In silico identification of SARS-CoV-2 cell entry inhibitors from selected natural antivirals

Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein

(2020) Shuai Xia et al.   Cellular & Molecular Immunology

Arguments in favor of remdesivir for treating SARS-CoV-2 infections

(2020) Wen-Chien Ko et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

A Systematic Review of Lopinavir Therapy for SARS Coronavirus and MERS Coronavirus–A Possible Reference for Coronavirus Disease‐19 Treatment Option

(2020) Tian‐Tian Yao et al.   JOURNAL OF MEDICAL VIROLOGY

Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology

(2020) Eva Schrezenmeier et al.   Nature Reviews Rheumatology

First Case of 2019 Novel Coronavirus in the United States

(2020) Michelle L. Holshue et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quercetin blocks Ebola Virus infection by counteracting the VP24 Interferon inhibitory function

(2020) Elisa Fanunza et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection

(2020) Junwen Luan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Why Are Lopinavir and Ritonavir Effective against the Newly Emerged Coronavirus 2019? Atomistic Insights into the Inhibitory Mechanisms

(2020) Bodee Nutho et al.   BIOCHEMISTRY

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

(2020) Philippe Gautret et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19)

(2020) James M. Sanders et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Novel coronavirus treatment with ribavirin: Groundwork for an evaluation concerning COVID-19

(2020) Jahan S. Khalili et al.   JOURNAL OF MEDICAL VIROLOGY

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

(2020) Yeming Wang et al.   LANCET

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Remdesivir for the Treatment of Covid-19 — Preliminary Report

(2020) John H. Beigel et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

(2020) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

(2020) Wanchao Yin et al.   SCIENCE

Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19

(2020) Bo Yu et al.   Science China-Life Sciences

A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease

(2020) Donald C. Hall et al.   Travel Medicine and Infectious Disease

Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data

(2020) Matthieu Mahévas et al.   BMJ-British Medical Journal

Assessment of QT Intervals in a Case Series of Patients With Coronavirus Disease 2019 (COVID-19) Infection Treated With Hydroxychloroquine Alone or in Combination With Azithromycin in an Intensive Care Unit

(2020) Francis Bessière et al.   JAMA Cardiology

Experimental Treatment with Favipiravir for COVID-19: An Open-Label Control Study

(2020) Qingxian Cai et al.   Engineering

De novo design of protein peptides to block association of the SARS-CoV-2 spike protein with human ACE2

(2020) Xiaoqiang Huang et al.   Aging-US

Testing of natural products in clinical trials targeting the SARS-CoV-2 (Covid-19) viral spike protein-angiotensin converting enzyme-2 (ACE2) interaction

(2020) Gary Williamson et al.   BIOCHEMICAL PHARMACOLOGY

The genetic sequence, origin, and diagnosis of SARS-CoV-2

(2020) Huihui Wang et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening

(2020) Olga Abian et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Does lopinavir really inhibit SARS-CoV-2?

(2020) Dario Cattaneo et al.   PHARMACOLOGICAL RESEARCH

A review of therapeutic agents and Chinese herbal medicines against SARS-COV-2 (COVID-19)

(2020) Fangfang Huang et al.   PHARMACOLOGICAL RESEARCH

Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin

(2020) Petra Krafcikova et al.   Nature Communications

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

(2020) Andrea J. Pruijssers et al.   Cell Reports

Identification of SARS-CoV-2 Cell Entry Inhibitors by Drug Repurposing Using in silico Structure-Based Virtual Screening Approach

(2020) Shweta Choudhary et al.   Frontiers in Immunology

Clinical efficacy of antivirals against novel coronavirus (COVID-19): A review

(2020) Shahamah Jomah et al.   Journal of Infection and Public Health

Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection

(2020) Mayla Gabriela Silva Borba et al.   JAMA Network Open

Efficacy of Remdesivir in COVID-19

(2020) Erin K. McCreary et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Identification of a repurposed drug as an inhibitor of Spike protein of human coronavirus SARS-CoV-2 by computational methods

(2020) Sruthi Unni et al.   JOURNAL OF BIOSCIENCES

Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

(2020) Peter W Horby et al.   LANCET

Assessment of the efficacy and safety of Ribavirin in treatment of coronavirus-related pneumonia (SARS, MERS and COVID-19)

(2020) Yinhua Wang et al.   MEDICINE

Glycyrrhizic acid exerts inhibitory activity against the spike protein of SARS-CoV-2

(2020) Shaopeng Yu et al.   PHYTOMEDICINE

Neuropilin-1 is a host factor for SARS-CoV-2 infection

(2020) James L. Daly et al.   SCIENCE

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

(2020) Ludovico Cantuti-Castelvetri et al.   SCIENCE

Potential compound from herbal food of rhizoma polygonati for treatment of COVID-19 analyzed by network pharmacology and molecular docking technology

(2020) Chenglin Mu et al.   Journal of Functional Foods

Computational selection of flavonoid compounds as inhibitors against SARS-CoV-2 main protease, RNA-dependent RNA polymerase and spike proteins: A molecular docking study

(2020) Marimuthu Ragavan Rameshkumar et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Quercetin as a Natural Therapeutic Candidate for the Treatment of Influenza Virus

(2020) Parvaneh Mehrbod et al.   Biomolecules

Network pharmacology, molecular docking integrated surface plasmon resonance technology reveals the mechanism of Toujie Quwen Granules against coronavirus disease 2019 pneumonia

(2020) Miaobo Ye et al.   PHYTOMEDICINE

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

(2019) Ariane J. Brown et al.   ANTIVIRAL RESEARCH

Characteristics of flavonoids as potent MERS‐CoV 3C‐like protease inhibitors

(2019) Seri Jo et al.   Chemical Biology & Drug Design

High quality of life, treatment tolerability, safety and efficacy in HIV patients switching from triple therapy to lopinavir/ritonavir monotherapy: A randomized clinical trial

(2018) Juan Pasquau et al.   PLoS One

Clinical outcomes of current medical approaches for Middle East respiratory syndrome: A systematic review and meta-analysis

(2018) Mostafa Ebraheem Morra et al.   REVIEWS IN MEDICAL VIROLOGY

Improved Oral Absorption of Quercetin from Quercetin Phytosome®, a New Delivery System Based on Food Grade Lecithin

(2018) Antonella Riva et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

(2017) Timothy P. Sheahan et al.   Science Translational Medicine

Regulation of protein-ligand binding affinity by hydrogen bond pairing

(2016) D. Chen et al.   Science Advances

OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

(2015) Edward Harder et al.   Journal of Chemical Theory and Computation

Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry

(2015) Wenjiao Wu et al.   Viruses-Basel

Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study

(2014) Jaffar A. Al-Tawfiq et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

(2013) G. Madhavi Sastry et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris

(2012) Thi Thanh Hanh Nguyen et al.   BIOTECHNOLOGY LETTERS

Water Model Tuning for Improved Reproduction of Rotational Diffusion and NMR Spectral Density

(2012) Kazuhiro Takemura et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Biflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro inhibition

(2010) Young Bae Ryu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Towards the comprehensive, rapid, and accurate prediction of the favorable tautomeric states of drug-like molecules in aqueous solution

(2010) Jeremy R. Greenwood et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN