuable insights into the molecular mechanisms underlying the miRNA-mediated beneficial effects of MSCs.
Article
Biochemistry & Molecular Biology
Alessia Gallo, Nicola Cuscino, Claudia Carcione, Rosalia Busa, Pier Giulio Conaldi, Matteo Bulati
Summary: SARS-CoV-2, the virus responsible for COVID-19, has become a global public health hazard and despite vaccination efforts, it continues to pose a threat. Studies have shown that COVID-19 patients with ARDS treated with ECMO have a similar survival rate to those with non-COVID-19-related ARDS. This study examined the changes in the transcriptomic BCR repertoire in COVID-19 patients at different stages using single-cell V(D)J and gene expression sequencing.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Clinical Neurology
Federica Avorio, Gianvincenzo Sparacia, Giovanna Russelli, Aurelio Seidita, Giuseppe Mamone, Rossella Alduino, Fabio Tuzzolino, Salvatore Gruttadauria, Roberto Miraglia, Matteo Bulati, Vincenzina Lo Re
Summary: This study aimed to determine whether cerebral small vessels disease (cSVD) predicts acute neurological complications (NCs) in liver transplant patients aged 65 years or older. The results showed that more severe cSVD was associated with seizures, longer hospital stay, and disability. Hepatic encephalopathy and ascites were predictors of NCs after liver transplantation.
NEUROLOGY INTERNATIONAL
(2022)
