Article
Biochemistry & Molecular Biology
Iman Shirzaei Sani, Mostafa Rezaei, Ali Baradar Khoshfetrat, Donya Razzaghi
Summary: Chitosan and poly (epsilon-caprolactone) were combined to fabricate bone tissue engineering scaffolds with enhanced bioactivity and mechanical properties. The incorporation of chitosan-g-poly (epsilon-caprolactone) significantly decreased fiber diameter and hydroxyapatite nanoparticles enhanced mineralization and degradation of the scaffold. In vitro cytocompatibility assays showed high cell viability and proliferation, indicating the potential use of the microfabricated nanocomposite scaffolds in bone tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Textiles
S. Lakshmipriya, N. M. Imayathamizhan
Summary: The stacking of different layers of silk fabric reinforced polycaprolactone biocomposites improved mechanical properties due to sufficient mechanical interlocking and good interfacial bonding. The composite exhibited enhanced water uptake and weight loss, yet maintained adequate mechanical strength for biodegradable bone plate application. The changes in pH were negligible, indicating promise as an alternative implant with controlled biodegradation.
JOURNAL OF INDUSTRIAL TEXTILES
(2021)
Article
Engineering, Biomedical
Pegah Dehghanpour, Rahmatollah Emadi, Hamidreza Salimijazi
Summary: Bone tissue engineering (BTE) is an important method for the regeneration of bone defects. In this study, a new composite scaffold made of polycaprolactone (PCL) and hardystonite (HT) nanopowders was developed, showing significant improvements in mechanical properties and cell viability. The scaffold also demonstrated the ability to stimulate the development of hydroxyapatite (HA).
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Biomedical
Sally AbdulHussain Kadhum, Nassier A. Nassir
Summary: In this research, porous composites were successfully prepared and reinforced for bone scaffold applications. The functional groups, pore structure, and composition distribution of the materials were characterized using techniques such as FTIR, Atomic Force Microscopy (AFM), and Scanning Electron Microscopy (SEM).
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Chemistry, Physical
Ioana-Codruta Mirica, Gabriel Furtos, Ondine Lucaciu, Petru Pascuta, Mihaela Vlassa, Marioara Moldovan, Radu-Septimiu Campian
Summary: This research developed new electrospun membranes (EMs) based on PCL with nHAP and MET. Structural characterization was done using XRD and FTIR-ATR, showing different mechanical properties and structural features for membranes with different compositions. The new EMs with nHAP and MET could be promising materials for guided bone regeneration or tissue engineering.
Article
Nanoscience & Nanotechnology
Neda Zakeri, Hamid Reza Rezaie, Jafar Javadpour, Mahshid Kharaziha
Summary: A novel polycaprolactone-zeolite nanocomposite scaffold was developed for sustained release of cisplatin in bone cancer treatment. The scaffold exhibited high porosity and suitable pore diameters, and the release of cisplatin had a cytotoxic effect on MG63 cells through a pH-sensitive and sustained release mechanism.
JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES
(2022)
Review
Polymer Science
Xiangjun Yang, Yuting Wang, Ying Zhou, Junyu Chen, Qianbing Wan
Summary: PCL is widely used in bone tissue engineering for its good biocompatibility and slow degradation rate, and can be blended with other polymers and hydrogels to improve its properties. 3D printing techniques are utilized to fabricate PCL-based composite scaffolds for various clinical applications.
Article
Polymer Science
Ismail Ismail, Quratul Aini, Zulkarnain Jalil, Niyi Gideon Olaiya, Mursal Mursal, C. K. Abdullah, Abdul H. P. S. Khalil
Summary: This study fabricated a high-performance biocomposite by bonding coconut shell with waste plastic, with the optimal performance achieved at a 30/70 ratio of plastic waste to coconut shell. The study revealed that the performance of the biocomposite significantly improved with a lower percentage of matrix and filler nanoparticles, highlighting the potential for industrial applications as a panelboard.
Article
Polymer Science
Changxin Xiang, Qing Zhang, Zijian Guo, Zehua Wang, Weiyi Chen, Xiaona Li, Xiaochun Wei, Pengcui Li
Summary: In this study, a series of porous biocompatible composite hydrogels were designed for bone tissue engineering, consisting of poly(vinyl alcohol), trehalose, and nano-clay. These hydrogels exhibited excellent mechanical properties and microscopic structures, and had the ability to promote cell growth and bone defect repair. The concentrations of trehalose and nano-clay could be adjusted to control the mechanical properties and microscopic structures of the hydrogels.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Maria Alvarez Echazu, Sandra J. Renou, Gisela S. Alvarez, Martin F. Desimone, Daniel G. Olmedo
Summary: In this study, a chitosan-silica-based biocomposite was synthesized and characterized for its physicochemical properties and biocompatibility. The results showed that the biocomposite had good biocompatibility and could act as a template for cellular interactions and extracellular matrix formation, promoting new bone tissue formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Yubo Shi, Lei Wang, Liguo Sun, Zhennan Qiu, Xiaoli Qu, Jingyi Dang, Zhao Zhang, Jiankang He, Hongbin Fan
Summary: Melt electrospinning writing (MEW) is a promising 3D printing technology for scaffold fabrication. This study investigated the use of NaOH treatment to enhance the cytocompatibility and osteoinductive properties of polycaprolactone (PCL) scaffolds. The NaOH-treated PCL scaffold exhibited nanopits and nanogrooves on the surface, which increased surface roughness and wettability, leading to improved cell proliferation and adhesion. In vitro experiments demonstrated that the NaOH-treated surface could induce osteogenic differentiation of bone marrow mesenchymal stem cells via the integrin alpha 2/beta 1-PI3K-Akt signaling pathway. Animal studies showed that the NaOH-treated PCL scaffold promoted new bone formation. The study concluded that NaOH treatment is a simple and effective method to enhance the cellular affinity and osteoinductive property of MEW PCL scaffolds.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Polymer Science
Hosein Emadi, Mehdi Karevan, Maryam Masoudi Rad, Sorour Sadeghzade, Farnoosh Pahlevanzadeh, Mohammad Khodaei, Saber Khayatzadeh, Saeid Lotfian
Summary: This study investigated the relationship between the structure and mechanical properties of polycaprolactone (PCL) nanocomposites reinforced with baghdadite, a newly introduced bioactive agent. The addition of baghdadite improved the tensile strength, elastic modulus, and thermal properties of the nanocomposites. The nanocomposites also showed enhanced apatite-like layer formation and cell viability, making them promising for biomedical applications.
Article
Biotechnology & Applied Microbiology
Mustafa M. Kadhim, Dmitry Olegovich Bokov, Mohammad Javed Ansari, Wanich Suksatan, Mohammed Abed Jawad, Supat Chupradit, Mohammed N. Fenjan, Milad Kazemnejadi
Summary: In this study, blend nanofibrous scaffolds were electrospun using polycaprolactone/gelatin blend solutions reinforced by BMP-modified graphene oxide. The resulting nanofibers exhibited uniform and bead-less morphology with improved mechanical and physical properties due to the addition of PCL and GO. The incorporation of BMP-modified graphene in the blend led to the formation of nanofibrous substrate resembling bone tissue, which showed good biocompatibility with human osteosarcoma cells.
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Akram Nadi, Mohammad Khodaei, Moosa Javdani, Seyed Abbas Mirzaei, Mostafa Soleimannejad, Lobat Tayebi, Shiva Asadpour
Summary: Bone tissue engineering involves the manufacture of scaffolds for bone defects using ceramic nanoparticles. In this study, novel strontium-doped bredigite nanoparticles were synthesized and used to develop nanocomposite scaffolds. The scaffolds showed enhanced degradation rate and mechanical strength, as well as the ability to support the viability and proliferation of human osteoblasts. The inclusion of nanoparticles also resulted in significant differences in gene expression and calcium deposition. The scaffolds containing bredigite nanoparticles exhibited the best potential for bone tissue regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Maria Alvarez Echazu, Sandra Renou, Gisela Alvarez, Martin Desimone, Daniel Olmedo
Summary: Bone is a hierarchical material that has inspired the design of biopolymer-derived biocomposites for tissue engineering. The study synthesized a collagen-silica-based biocomposite and analyzed its ultrastructure, biodegradability, swelling behavior, and biocompatibility. In an in vivo experimental model, the biocomposite showed good biocompatibility properties and stimulated new bone formation.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Chemistry, Physical
Saeed Askari, Mohammad Mehdi Khodaei, Mohammad Jafarzadeh
Summary: This study reports the preparation and application of UiO-66-NH2-bis(aminomethyl)-phosphinic acid, which is designed via a multi-step post-synthesis modification of a Zr-based MOF, UiO-66-NH2. The modified MOF serves as a multifunctional heterogeneous catalyst in the multicomponent reaction of Hantzsch, showing a synergistic effect between the phosphinic acid and the support. The catalyst can be easily recycled and successfully reused multiple times.
Article
Materials Science, Multidisciplinary
Sayed Hossein Mirdamadi, Mohammad Khodaei, Alireza Valanezhad, Ikuya Watanabe, Farahnaz Nejatidanesh, Omid Savabi
Summary: Different heat treatment temperatures were applied to titanium implants after surface modification using chemical treatment with hydrogen peroxide. XRD analysis showed that the main phase on the surface of heat-treated samples below 650 ? was anatase. Raman spectroscopy confirmed the presence of anatase as the dominant phase along the Raman shift with noticeable peak intensity. FESEM observation indicated that the porous structures did not significantly change in morphology with increasing temperature. Contact angle and ellipsometry measurements were used to determine the hydrophobicity and optical properties of the oxide surface, respectively.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Article
Engineering, Biomedical
Sharareh Ghaziof, Shahrokh Shojaei, Mehdi Mehdikhani, Mohammad Khodaei, Milad Jafari Nodoushan
Summary: The human heart cannot regenerate itself after a wound, leading to damage and scar formation in myocardial tissue. To address this issue, scientists have proposed using 3D printing to create scaffolds with suitable properties. In this study, Poly epsilon-caprolactone (PCL)/Gold nanoparticles (GNPs) nanocomposite scaffolds were prepared using Fused Deposition Modeling (FDM) and characterized using various techniques. The results show that the scaffold containing 0.5 wt% GNPs exhibits optimal properties for cardiovascular applications.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Akram Nadi, Mohammad Khodaei, Moosa Javdani, Seyed Abbas Mirzaei, Mostafa Soleimannejad, Lobat Tayebi, Shiva Asadpour
Summary: Bone tissue engineering involves the manufacture of scaffolds for bone defects using ceramic nanoparticles. In this study, novel strontium-doped bredigite nanoparticles were synthesized and used to develop nanocomposite scaffolds. The scaffolds showed enhanced degradation rate and mechanical strength, as well as the ability to support the viability and proliferation of human osteoblasts. The inclusion of nanoparticles also resulted in significant differences in gene expression and calcium deposition. The scaffolds containing bredigite nanoparticles exhibited the best potential for bone tissue regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Multidisciplinary
Mohammad Khodaei, Farahnaz Nejatidanesh, Lobat Tayebi, Omid Savabi
Summary: In this study, lithium silicate glass frits with different SiO2/Li2O ratios were prepared by the melting method. The resulting glass frits were then hot-pressed at different temperatures to obtain lithium metasilicate glass ceramics (LMSGC). It was found that the wettability, hardness, and cell viability of LMSGC can be tuned by changing the SiO2/Li2O ratio, which is of great importance for dental applications.
MATERIALS TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Saeed Askari, Mohammad Mehdi Khodaei, Mohammad Jafarzadeh, Abdolhamid Mikaeili
Summary: In this study, a porous heterogeneous catalyst was prepared via green deposition of silver nanoparticles on the surface of a functionalized metal-organic framework. The catalyst showed effective catalytic activity for the reduction of 4-nitrophenol and cyanation of aryl halides, as well as prominent antibacterial activity against Staphylococcus aureus and Escherichia coli.
PROCESS BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Mohsen Karegar, Mohammad Mehdi Khodaei
Summary: In this study, a reusable magnetic catalyst was synthesized by immobilizing sulfonic acid on polythiophene-layered magnetite. The catalyst exhibited high catalytic efficiency for the green synthesis of compounds. Characterization techniques confirmed the successful attachment of the sulfonic group on the catalyst's surface. The increased number of acidic groups on the catalyst's surface led to enhanced yield, and the catalyst showed excellent stability and reusability.
Article
Materials Science, Multidisciplinary
Mojtaba Soleimanipour, Reza Abedinzadeh, Ali Heidari, Seyyed Ali Eftekhari
Summary: The study presents a numerical model for the friction stir extrusion process to produce wire from AA1050 aluminum alloy. The model was developed using finite element analysis and validated against experimental temperature measurements. The effect of process parameters on the outputs was investigated using Taguchi experiment design method and an orthogonal array.
Article
Chemistry, Physical
Nasim Batooie, Mohammad Mehdi Khodaei, Kiumars Bahrami, Seyyed Shahram Miraghaee, Nouraddin Hosseinzadeh, Soraya Sajadimajd
Summary: An efficient and environmentally friendly method using hexyltriphenylphosphonium bromide ionic liquid as a promoter and solvent has been developed for the synthesis of novel compounds. The method allows for the one-pot synthesis of the target products from CH acids, aldehydes, and 2-mercaptobenzimidazole at ambient temperature, with high yields and short reaction times. Furthermore, the synthesized compounds exhibit significant anti-cancer effects on skin, prostate, and pancreatic cancers.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Zahra Karami, Mohammad Mehdi Khodaei
Summary: A new metal-organic framework catalyst, UiO-66-N=CH-C6H3PO4H, was studied, which showed hydrogen phosphate groups as the main active catalytic sites on its surface. The catalyst exhibited durability and robustness in acid-catalyzed syntheses, making it a promising candidate for catalytic applications.
RESEARCH ON CHEMICAL INTERMEDIATES
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Saeid Rostami, Mohammad Mehdi Khodaei
Summary: Regarding the existence of cationic and anionic dyes in water, it is crucial to develop new techniques for their simultaneous removal. In this study, a chitosan/poly-2-aminothiazole composite film reinforced with multi-walled carbon nanotube-Mg Al-layered double hydroxide (CPML) was created and used as an effective adsorbent for methylene blue (MB) and methyl orange (MO) dyes removal. The synthesized CPML was characterized using SEM, TGA, FTIR, XRD, and BET methods. The highest adsorption capacities were found to be 471.12 and 230.87 mg g-1 for MB and MO, respectively. Different isotherm and kinetic models showed that the adsorption of dyes onto CPML nanocomposite (NC) followed the Langmuir and pseudo-second-order kinetic model, indicating monolayer adsorption on the homogeneous surface of NCs. The reusability experiment demonstrated that the CPML NC could be used multiple times. Experimental results suggest that the CPML NC has significant potential for treating cationic and anionic dye-contaminated water.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Pharmacology & Pharmacy
Hamed Nosrati, Morteza Heydari, Zahra Tootiaei, Saeid Ganjbar, Mohammad Khodaei
Summary: Skin serves as the primary barrier against pathogenic microorganisms and any significant damage to the skin can lead to bacterial invasion and wound infection. Effective wound management is crucial to prevent complications like tissue necrosis or sepsis, which can be life-threatening. Polysaccharide-based scaffolds containing antibacterial nanobiomaterials have gained interest for their immunological safety and ability to enhance wound healing by reducing bacterial colonization and infection. This review focuses on the delivery of antibacterial agents and nanobiomaterials via polysaccharide-based scaffolds for wound healing applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Bita Derakhshani, Nader Parvin, Mohammad Khodaei
Summary: This study investigated the effects of sintering temperature on the mechanical behavior and biocompatibility of Ti/HA FGMs produced via SPS. The results showed that raising the sintering temperature to 1150℃ resulted in the formation of TiO2 and TCP phases, reducing compressive strength and increasing hardness. Moreover, increasing the sintering temperature to 1150℃ enhanced the biocompatibility of the fabricated Ti/HA FGMs.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Article
Metallurgy & Metallurgical Engineering
Ali Moradi, Ali Heidari, Kamran Amini, Farshid Aghadavoudi, Reza Abedinzadeh
Summary: Shot peening improves the microstructure, hardness, wear resistance, surface roughness, and compressive residual stress of Ti-6Al-4V alloy. The treatment refines grains and creates a compact layer of nanostructure on the surface, leading to significant improvements in surface properties.
METALLURGICAL RESEARCH & TECHNOLOGY
(2022)