Review
Medicine, General & Internal
Erico Murilo Monteiro Cutrim, Precil Diego Miranda de Meneses Neves, Marcos Adriano Garcia Campos, Davi Campos Wanderley, Antonio Augusto Lima Teixeira-Junior, Monique Pereira Rego Muniz, Francisco Rasiah Ladchumananandasivam, Orlando Vieira Gomes, Rafael Fernandes Vanderlei Vasco, Dyego Jose de Araujo Brito, Joyce Santos Lages, Natalino Salgado-Filho, Felipe Leite Guedes, Jose Bruno de Almeida, Marcelo Magalhaes, Stanley de Almeida Araujo, Gyl Eanes Barros Silva
Summary: Collapsing glomerulopathy (CG) is a clinicopathologic entity characterized by glomerular collapse, podocyte hypertrophy and hyperplasia. It is more prevalent among populations with African descent. Risk factors include APOL1 gene mutations, HIV infection, and SARS-CoV-2 infection. CG presents with severe symptoms and worse prognosis compared to other FSGS subtypes.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Mohammad A. Qamar, Lucas M. Kogut, Sameer S. Tebha, Aabiya Arif, Jesse Ninmol, Muhammad Abdul R. Razzaque, Khulud Qamar, Abubakr Yosufi
Summary: This study conducted a comprehensive review of the scientific literature from January 2020 to February 2022, focusing on collapsing glomerulopathy in patients with coronavirus disease-2019. The findings showed that respiratory system symptoms and hematuria were the most common clinical manifestations, while proteinuria and acute tubular injury were common laboratory and microscopic findings. The study also found a higher correlation between symptoms and microscopic results with collapsing glomerulopathy in the dialysis-dependent group.
ANNALS OF MEDICINE AND SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Hui Zhang, Qing-Qing Dong, Hua-Pan Shu, Yu-Chi Tu, Qian-Qian Liao, Li-Jun Yao
Summary: This study explored the mechanism of curcumin (CUR) against focal segmental glomerulosclerosis (FSGS) through network pharmacological methods and experimental verification. CUR was found to attenuate apoptosis, oxidative stress damage, and epithelial-mesenchymal transition (EMT) in FSGS by repressing the AKT signaling pathway.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Review
Urology & Nephrology
Ke Sun, Qionghong Xie, Chuan-Ming Hao
Summary: This study focuses on the potential sources and mechanism of podocyte supplementation in FSGS. Parietal epithelial cells (PECs) have gained attention for their role in the progression of FSGS, as both influencing factors in glomerulosclerosis lesions and their repair abilities are being debated. Other resident glomerular cells are also significant in the progression of the disease.
Article
Urology & Nephrology
Ying Zhu, Yun Fan, Feng Xu, Shaoshan Liang, Dandan Liang, Ping Li, Yuanyuan Xia, Xiaodong Zhu, Fan Yang, Jinsong Chen, Caihong Zeng
Summary: In this study, 60.6% of TG patients were found to have concomitant FSGS, which was associated with more severe clinicopathological features and worse allograft survival. The presence of FSGS in TG patients was independently associated with higher proteinuria, serum creatinine levels, chronic glomerulopathy score, and a higher kidney allograft loss rate.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dirk J. W. den Braanker, Rutger J. H. Maas, Guido van Mierlo, Naomi M. J. Parr, Marinka Bakker-van Bebber, Jeroen K. J. Deegens, Pascal W. T. C. Jansen, Jolein Gloerich, Brigith Willemsen, Henry B. B. Dijkman, Alain J. J. van Gool, Jack F. M. Wetzels, Markus M. M. Rinschen, Michiel Vermeulen, Tom Nijenhuis, Johan van der Vlag
Summary: This study aimed to investigate the possible factors and mechanisms leading to recurrence of focal segmental glomerulosclerosis (FSGS) after kidney transplantation. It was found that a protein called perilipin-2 was significantly increased in infiltrating cells of patients' glomeruli and was associated with lipid droplet accumulation, suggesting it as a potential biomarker. Further research should focus on understanding how these factors alter lipid metabolism in podocytes and provide new treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Sadichhya Lohani, Mohanraj Sadasivam, Hamid Rabb, Mohamed G. Atta
Summary: Collapsing glomerulopathy can be associated with various factors, including viral infections, medications, autoimmune diseases, and genetic predisposition. Studies suggest that the activation and elevated production of interferon gamma by double negative T cells may play a role in the progression of collapsing glomerulopathy.
Article
Oncology
Samy Hakroush, Svenja Wulf, Julia Gallwas, Bjoern Tampe
Summary: Ado-trastuzumab emtansine (T-DM1) is an antibody-drug conjugate approved for HER2-positive breast cancer. A study reported kidney biopsy findings of collapsing FSGS after initiation of T-DM1 therapy, highlighting the importance for nephrologists to be aware of this potentially severe complication due to T-DM1 usage.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Takaya Ozeki, Michio Nagata, Takayuki Katsuno, Koji Inagaki, Kazunori Goto, Sawako Kato, Yoshinari Yasuda, Naotake Tsuboi, Shoichi Maruyama
Summary: This study analyzed the clinical implication of unclassified segmental lesions in Japanese adult patients with nephrotic syndrome compared to Columbia-classified FSGS. The results showed that unclassified segmental lesions may have equivalent clinical impact as Columbia classification of FSGS, with similar treatment responses and no significant difference in the decline of eGFR.
Article
Radiology, Nuclear Medicine & Medical Imaging
Tyler Tancredi, Ami DeWaters, Kathryn L. McGillen
Summary: A case study of a 38-year-old Afro-Caribbean female with COVID-19 showed renal manifestations associated with collapsing focal segmental glomerulosclerosis (FSGS), not previously reported with this disease, highlighting the potential for diverse renal complications in different populations. These renal ultrasound findings, along with duplex Doppler, may serve as useful indicators for early diagnosis and treatment in COVID-19 patients.
Article
Pediatrics
Rachel K. Cason, Anna Williams, Megan Chryst-Stangl, Guanghong Wu, Kinsie Huggins, Kaye E. Brathwaite, Brandon M. Lane, Larry A. Greenbaum, Vivette D. D'Agati, Rasheed A. Gbadegesin
Summary: This article describes a sibling pair with NUP93 mutations and collapsing FSGS. Their findings suggest that mutations in NUP93 and other nucleoporin genes may be associated with familial cFSGS.
FRONTIERS IN PEDIATRICS
(2022)
Article
Urology & Nephrology
Mahmoud M. Sobh, Ghada El Kannishy, Fatma Moustafa, Riham Eid, Nashwa Hamdy, Samar Tharwat
Summary: This study found that detachment of podocytes can be accurately detected by light microscopy, providing important information for diagnosis and prognosis.
JOURNAL OF NEPHROLOGY
(2022)
Article
Transplantation
Lihong Bu, James Mirocha, Mark Haas
Summary: This study examined whether the IgG/albumin staining ratio in protein reabsorption droplets could help distinguish minimal change disease (MCD) from primary focal segmental glomerulosclerosis (FSGS). The results showed that a ratio ≤0.33 was more likely to indicate MCD, while a ratio of 1.0 was more likely to indicate FSGS.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Immunology
Vladimir Prelevic, Ivana Juric, Marijana Coric, Zeljko Kastelan, Nikolina Basic-Jukic
Summary: This case study explores the possible link between viral infections and cFSGS in patients who underwent kidney transplantation through three case reports.
TRANSPLANTATION PROCEEDINGS
(2023)
Article
Cell Biology
Laura Miesen, Peter Bandi, Brigith Willemsen, Fieke Mooren, Thiago Strieder, Eva Boldrini, Vedran Drenic, Jennifer Eymael, Roy Wetzels, Johannes Lotz, Nick Weiss, Eric Steenbergen, Toin H. van Kuppevelt, Merijn van Erp, Jeroen van der Laak, Nicole Endlich, Marcus J. Moeller, Jack F. M. Wetzels, Jitske Jansen, Bart Smeets
Summary: In focal segmental glomerulosclerosis (FSGS), the continuity of glomerular epithelial cells is disrupted, but non-sclerotic segments remain protected. Studies have shown that in FSGS, parietal epithelial cells (PECs) can cover the sclerotic lesions and restore the continuity of glomerular epithelial cells.
DISEASE MODELS & MECHANISMS
(2022)
Article
Pathology
Andrew Xiao, Jessica Van Ziffle, Emily Chan
Summary: Renal epithelioid angiomyolipoma (EAML) is a rare subtype of renal angiomyolipoma with aggressive behavior and diagnostic challenges. This report describes a renal EAML with unusual papillary architecture and tumor cells resembling FH-deficient RCC. The study highlights the morphologic, immunohistochemical, and molecular aspects of EAML, including differential diagnosis with FH-deficient RCC, TFEB-amplified RCC, and renal tumors with TSC1/2 alterations. Novel findings in this case include papillary morphology and a previously unreported telomerase reverse transcriptase promoter rearrangement.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2023)