4.5 Article

Fruit extract of red pitaya (Hylocereus undatus) prevents and reverses stress-induced impairments in the cholinergic and antioxidant systems of Caenorhabditis elegans

Journal

JOURNAL OF FOOD BIOCHEMISTRY
Volume 46, Issue 4, Pages -

Publisher

WILEY
DOI: 10.1111/jfbc.13981

Keywords

antioxidant potential; antioxidant system; C; elegans; microencapsulation process; pitaya; reactive oxygen species

Funding

  1. National Council for Scientific and Technological Development (CNPq)
  2. Research Support Foundation of the State of Rio Grande do Sul (FAPERGS)
  3. Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS) [19/2551-0001-873-8]
  4. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [303263/2018-0, 308009/2018-5]

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The study analyzed the antioxidant capacity of pitaya extract on the nematode and found that it was effective in preventing and repairing damage caused by oxidative stress. The potential applications of the extract include supplementation in foods, treatment of oxidative damage-related diseases, promotion of healthy aging, and fortification of the antioxidant system.
The addition of fruit to the diet is very important, and we can use nutraceutical and functional foods for this supplement. A little-known fruit is a red pitaya (Hylocereus undatus) that has been widely reported to have a high antioxidant potential. In this study, we analyzed the in vitro and in vivo antioxidant capacity of microencapsulated pitaya extract on the behavior, antioxidant, and nervous system of the nematode Caenorhabditis elegans. The worms were treated with fruit extract before and after juglone-induced stress, to determine the protective or curative effects of pitaya. We have been evaluated cholinergic, antioxidant, and behavioral biomarkers. We have evidenced that the pulp of pitaya contains antioxidant compounds and can serve as a potential nutraceutical product. In addition, the fruit extract was effective in preventing and/or reverse the stress-induced damages, even at high levels of chemical stress at all evaluated parameters. Practical applications The potential applications and uses aimed by this research are related to the supplementation of foods given the antioxidant effect. Our data suggested that the effect of the pitaya fruit microencapsulated pulp extract was effective to prevent and repair the damage caused by oxidative stress. Besides the use of this microencapsulated extract can be an auxiliary in the treatment of diseases related to oxidative damage as well as promoting senescent aging. Another important use is the application of this extract as a dietary supplement to fortify the antioxidant system.

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