Article
Immunology
Anne-Marie C. Overstreet, Amanda E. Ramer-Tait, Jan S. Suchodolski, Jesse M. Hostetter, Chong Wang, Albert E. Jergens, Gregory J. Phillips, Michael J. Wannemuehler
Summary: Research shows that the composition of the cecal microbiota in IL-10(-/-) mice changes as inflammation progresses, leading to a biphasic progression in disease severity. While the overall diversity of the microbiota is similar in young mice, IL-10(-/-) mice fail to increase in complexity as they mature.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zachary B. Bjornson-Hooper, Gabriela K. Fragiadakis, Matthew H. Spitzer, Han Chen, Deepthi Madhireddy, Kevin Hu, Kelly Lundsten, David R. McIlwain, Garry P. Nolan
Summary: Animal models play an important role in drug development and evaluation, but they imperfectly reflect human immunological behavior. In this study, we measured immune cell signaling responses in humans and several model organisms using mass cytometry and identified differences in cellular phenotypes and immune signaling events between species.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Holly C. Webster, Virginia Gamino, Anna T. Andrusaite, Olivia J. Ridgewell, Jack McCowan, Amy L. Shergold, Graham A. Heieis, Simon W. F. Milling, Rick M. Maizels, Georgia Perona-Wright
Summary: This study finds that IL-10 promotes Th2 differentiation during helminth infection by suppressing Th1 cells. These findings are important for understanding the regulation of Type 2 immunity.
MUCOSAL IMMUNOLOGY
(2022)
Article
Virology
Dayvson Mauricio da Silva, Juliana Prado Goncales, Jose Valter Joaquim Silva Junior, Thaisa Regina Rocha Lopes, Luan Araujo Bezerra, Virginia Maria Barros de Lorena, Maria Rosangela Cunha Duarte Coelho
Summary: In HIV/HHV-8 coinfection, levels of cytokines IL-4, IL-6, and IL-10 are higher in patients compared to those infected with only HIV, potentially indicating the development of HHV-8-related diseases. On the other hand, levels of IL-2, TNF-alpha, and IFN-gamma show no significant difference between the two groups.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Food Science & Technology
Chia-Ying Lin, Sheng-Yi Chen, Wei-Ting Lee, Gow-Chin Yen
Summary: Camellia oil, rich in oleic acid and antioxidants, has been found to enhance phagocytosis in macrophages, reduce nitric oxide production, induce interleukin-10, and promote the CD19+ B cell population, showing significant immunomodulatory effects.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Immunology
Tetsuo Nakayama, Akihito Sawada, Takeshi Ito
Summary: The study found that the injection of recombinant zoster vaccine in mice can result in an increase in the production of inflammatory cytokines, which may be the cause of local adverse events in humans.
Article
Cell Biology
Nir Yogev, Tanja Bedke, Yasushi Kobayashi, Leonie Brockmann, Dominika Lukas, Tommy Regen, Andrew L. Croxford, Alexei Nikolav, Nadine Hovelmeyer, Esther von Stebut, Marco Prinz, Carles Ubeda, Kevin J. Maloy, Nicola Gagliani, Richard A. Flavell, Ari Waisman, Samuel Huber
Summary: Interleukin (IL)-10 is a prototypical anti-inflammatory cytokine that plays a role in immune homeostasis. In CNS inflammation, T-cell-derived IL-10 can promote inflammation and enhance autoimmunity.
Article
Immunology
Ishwarya Sankaranarayanan, Diana Tavares-Ferreira, Juliet M. Mwirigi, Galo L. Mejia, Michael D. Burton, Theodore J. Price
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect of antineoplastic agents, causing pain in cancer patients and survivors. The immune checkpoint molecule ICOS may play a role in resolving CIPN pain, as observed in mice. ICOSaa treatment increases IL-10 expression and alleviates mechanical hypersensitivity, suggesting its potential use in clinical trials.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Environmental Sciences
Yunxiu Wang, Zhiwei Cao, He Zhao, Zhaowei Gu
Summary: This study found that Nonylphenol (NP) can exacerbate the inflammatory response of ovalbumin (OVA)-induced allergic rhinitis (AR). This exacerbating effect may be related to the TSLP-TSLPR/IL-7R and JAK1/2-STAT3 signaling pathways.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Nuno Carvalho, Elisabete Carolino, Helder Coelho, Ana Coias, Madalena Trindade, Joao Vaz, Brigitta Cismasiu, Catarina Moita, Luis Moita, Paulo Matos Costa
Summary: Appendicitis is a common surgical emergency, and this study suggests that allergic responses, specifically the involvement of eosinophils and interleukin-5, play significant roles in its pathophysiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Amene Raouf-Rahmati, Amir-Reza Ansar, Seyed Abdolrahim Rezaee, Seyedeh Maryam Hosseini, Justus G. Garweg, Sanaz Ahmadi Ghezeldasht, Soheila Vaghei, Mehdi Zarean, Seyed Aliakbar Shamsian, Elham Moghaddas
Summary: In patients with ocular toxoplasmosis, IL-10 and IL-17 expression in the aqueous humor is upregulated while TGF-beta is downregulated. This local immunoregulatory process may be an attempt to prevent tissue damage. The cytokine expression pattern in ocular tissues differs from that in peripheral blood mononuclear cells, indicating intraocular immune deviation.
Article
Biology
Jiro Sakai, Jiyeon Yang, Chao-Kai Chou, Wells W. Wu, Mustafa Akkoyunlu
Summary: Newborns have a lower humoral immune response than adults due to the immunoregulatory role of IL-10. This study found that both B-1 cells and non-B-1 cells in neonatal mice produce IL-10 in response to B cell antigen receptor (BCR) activation. The production of IL-10 is mediated by the activation of STAT5 and IL-6, and further activates STAT3. IL-10 secreted by neonatal non-B-1 cells can inhibit TNF-alpha secretion by macrophages.
Article
Medicine, General & Internal
Qingqing Lu, Zhenhua Zhu, Chaochao Tan, Hui Zhou, Yan Hu, Ge Shen, Pan Zhu, Gang Yang, Xiaobing Xie
Summary: The study found that levels of IL-10, IL-1 beta, MCP-1, TNF-alpha, and IL-4 were significantly higher in COVID-19 patients compared to non-COVID-19 patients, while IL-6 was only significantly higher than in healthy individuals and IP-10 was significantly lower than in patients with other diseases. The detection of these cytokines may assist in the clinical study of COVID-19, and IP-10 could potentially be an early elevation cytokine in COVID-19 patients.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Allergy
Yuting Tang, Qian Xu, Hui Luo, Xiaomei Yan, Gaoxiang Wang, Liang Hu, Jin Jin, David P. Witte, Rebecca A. Marsh, Liang Huang, Gang Huang, Jianfeng Zhou
Summary: This study found that the collaborative roles of IL-10 and IL-18 can drive a hyperinflammatory syndrome similar to hemophagocytic lymphohistiocytosis (HLH). The study also discovered that blocking IL-10 can be protective in patients with HLH.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kyunghee Kim, Hyeju Kim, Gun Yong Sung
Summary: The study indicates that short-term use of I3LA for approximately one week can effectively suppress the progression of atopic dermatitis and impact the expression of major constituent proteins of the skin barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ninaad Lasrado, Arunakumar Gangaplara, Chandirasegaran Massilamany, Rajkumar Arumugam, Allison Shelbourn, Mahima T. Rasquinha, Rakesh H. Basavalingappa, Gustavo Delhon, Shi-Hua Xiang, Asit K. Pattnaik, David Steffen, Jay Reddy
Summary: The study developed a live attenuated vaccine against Coxsackievirus B3, which prevented myocarditis and pancreatitis in mice by inducing virus-neutralizing antibodies and antigen-specific T cell responses, providing a potential candidate for vaccine studies.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Ninaad Lasrado, Rajkumar Arumugam, Mahima T. Rasquinha, Meghna Sur, David Steffen, Jay Reddy
Summary: The study demonstrated that the Mt10 vaccine can induce cross-protection against multiple CVB serotypes, including the ability to generate cross-reactive neutralizing antibodies for CVB1 and CVB4. The vaccine showed 92% efficacy in preventing myocarditis and pancreatitis caused by CVB4, with cross-reactive neutralizing antibodies against CVB1, CVB3, and CVB4 persisting in the animals. Evaluation of antigen-specific immune responses indicated the production of viral protein 1 (VP1)-reactive antibodies and VP1-specific CD4 T cells capable of producing multiple T cell cytokines. Furthermore, no viral nucleic acid was found in the heart or pancreas of vaccinated animals challenged with CVB4, suggesting the potential of the Mt10 vaccine for preventing heart and pancreatic diseases caused by enteroviruses.
Article
Multidisciplinary Sciences
Ninaad Lasrado, Nicholas Borcherding, Rajkumar Arumugam, Timothy K. Starr, Jay Reddy
Summary: Coxsackievirus B3-induced myocarditis is commonly studied in mice to understand viral pathogenesis. Single-cell RNA sequencing of heart cells revealed the involvement of myeloid cells, T cells, and fibroblasts in the disease. Communication networks and signaling pathways play a crucial role in regulating the cardiac cellular response.
Article
Biology
Mahima T. Rasquinha, Ninaad Lasrado, Erika Petro-Turnquist, Eric Weaver, Thiagarajan Venkataraman, Daniel Anderson, Uri Laserson, H. Benjamin Larman, Jay Reddy
Summary: In this study, the researchers analyzed the production of heart antigen antibodies in a mouse model of CVB3 myocarditis using the PhIP-Seq technique. They identified several previously unreported protein antibodies that may be relevant to human disease.
Article
Immunology
Mahima T. Rasquinha, Ninaad Lasrado, Meghna Sur, Kiruthiga Mone, Haowen Qiu, Jean-Jack Riethoven, Raymond A. Sobel, Jay Reddy
Summary: In this study, a live-attenuated CVB3 vaccine virus called Mt10 was developed, which protected genetically predisposed NOD mice from CVB4-triggered type 1 diabetes but did not alter the subsequent development of spontaneous diabetes. The vaccine induced significant levels of neutralizing antibodies, mainly of the IgG2c isotype, and the virus was not detected in vaccinated animals. Monitoring blood glucose levels and insulin antibodies helped predict vaccine responses.
Review
Immunology
Kiruthiga Mone, Ninaad Lasrado, Meghna Sur, Jay Reddy
Summary: In this review, the attributes of experimentally tested vaccines have been analyzed, and their merits, demerits or limitations, as well as their impact in preventing infections, especially myocarditis and type 1 diabetes, have been discussed.