A respirable HPV-L2 dry-powder vaccine with GLA as amphiphilic lubricant and immune-adjuvant

Vaccinology in the post−COVID-19 era

(2021) Rino Rappuoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RG1-VLP and Other L2-Based, Broad-Spectrum HPV Vaccine Candidates

(2021) Bettina Huber et al.   Journal of Clinical Medicine

Single-administration, thermostable human papillomavirus vaccines prepared with atomic layer deposition technology

(2020) Robert L. Garcea et al.   npj Vaccines

Quantification of Lung Fibrosis in IPF-Like Mouse Model and Pharmacological Response to Treatment by Micro-Computed Tomography

(2020) Francesca Ruscitti et al.   Frontiers in Pharmacology

Effects of drying method and excipient on the structure and physical stability of protein solids: Freeze drying vs. spray freeze drying

(2020) Tarun Tejasvi Mutukuri et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Evaluation of the thermal stability and the protective efficacy of spray-dried HPV vaccine, Gardasil® 9

(2019) Nitesh K. Kunda et al.   Human Vaccines & Immunotherapeutics

Subunit-based mucosal vaccine delivery systems for pulmonary delivery - Are they feasible?

(2019) Nirmal Marasini et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Understanding Dry Powder Inhalers: Key Technical and Patient Preference Attributes

(2019) Mark L. Levy et al.   ADVANCES IN THERAPY

Immunization: vital progress, unfinished agenda

(2019) Peter Piot et al.   NATURE

Drying Technologies for the Stability and Bioavailability of Biopharmaceuticals

(2018) Fakhrossadat Emami et al.   Pharmaceutics

Engineered sodium hyaluronate respirable dry powders for pulmonary drug delivery

(2017) Francesco Martinelli et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Minor capsid protein L2 polytope induces broad protection against oncogenic and mucosal human papillomaviruses

(2017) Somayeh Pouyanfard et al.   JOURNAL OF VIROLOGY

Secretory production of designed multipeptides displayed on a thermostable bacterial thioredoxin scaffold in Pichia pastoris

(2017) Gloria Spagnoli et al.   PROTEIN EXPRESSION AND PURIFICATION

Spray dried human and chimpanzee adenoviral-vectored vaccines are thermally stable and immunogenic in vivo

(2017) Sam Afkhami et al.   VACCINE

Broadly neutralizing antiviral responses induced by a single-molecule HPV vaccine based on thermostable thioredoxin-L2 multiepitope nanoparticles

(2017) Gloria Spagnoli et al.   Scientific Reports

Dry influenza vaccines: towards a stable, effective and convenient alternative to conventional parenteral influenza vaccination

(2016) Jasmine Tomar et al.   Expert Review of Vaccines

Evaluation of excipients for enhanced thermal stabilization of a human type 5 adenoviral vector through spray drying

(2016) Daniel A. LeClair et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Optimized Formulation of a Thermostable Spray-Dried Virus-Like Particle Vaccine against Human Papillomavirus

(2016) Sugandha Saboo et al.   MOLECULAR PHARMACEUTICS

Optimization of Spray Drying Conditions for Yield, Particle Size and Biological Activity of Thermally Stable Viral Vectors

(2016) Daniel A. LeClair et al.   PHARMACEUTICAL RESEARCH

Manufacturing costs of HPV vaccines for developing countries

(2016) Chaevia Clendinen et al.   VACCINE

Robust In Vitro and In Vivo Neutralization against Multiple High-Risk HPV Types Induced by a Thermostable Thioredoxin-L2 Vaccine

(2015) H. Seitz et al.   Cancer Prevention Research

Spray-dried amikacin sulphate powder for inhalation in cystic fibrosis patients: The role of ethanol in particle formation

(2015) Silvia Belotti et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Spray-Dried Influenza Antigen with Trehalose and Leucine Produces an Aerosolizable Powder Vaccine Formulation that Induces Strong Systemic and Mucosal Immunity after Pulmonary Administration

(2015) Tomás Sou et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Next generation prophylactic human papillomavirus vaccines

(2015) John T Schiller et al.   LANCET ONCOLOGY

Vaccines, new opportunities for a new society

(2014) R. Rappuoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A high-performance thioredoxin-based scaffold for peptide immunogen construction: proof-of-concept testing with a human papillomavirus epitope

(2014) Elena Canali et al.   Scientific Reports

Influence of Oxidation and Multimerization on the Immunogenicity of a Thioredoxin-L2 Prophylactic Papillomavirus Vaccine

(2013) Hanna Seitz et al.   Clinical and Vaccine Immunology

Evaluation of monophosphoryl lipid A as adjuvant for pulmonary delivered influenza vaccine

(2013) Harshad P. Patil et al.   JOURNAL OF CONTROLLED RELEASE

A Human Papillomavirus (HPV)In VitroNeutralization Assay That Recapitulates theIn VitroProcess of Infection Provides a Sensitive Measure of HPV L2 Infection-Inhibiting Antibodies

(2012) Patricia M. Day et al.   Clinical and Vaccine Immunology

Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 Agonist, Promotes Potent Systemic and Mucosal Responses to Intranasal Immunization with HIVgp140

(2012) Mauricio A. Arias et al.   PLoS One

Development and Characterization of Synthetic Glucopyranosyl Lipid Adjuvant System as a Vaccine Adjuvant

(2011) Rhea N. Coler et al.   PLoS One

New developments in dry powder pulmonary vaccine delivery

(2011) Tomás Sou et al.   TRENDS IN BIOTECHNOLOGY

Particle Size Influences the Immune Response Produced by Hepatitis B Vaccine Formulated in Inhalable Particles

(2010) Chandan Thomas et al.   PHARMACEUTICAL RESEARCH

The N-terminal region of the human papillomavirus L2 protein contains overlapping binding sites for neutralizing, cross-neutralizing and non-neutralizing antibodies

(2010) Ivonne Rubio et al.   VIROLOGY

Pulmonary Spray Dried Powders of Tobramycin Containing Sodium Stearate to Improve Aerosolization Efficiency

(2009) Chiara Parlati et al.   PHARMACEUTICAL RESEARCH

Potent anti-HPV immune responses induced by tandem repeats of the HPV16 L2 (20–38) peptide displayed on bacterial thioredoxin

(2009) Ivonne Rubio et al.   VACCINE

Heat-stable measles vaccine produced by spray drying

(2009) Satoshi Ohtake et al.   VACCINE