Sex Differences in the Behavioral, Molecular, and Structural Effects of Ketamine Treatment in Depression

Sex differences in the genetic architecture of depression

(2020) Hee-Ju Kang et al.   Scientific Reports

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

(2020) Theo Vos et al.   LANCET

Antidepressant actions of ketamine engage cell-specific translation via eIF4E

(2020) Argel Aguilar-Valles et al.   NATURE

Sex differences in depression: Insights from clinical and preclinical studies

(2019) Rand S. Eid et al.   PROGRESS IN NEUROBIOLOGY

Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function

(2019) Eric W. Lumsden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex differences in response to ketamine as a rapidly acting intervention for treatment resistant depression

(2019) Marlene P. Freeman et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial

(2019) Jennifer L. Phillips et al.   AMERICAN JOURNAL OF PSYCHIATRY

Interaction of Sex and Age on the Dissociative Effects of Ketamine Action in Young Healthy Participants

(2019) B. Derntl et al.   Frontiers in Neuroscience

Ketamine-induced changes in plasma brain-derived neurotrophic factor (BDNF) levels are associated with the resting-state functional connectivity of the prefrontal cortex

(2019) Marie Woelfer et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Ketamine for Rapid Reduction of Suicidal Thoughts in Major Depression: A Midazolam-Controlled Randomized Clinical Trial

(2018) Michael F. Grunebaum et al.   AMERICAN JOURNAL OF PSYCHIATRY

Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression

(2018) Ming-Fen Ho et al.   BIOCHEMICAL PHARMACOLOGY

Optimising first- and second-line treatment strategies for untreated major depressive disorder — the SUN☺D study: a pragmatic, multi-centre, assessor-blinded randomised controlled trial

(2018) Tadashi Kato et al.   BMC Medicine

OUP accepted manuscript

(2018)   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Behavioral and biochemical sensitivity to low doses of ketamine: Influence of estrous cycle in C57BL/6 mice

(2018) Amanda M. Dossat et al.   NEUROPHARMACOLOGY

Disinhibition of CA1 pyramidal cells by low-dose ketamine and other antagonists with rapid antidepressant efficacy

(2018) Allie J. Widman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidemiology of Suicide and the Psychiatric Perspective

(2018) Silke Bachmann   International Journal of Environmental Research and Public Health

Epidemiology of Adult DSM-5 Major Depressive Disorder and Its Specifiers in the United States

(2018) Deborah S. Hasin et al.   JAMA Psychiatry

Brain-Derived Neurotrophic Factor and Major Depressive Disorder: Evidence from Meta-Analyses

(2018) Taro Kishi et al.   Frontiers in Psychiatry

Sex differences in the pharmacokinetics of low-dose ketamine in plasma and brain of male and female rats.

(2018) Samantha K Saland et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Spencer L James et al.   LANCET

Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2R,6R)-hydroxynorketamine

(2018) Kenichi Fukumoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex Differences in the Temporal Neuromolecular and Synaptogenic Effects of the Rapid-acting Antidepressant Drug Ketamine in the Mouse Brain

(2018) Connor Thelen et al.   NEUROSCIENCE

Factors Influencing the Cardiovascular Response to Subanesthetic Ketamine: A Randomized, Placebo-Controlled Trial

(2017) Thomas Liebe et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Effects of a ketamine metabolite on synaptic NMDAR function

(2017) Kanzo Suzuki et al.   NATURE

Locomotor sensitization to intermittent ketamine administration is associated with nucleus accumbens plasticity in male and female rats

(2017) C.E. Strong et al.   NEUROPHARMACOLOGY

Ketamine treatment involves medial prefrontal cortex serotonin to induce a rapid antidepressant-like activity in BALB/cJ mice

(2017) T.H. Pham et al.   NEUROPHARMACOLOGY

Sex- and dose-dependent abuse liability of repeated subanesthetic ketamine in rats

(2017) Kristin J. Schoepfer et al.   PHYSIOLOGY & BEHAVIOR

Gender differences in depression in representative national samples: Meta-analyses of diagnoses and symptoms.

(2017) Rachel H. Salk et al.   PSYCHOLOGICAL BULLETIN

Effects of ketamine on the unconditioned and conditioned locomotor activity of preadolescent and adolescent rats: impact of age, sex, and drug dose

(2017) Sanders A. McDougall et al.   PSYCHOPHARMACOLOGY

A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression

(2016) Jaskaran B. Singh et al.   AMERICAN JOURNAL OF PSYCHIATRY

Role of Cytochrome P4502B6 Polymorphisms in Ketamine Metabolism and Clearance

(2016) Lesley K. Rao et al.   ANESTHESIOLOGY

Ketamine augmentation for outpatients with treatment-resistant depression: Preliminary evidence for two-step intravenous dose escalation

(2016) Cristina Cusin et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Repeated ketamine treatment induces sex-specific behavioral and neurochemical effects in mice

(2016) Connor Thelen et al.   BEHAVIOURAL BRAIN RESEARCH

Sex Differences in Effects of Ketamine on Behavior, Spine Density, and Synaptic Proteins in Socially Isolated Rats

(2016) Ambalika Sarkar et al.   BIOLOGICAL PSYCHIATRY

Ketamine-dependent neuronal activation in healthy volunteers

(2016) Anna Höflich et al.   Brain Structure & Function

Suicide and suicidal behaviour

(2016) Gustavo Turecki et al.   LANCET

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

(2016) Ronald S Duman et al.   NATURE MEDICINE

Ketamine Treatment and Global Brain Connectivity in Major Depression

(2016) Chadi G Abdallah et al.   NEUROPSYCHOPHARMACOLOGY

Ketamine-induced changes in connectivity of functional brain networks in awake female nonhuman primates: a translational functional imaging model

(2016) Kaundinya Gopinath et al.   PSYCHOPHARMACOLOGY

Reinforcing properties of an intermittent, low dose of ketamine in rats: effects of sex and cycle

(2016) Katherine N. Wright et al.   PSYCHOPHARMACOLOGY

Effects of gender on ketamine-induced conditioned placed preference and urine metabonomics

(2016) Run Guo et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Hedonic sensitivity to low-dose ketamine is modulated by gonadal hormones in a sex-dependent manner

(2016) Samantha K. Saland et al.   Scientific Reports

The use of ketamine as an antidepressant: a systematic review and meta-analysis

(2015) Caoimhe M. Coyle et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Sex differences in the rapid and the sustained antidepressant-like effects of ketamine in stress-naïve and “depressed” mice exposed to chronic mild stress

(2015) A. Franceschelli et al.   NEUROSCIENCE

Gender and brain regions specific differences in brain derived neurotrophic factor protein levels of depressed individuals who died through suicide

(2015) Shawn Hayley et al.   NEUROSCIENCE LETTERS

Acute ketamine challenge increases resting state prefrontal-hippocampal connectivity in both humans and rats

(2015) Oliver Grimm et al.   PSYCHOPHARMACOLOGY

R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects

(2015) C Yang et al.   Translational Psychiatry

Raphe AMPA receptors and nicotinic acetylcholine receptors mediate ketamine-induced serotonin release in the rat prefrontal cortex

(2014) Naoya Nishitani et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

REDD1 is essential for stress-induced synaptic loss and depressive behavior

(2014) Kristie T Ota et al.   NATURE MEDICINE

Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression: A Two-Site Randomized Controlled Trial

(2013) James W. Murrough et al.   AMERICAN JOURNAL OF PSYCHIATRY

Sex, Gender, Genetics, and Health

(2013) Susan E. Short et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Disorder-specific volumetric brain difference in adolescent major depressive disorder and bipolar depression

(2013) Frank P. MacMaster et al.   Brain Imaging and Behavior

Ketamine Pharmacology: An Update (Pharmacodynamics and Molecular Aspects, Recent Findings)

(2013) Georges Mion et al.   CNS Neuroscience & Therapeutics

Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex

(2013) W. Zhou et al.   EUROPEAN PSYCHIATRY

Augmentation of response and remission to serial intravenous subanesthetic ketamine in treatment resistant depression

(2013) Paulo R. Shiroma et al.   JOURNAL OF AFFECTIVE DISORDERS

Sex differences in the antidepressant-like effects of ketamine

(2013) Nicole Carrier et al.   NEUROPHARMACOLOGY

Subanesthetic Doses of Ketamine Transiently Decrease Serotonin Transporter Activity: A PET Study in Conscious Monkeys

(2013) Shigeyuki Yamamoto et al.   NEUROPSYCHOPHARMACOLOGY

GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine

(2013) Rong-Jian Liu et al.   NEUROPSYCHOPHARMACOLOGY

R (−)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine

(2013) Ji-chun Zhang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Ketamine elicits sustained antidepressant-like activity via a serotonin-dependent mechanism

(2013) Valentina Gigliucci et al.   PSYCHOPHARMACOLOGY

Gender differences in abusers of amphetamine-type stimulants and ketamine in southwestern China

(2012) Yangyang Zhang et al.   ADDICTIVE BEHAVIORS

Estradiol induces cytochrome P450 2B6 expression at high concentrations: Implication in estrogen-mediated gene regulation in pregnancy

(2012) Kwi Hye Koh et al.   BIOCHEMICAL PHARMACOLOGY

Relationship of Ketamine's Plasma Metabolites with Response, Diagnosis, and Side Effects in Major Depression

(2012) Carlos A. Zarate et al.   BIOLOGICAL PSYCHIATRY

Synaptic Potentiation Is Critical for Rapid Antidepressant Response to Ketamine in Treatment-Resistant Major Depression

(2012) Brian R. Cornwell et al.   BIOLOGICAL PSYCHIATRY

The Role of Eukaryotic Elongation Factor 2 Kinase in Rapid Antidepressant Action of Ketamine

(2012) Lisa M. Monteggia et al.   BIOLOGICAL PSYCHIATRY

Antidepressant-like effects of low ketamine dose is associated with increased hippocampal AMPA/NMDA receptor density ratio in female Wistar–Kyoto rats

(2012) Y. Tizabi et al.   NEUROSCIENCE

Stereoselective and regiospecific hydroxylation of ketamine and norketamine

(2012) Zeruesenay Desta et al.   XENOBIOTICA

Treatment-resistant depression: therapeutic trends, challenges, and future directions

(2012) Al-harbi   Patient Preference and Adherence

Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression

(2011) Hiroyuki Koike et al.   BEHAVIOURAL BRAIN RESEARCH

Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

(2011) Nanxin Li et al.   BIOLOGICAL PSYCHIATRY

Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice

(2011) E Beurel et al.   MOLECULAR PSYCHIATRY

Grand challenges in global mental health

(2011) Pamela Y. Collins et al.   NATURE

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

(2011) Courtney S. Jernigan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The role of BDNF in depression on the basis of its location in the neural circuitry

(2010) Hui Yu et al.   ACTA PHARMACOLOGICA SINICA

A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression

(2010) Nancy Diazgranados et al.   ARCHIVES OF GENERAL PSYCHIATRY

Frontal white matter abnormalities following chronic ketamine use: a diffusion tensor imaging study

(2010) Y. Liao et al.   BRAIN

Enantioselective capillary electrophoresis for identification and characterization of human cytochrome P450 enzymes which metabolize ketamine and norketamine in vitro

(2010) Simone Portmann et al.   JOURNAL OF CHROMATOGRAPHY A

Rapid Resolution of Suicidal Ideation After a Single Infusion of anN-Methyl-D-Aspartate Antagonist in Patients With Treatment-Resistant Major Depressive Disorder

(2010) Nancy DiazGranados et al.   JOURNAL OF CLINICAL PSYCHIATRY

Inclusion of Women and Gender-Specific Analyses in Randomized Clinical Trials of Treatments for Depression

(2010) Andrea H. Weinberger et al.   JOURNAL OF WOMENS HEALTH

Prefrontal cortical abnormalities in currently depressed versus currently remitted patients with major depressive disorder

(2010) Giacomo Salvadore et al.   NEUROIMAGE

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Serum and plasma BDNF levels in major depression: A replication study and meta-analyses

(2010) Luisella Bocchio-Chiavetto et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

S(+)-ketamine Effect on Experimental Pain and Cardiac Output

(2009) Marnix Sigtermans et al.   ANESTHESIOLOGY

Effects of Intravenous Ketamine on Explicit and Implicit Measures of Suicidality in Treatment-Resistant Depression

(2009) Rebecca B. Price et al.   BIOLOGICAL PSYCHIATRY

Gender-Specific Impact of Brain-Derived Neurotrophic Factor Signaling on Stress-Induced Depression-Like Behavior

(2009) Anita E. Autry et al.   BIOLOGICAL PSYCHIATRY

Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression

(2009) Marije aan het Rot et al.   BIOLOGICAL PSYCHIATRY

Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes

(2009) D. J. Waxman et al.   MOLECULAR PHARMACOLOGY

Transcriptome Analysis of Synaptoneurosomes Identifies Neuroplasticity Genes Overexpressed in Incipient Alzheimer's Disease

(2009) Celia Williams et al.   PLoS One

Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats

(2009) Lêda S.B. Garcia et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

Glutamate and the Neural Basis of the Subjective Effects of Ketamine

(2008) J. F. William Deakin et al.   ARCHIVES OF GENERAL PSYCHIATRY

Chronic Administration of Ketamine Elicits Antidepressant-Like Effects in Rats without Affecting Hippocampal Brain-Derived Neurotrophic Factor Protein Levels

(2008) Lêda S. Garcia et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

A pooled analysis of two placebo-controlled trials of desvenlafaxine in major depressive disorder

(2008) Daniel Z. Lieberman et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

(2007) Sungho Maeng et al.   BIOLOGICAL PSYCHIATRY

Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus

(2007) Lêda S.B. Garcia et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY