Article
Medicine, General & Internal
Vartika Kesarwani, Deep Phachu, Ruchir Trivedi
Summary: Hypocomplementemia urticarial vasculitis syndrome is a rare form of systemic vasculitis characterized by recurrent and chronic urticarial rash, which shares similar pathophysiology with systemic lupus erythematosus.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Urology & Nephrology
Alice Corthier, Marie Jachiet, Daniel Bertin, Aude Servais, Christelle Barbet, Adrien Bigot, Marie-Sylvie Doutre, Didier Bessis, Ancuta Bouffandeau, Olivier Moranne, Pierre-Andre Jarrot, Nathalie Bardin, Benjamin Terrier, Stephane Burtey, Xavier Puechal, Laurent Daniel, Noemie Jourde-Chiche
Summary: This study describes the kidney involvement of hypocomplementemic urticarial vasculitis (HUV). Patients often present with proteinuria and acute kidney injury. Kidney biopsy shows mostly membrano-proliferative glomerulonephritis or crescentic glomerulonephritis, with frequent C1q deposits. Follow-up results indicate that some patients maintain good renal function, but others develop chronic kidney disease and end-stage kidney disease.
Article
Immunology
Adriana Coracini Tonacio, Ana Paula Marchi, Maria Luiza Bazzo, Gabriela Takeshigue Lemos, Jose Victor Bortolotto Bampi, Evelyn Patricia Sanchez Espinoza, Edson Luiz Tarsia Duarte, Roberta Cristina Ruedas Martins, Ana Paula Ramalho da Costa-Lourenco, Vitor Falcao de Oliveira, Marina Farrel Cortes, Sania Alves dos Santos, Lauro Vieira Perdigao Neto, Raquel Regina Bonelli, Maria Rita Elmore, Flavia Rossi, Gwenda Hughes, Silvia Figueiredo Costa
Summary: This study presents a rare case of gonococcal arthritis in a patient with Systemic Lupus Erythematosus (SLE). Whole genome sequencing (WGS) and molecular analysis were performed on the etiologic agent, which was found to be resistant to ciprofloxacin and tetracycline. The isolate had genetic features related to beta-lactam, tetracycline, and quinolone resistance, and 71 virulence genes were identified.
MICROBES AND INFECTION
(2023)
Review
Biochemistry & Molecular Biology
Patrizia Leone, Marcella Prete, Eleonora Malerba, Antonella Bray, Nicola Susca, Giuseppe Ingravallo, Vito Racanelli
Summary: Lupus vasculitis is a common complication occurring in approximately 50% of patients with systemic lupus erythematosus, involving different organ systems and presenting with various clinical manifestations. A poor prognosis is often associated with lupus vasculitis, requiring prompt diagnosis for a better outcome. Treatment strategies depend on the organs involved and the severity of the vasculitis.
Review
Rheumatology
Resit Yildirim, Tatiana Oliveira, David Alan Isenberg
Summary: In recent years, there have been efforts to improve the prognosis and outcome in patients with autoimmune inflammatory rheumatic diseases by using treat-to-target strategy and early intervention strategies with immunosuppressive agents. However, infectious complications due to medication side effects remain a major concern. Vaccination programmes and vaccine immunity play a crucial role in patients with SLE in terms of morbidity and mortality. Although research on vaccines' efficacy and immune response in immunosuppressed patients has increased, there is still a lack of data investigating these parameters for those receiving biological agents, leading to a lack of consensus on a vaccination policy for patients with SLE.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Medicine, General & Internal
Ya Lan Chen, Jie Meng, Cong Li
Summary: Intestinal perforation is a rare complication of systemic lupus erythematosus (SLE). This study retrospectively collected and analyzed the clinical data of 18 cases of SLE-related intestinal perforation. The results suggest that risk factors for intestinal perforation in SLE include disease duration of >5 years, SLE disease activity index score of >10, nonstandard use of steroids, and concomitant presence of other immune system diseases. Early diagnosis, aggressive resuscitation, antibiotics, steroid therapy, and prompt surgical intervention are key to successfully managing such cases.
Article
Infectious Diseases
Regina Selb, Susanne Buder, Sandra Dudareva, Thalea Tamminga, Viviane Bremer, Sebastian Banhart, Dagmar Heuer, Klaus Jansen
Summary: The study found a concerning increase in Neisseria gonorrhoeae isolates with elevated azithromycin minimum inhibitory concentrations in Germany from 2014 to 2021, suggesting a challenge to the recommended dual therapy for non-adherent patients in the country. These findings highlight the importance of antimicrobial susceptibility testing in clinical practice and continuous surveillance of susceptibility trends.
Article
Medicine, General & Internal
Ella Claire Berry, Jane Wells, Adrienne Morey, Anthea Anantharajah
Summary: The case presented a 70-year-old male patient with a variety of symptoms and persistent hypocomplementemia and positive anti-C1q antibodies, eventually achieving disease control with mycophenolate and prednisolone.
Article
Medicine, General & Internal
Honglei Ma, Yuqun Wang, Junhong Liu, Linping Du, Xiaodong Wang, Yingliang Wang
Summary: This is a case of a patient with SLE complicated with cryptococcal meningitis. Due to the lack of specificity of clinical symptoms, it is easily misdiagnosed as neuropsychiatric lupus or tuberculous meningitis, leading to delayed treatment. Through this case, the early improvement of India ink stain of cerebrospinal fluid and metagenomic next generation sequences to identify microbial infection is suggested, along with early empirical anti-infection therapy.
Article
Microbiology
Todd M. Pryce, Olivia R. Foti, Erin J. Haygarth, David M. Whiley
Summary: In this study, we compared different supplementary approaches for confirming NG-positive samples from the cobas 4800 CT/NG and cobas 6800 CT/NG assays. The results showed that using MagNA Pure 96 nucleic acid extraction technique for supplementary testing had higher confirmatory rates and more accurate prediction of ciprofloxacin susceptibility.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
David Brenes-Castro, Enma Toledo-Aleman, Jardiel Arguello Bolanos, Laura Victoria Torres Araujo, Diego Araiza-Garaygordobil
Summary: A 26-year-old woman with a history of SLE presented with acute onset angina and was diagnosed with an inferior STEMI and right coronary artery occlusion. Coronary angiography revealed left coronary artery ectasia and no PCI was performed. This is a case of acute myocardial infarction caused by CAV in a patient with SLE.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Immunology
Eric Y. Lin, Paul C. Adamson, Xiaomeng Deng, Jeffrey D. Klausner
Summary: This study compiled a global collection of Neisseria gonorrhoeae strains with decreased susceptibility to ceftriaxone and assessed the genetic characteristics associated with this phenomenon. Molecular algorithms based on genetic mutations were proposed to predict decreased susceptibility to ceftriaxone in N. gonorrhoeae, which may serve as a foundation for the development of future assays predicting ceftriaxone decreased susceptibility globally.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Rheumatology
Ummusen Kaya Akca, Ezgi Deniz Batu, Aysenur Pac Kisaarslan, Hakan Poyrazoglu, Nuray Aktay Ayaz, Betul Sozeri, Erdal Sag, Erdal Atalay, Selcan Demir, Serife Gul Karadag, Ferhat Demir, Yelda Bilginer, Fatma Gumruk, Seza Ozen
Summary: Hematological abnormalities are frequently encountered in pediatric SLE patients, with positive antiphospholipid antibodies and high SLEDAI scores associated with hematological involvement.
Article
Immunology
Claire C. Bristow, Tatum D. Mortimer, Sheldon Morris, Yonatan H. Grad, Olusegun O. Soge, Erika Wakatake, Rushlenne Pascual, Sara McCurdy Murphy, Kyra E. Fryling, Paul C. Adamson, Jo-Anne Dillon, Nidhi R. Parmar, Hai Ha Long Le, Hung Van Le, Reyna Margarita Ovalles Urena, Nireshni Mitchev, Koleka Mlisana, Teodora Wi, Samuel P. Dickson, Jeffrey D. Klausner
Summary: By analyzing the genome sequencing and phenotypic antimicrobial susceptibility data of global N. gonorrhoeae isolates, it was found that a single genetic marker, gyrA codon 91, can accurately predict susceptibility to ciprofloxacin. However, multiple genetic markers are needed to accurately predict susceptibility to other antimicrobials.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Xiao-Huan Chen, Jia-Cheng Shi, James Cheng-Chung Wei, Hsin-Hua Chen, Han-You Mo
Summary: This study revealed that patients with SLE had a significantly higher risk of retinal vasculitis (RV) compared to non-SLE individuals. The association between SLE and the risk of RV was examined using the Cox proportional hazard model and after adjusting for potential confounders.
FRONTIERS IN MEDICINE
(2021)
Article
Infectious Diseases
Hitoshi Yonezawa, Shingo Tanaka, Makito Tanaka, Ryo Kobayashi, Satoshi Takahashi
Summary: The aim of this study was to identify the risk factors for false positives in high-sensitivity HBsAg quantitative tests and reduce the need for neutralization tests. The results showed that younger age, female sex, lower HBsAg values, and reagent improvement were independent risk factors for false positives. The false-positive rate was highest in the range of 0.005-0.049 IU/mL.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)
Article
Infectious Diseases
Nobuaki Kobayashi, Katsushi Tanaka, Suguru Muraoka, Kohei Somekawa, Ayami Kaneko, Sousuke Kubo, Hiromi Matsumoto, Hiroaki Fujii, Keisuke Watanabe, Nobuyuki Horita, Yu Hara, Takeshi Kaneko
Summary: This study identified age, a negative T-SPOT.TB result, elevated CRP levels, and a high NLR as significant independent risk factors for death in hospitalized TB patients. These findings underscore the importance of these parameters in the risk stratification and management of hospitalized TB patients.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)
Article
Infectious Diseases
Naokuni Hishiya, Kenji Uno, Akiyo Nakano, Mitsuru Konishi, Seiya Higashi, Shuhei Eguchi, Tadashi Ariyoshi, Asami Matsumoto, Kentaro Oka, Motomichi Takahashi, Yuki Suzuki, Saori Horiuchi, Nobuyasu Hirai, Yoshihiko Ogawa, Taku Ogawa, Ryuichi Nakano, Keiichi Mikasa, Kei Kasahara, Hisakazu Yano
Summary: This study revealed intestinal dysbiosis near a CD4 count of 350 in HIV-infected patients undergoing cART. These findings contribute to the understanding of intestinal damage and systemic inflammation in HIV infection.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)