Liver damage promotes pro‐inflammatory T‐cell responses against apolipoprotein B‐100

Nonalcoholic Fatty Liver Disease Pandemic Fuels the Upsurge in Cardiovascular Diseases

(2020) Jingjing Cai et al.   CIRCULATION RESEARCH

Pathogenic Autoimmunity in Atherosclerosis Evolves from Initially Protective ApoB-Reactive CD4 + T-Regulatory Cells

(2020) Dennis Wolf et al.   CIRCULATION

Immunity and Inflammation in Atherosclerosis

(2019) Dennis Wolf et al.   CIRCULATION RESEARCH

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

Immune Responses in the Liver

(2018) Paul Kubes et al.   Annual Review of Immunology

Regulatory CD4+T Cells Recognize MHC-II-Restricted Peptide Epitopes of Apolipoprotein B

(2018) Takayuki Kimura et al.   CIRCULATION

LDL-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice

(2018) Anton Gisterå et al.   CIRCULATION

Hypercholesterolemia induces T cell expansion in humanized immune mice

(2018) Jonathan D. Proto et al.   JOURNAL OF CLINICAL INVESTIGATION

Association between non-alcoholic fatty liver disease and subclinical coronary atherosclerosis: An observational cohort study

(2018) Seung Bum Lee et al.   JOURNAL OF HEPATOLOGY

Alternative Splicing of FOXP3—Virtue and Vice

(2018) Reiner K. W. Mailer   Frontiers in Immunology

Role of Innate Immune Signaling in Non-Alcoholic Fatty Liver Disease

(2018) Jingjing Cai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Gregory A Roth et al.   LANCET

Vaccination against T-cell epitopes of native ApoB100 reduces vascular inflammation and disease in a humanized mouse model of atherosclerosis

(2017) A. Gisterå et al.   JOURNAL OF INTERNAL MEDICINE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Induction of Dendritic Cell–Mediated Activation of T Cells From Atherosclerotic Plaques by Human Heat Shock Protein 60

(2017) Mizanur Rahman et al.   Journal of the American Heart Association

Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population

(2017) Reiner K. W. Mailer et al.   Scientific Reports

Modelling the impact of alcohol consumption on cardiovascular disease mortality for comparative risk assessments: an overview

(2016) Jürgen Rehm et al.   BMC PUBLIC HEALTH

Hepatitis C Virus Infection Is Associated With Increased Cardiovascular Mortality: A Meta-Analysis of Observational Studies

(2016) Salvatore Petta et al.   GASTROENTEROLOGY

Bile salt export pump-reactive antibodies form a polyclonal, multi-inhibitory response in antibody-induced bile salt export pump deficiency

(2015) Jan Stindt et al.   HEPATOLOGY

Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up

(2015) Mattias Ekstedt et al.   HEPATOLOGY

The intrahepatic expression levels of bile acid transporters are inversely correlated with the histological progression of nonalcoholic fatty liver disease

(2015) Kazuya Okushin et al.   JOURNAL OF GASTROENTEROLOGY

Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Is Marked by a Higher Frequency of Th17 Cells in the Liver and an Increased Th17/Resting Regulatory T Cell Ratio in Peripheral Blood and in the Liver

(2015) Monika Rau et al.   JOURNAL OF IMMUNOLOGY

IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3

(2015) Reiner K. W. Mailer et al.   Scientific Reports

Nonalcoholic fatty liver disease and serum lipoproteins: The Multi-Ethnic Study of Atherosclerosis

(2013) Andrew Paul DeFilippis et al.   ATHEROSCLEROSIS

A novel hypothesis for an alkaline phosphatase ‘rescue’ mechanism in the hepatic acute phase immune response

(2013) Adrianne F. Pike et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Transforming Growth Factor-  Signaling in T Cells Promotes Stabilization of Atherosclerotic Plaques Through an Interleukin-17-Dependent Pathway

(2013) A. Gistera et al.   Science Translational Medicine

Regulatory T-Cell Response to Apolipoprotein B100–Derived Peptides Reduces the Development and Progression of Atherosclerosis in Mice

(2012) Olivier Herbin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Circulating levels of interleukin-17 and cardiovascular outcomes in patients with acute myocardial infarction

(2012) Tabassome Simon et al.   EUROPEAN HEART JOURNAL

Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease

(2011) Y. Tang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Identification of Circulating Human Antigen-Reactive CD4+FOXP3+ Natural Regulatory T Cells

(2011) N. H. R. Litjens et al.   JOURNAL OF IMMUNOLOGY

Nonalcoholic Fatty Liver Disease as the Transducer of Hepatic Oversecretion of Very-Low-Density Lipoprotein–Apolipoprotein B-100 in Obesity

(2010) Dick C. Chan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Expression of IL-17A in human atherosclerotic lesions is associated with increased inflammation and plaque vulnerability

(2010) Christian Erbel et al.   BASIC RESEARCH IN CARDIOLOGY

Peptide binding predictions for HLA DR, DP and DQ molecules

(2010) Peng Wang et al.   BMC BIOINFORMATICS

The Th17/Treg imbalance in patients with acute coronary syndrome

(2008) Xiang Cheng et al.   CLINICAL IMMUNOLOGY

Treatment with apo B peptide vaccines inhibits atherosclerosis in human apo B-100 transgenic mice without inducing an increase in peptide-specific antibodies

(2008) G. N. Fredrikson et al.   JOURNAL OF INTERNAL MEDICINE