T cell receptors (TCRs) employ diverse strategies to target a p53 cancer neoantigen

Targeting a neoantigen derived from a common TP53 mutation

(2021) Emily Han-Chung Hsiue et al.   SCIENCE

Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variants

(2021) Rui Yin et al.   PLoS Computational Biology

The evolutionary history of 2,658 cancers

(2020) Moritz Gerstung et al.   NATURE

High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D

(2020) Malcolm J. W. Sim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen

(2020) Daichao Wu et al.   Nature Communications

Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer

(2019) Winifred Lo et al.   Cancer Immunology Research

Neoantigen screening identifies broad TP53 mutant immunogenicity in patients with epithelial cancers

(2019) Parisa Malekzadeh et al.   JOURNAL OF CLINICAL INVESTIGATION

TCR3d: The T cell receptor structural repertoire database

(2019) Ragul Gowthaman et al.   BIOINFORMATICS

Neoantigen quality, not quantity

(2019) Nicholas McGranahan et al.   Science Translational Medicine

A TCR β-Chain Motif Biases toward Recognition of Human CD1 Proteins

(2019) Peter Reinink et al.   JOURNAL OF IMMUNOLOGY

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer

(2018) Nikolaos Zacharakis et al.   NATURE MEDICINE

Cancer Neoantigens

(2018) Ton N. Schumacher et al.   Annual Review of Immunology

Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope

(2017) Xinbo Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

(2017) Ahmet Zehir et al.   NATURE MEDICINE

Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others

(2017) Kanaga Sabapathy et al.   Nature Reviews Clinical Oncology

Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer

(2017) Sanja Stevanović et al.   SCIENCE

T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer

(2016) Eric Tran et al.   NEW ENGLAND JOURNAL OF MEDICINE

Toward a Shared Vision for Cancer Genomic Data

(2016) Robert L. Grossman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adoptive cell transfer as personalized immunotherapy for human cancer

(2015) S. A. Rosenberg et al.   SCIENCE

Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations

(2014) Faviel F. González-Galarza et al.   NUCLEIC ACIDS RESEARCH

Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer

(2014) E. Tran et al.   SCIENCE

Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor

(2014) Brian G. Pierce et al.   PLoS Computational Biology

Lessons from the Cancer Genome

(2013) Levi A. Garraway et al.   CELL

Randomized Selection Design Trial Evaluating CD8+-Enriched Versus Unselected Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy for Patients With Melanoma

(2013) Mark E. Dudley et al.   JOURNAL OF CLINICAL ONCOLOGY

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A flexible docking approach for prediction of T cell receptor-peptide-MHC complexes

(2012) Brian G. Pierce et al.   PROTEIN SCIENCE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC

(2008) Jaafar N. Haidar et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS