Journal
JOURNAL OF CONTROLLED RELEASE
Volume 338, Issue -, Pages 46-55Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2021.08.022
Keywords
Photodynamic therapy; Photothermal therapy; Single 808 nm NIR light; In-situ O-2 generation; Multimodal imaging
Funding
- Jiangsu Six Category Outstanding Talent [2012-NY-031]
- Jiangsu Province Key Agricultural Research and Development Plan [BE2020347]
- Science and Technology Development Fund of Nanjing Medical University [NMUB2020031]
- National Natural Science Foundation of China [81401427]
- Jiangsu Collaborative Innovation Center of Biomedical Functional Materials
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A multifunctional nanoplatform composed of MoO3-x nanosheets, Ag nanocubes, and MnO2 nanoparticles was developed to overcome the limitations of traditional combination therapy of PDT and PTT. Hyperthermia and ROS were simultaneously generated under single NIR light irradiation. The nanoplatform depleted GSH and catalyzed the generation of O2 in tumor cells, providing a new strategy for efficient cancer treatment guided by multimodal imaging.
Traditional combination therapy of photodynamic therapy (PDT) and photothermal therapy (PTT) is limited in the field of clinical cancer therapy due to activation by light with separate wavelengths, insufficient O2 supply, antioxidant ability of glutathione (GSH) in tumor cell, and low penetration depth of light. Here, a multifunctional nanoplatform composed of MoO3-x nanosheets, Ag nanocubes, and MnO2 nanoparticles was developed to overcome these drawbacks. For this nanoplatform, hyperthermia and reactive oxygen species (ROS) were simultaneously generated under single 808 nm near-infrared (NIR) light irradiation. Once this nanoplatform accumulated in the tumor region, GSH was depleted by MnO2 and intracellular H2O2 was catalyzed by MnO2 to produce O2 to relieve hypoxia. Ultrasound (US) imaging confirmed in-situ O2 generation. Magnetic resonance (MR) imaging, photoacoustic (PA) imaging, and fluorescence imaging were used to monitor in vivo biodistribution of nanomaterials. This provides a paradigm to rationally design a single NIR laser induced multimodal imaging-guided efficient PDT/PTT cancer strategy.
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