Article
Nanoscience & Nanotechnology
Shuai Ren, Lina Song, Ying Tian, Li Zhu, Kai Guo, Huifeng Zhang, Zhongqiu Wang
Summary: A multifunctional theranostic nanoplatform Fe3O4-PEG-Cy7-EMO was successfully developed for the diagnosis and treatment of pancreatic cancer, showing potential application prospects. The platform exhibited good stability, imaging properties, and therapeutic effects, demonstrating excellent performance in in vitro and in vivo experiments.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Feixiang Hu, Dan Wang, Xiaowen Ma, Tingdan Hu, Yali Yue, Wei Tang, PuYe Wu, Tong Tong, Weijun Peng
Summary: The purpose of this study is to develop a T (2) MRI negative contrast agent with a controllable size and explore the feasibility of dual contrast enhancement by combining T (2) with CEST contrast agents. The study was conducted in vitro with HCT-116 human colon cancer cells. Fe3O4 nanoparticles (NPs) with a controllable size and no toxicity were successfully synthesized, and by combining them with a CEST contrast agent, the two contrast agents could be imaged simultaneously.
Article
Pharmacology & Pharmacy
Xuan-Hai Do, Tu Dac Nguyen, Thi Thu Huong Le, Thuy Thanh To, Thi Van Khanh Bui, Nam Hong Pham, Khanh Lam, Thi My Nhung Hoang, Phuong Thu Ha
Summary: This study evaluated the biological activity of nanoconjugates composed of superparamagnetic Fe3O4 nanoparticles coated with alginate and curcumin (Fe3O4/Cur@ALG) in cancer cells. The results showed that Fe3O4 nanoparticles had high biocompatibility and low toxicity in mice. Fe3O4/Cur@ALG enhanced the magnetic resonance imaging contrast and inhibited the growth of sarcoma 180 tumors through magnetic heating and the anticancer effects of curcumin.
Article
Biochemistry & Molecular Biology
Alexey A. Lipengolts, Yulia A. Finogenova, Vsevolod A. Skribitsky, Kristina E. Shpakova, Adi Anaki, Menachem Motiei, Alevtina S. Semkina, Maxim A. Abakumov, Anna V. Smirnova, Elena Y. Grigorieva, Rachela Popovtzer
Summary: In this study, core/shell Fe3O4@Au theranostic nanoparticles were developed with the aim of providing bimodal CT and MRI enhancement. These nanoparticles showed significant enhancement of tumors and tumor blood vessels and accumulated in the liver and spleen. They were found to be non-toxic and effective contrast agents for CT and MRI diagnostics, with potential applications in cancer diagnostics and beyond.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Huazhong Cai, Yanxia Chen, Liusheng Xu, Yingping Zou, Xiaoliang Zhou, Guoxin Liang, Dongqing Wang, Zhimin Tao
Summary: In this study, chemically synthetic polymer PBDFDTBO was coated with amphiphilic polymers PEO-PCL and DSPE-PEG to form stable fluorescent nanoparticles. Physicochemical properties of the nanoparticles were characterized, and in vitro and in vivo studies showed that the hydrophobic composition of the nanoparticles affected their biodistribution and tumor accumulation. Different coating strategies can impact the performance of nanoparticles in pancreatic cancer delivery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Sedigheh Cheraghali, Ghasem Dini, Isabella Caligiuri, Michele Back, Flavio Rizzolio
Summary: In this study, hierarchical MnZn ferrite nanoparticles were synthesized and their surface characteristics were improved by PEGylation. In vitro MRI studies confirmed the ability of the synthesized nanoparticles as a contrast agent. Results were compared with normal structured MnZn ferrite nanoparticles.
Article
Chemistry, Physical
Xiaoming Cao, Liyuan Gu, Shike Hu, Aiman Mukhtar, Kaiming Wu
Summary: A Fe/Mn multilayer nanowire with adjustable Fe layer as T-1-T-2 dual-modal contrast agents was synthesized, showing higher r(1) and r(2) values compared to single Fe or Mn nanowires. These findings suggest the potential use of Fe/Mn multilayer nanowires as MRI contrast agents in the future.
Article
Materials Science, Multidisciplinary
Amal Rezka Putra, Yoki Yulizar, Rien Ritawidya, Dewangga Oky Bagus Apriandanu, Sumandi Juliyanto, Ahsanal Fikri, Rizki Marcony Surya
Summary: By conjugating nimotuzumab with MnFe2O4 NPs and labeling it with iodine-131, we have successfully developed a multimodal MRI and SPECT nanoprobe with high imaging quality and radiochemical purity.
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Phan Quoc Thong, Le Thi Thu Huong, Nguyen Dac Tu, Hoang Thi My Nhung, Lam Khanh, Do Hung Manh, Pham Hong Nam, Nguyen Xuan Phuc, Javier Alonso, Ju Qiao, Srinivas Sridhar, Ha Phuong Thu, Manh Huong Phan, Nguyen Thi Kim Thanh
Summary: In this study, novel magnetic trifunctional nanoparticles were designed and fabricated. These nanoparticles can be used for drug release, MRI, and magnetic fluid hyperthermia. The results showed that these nanoparticles have good drug loading and release ability, as well as high specific absorption rate and enhanced MRI contrast. Animal experiments further confirmed the advantages of these nanoparticles in tumor observation and magnetic fluid hyperthermia. Conclusion: These nanocarriers have the potential for drug release, cancer treatment monitoring, and therapy.
Article
Chemistry, Multidisciplinary
Munawar Khalil, Ely Arina Haq, Astari Dwiranti, Eka Sunarwidhi Prasedya, Yoshitaka Kitamoto
Summary: This study reports on the synthesis of bifunctional nanocarriers that can accurately and targetedly deliver an anticancer drug. The surface functionalization of the nanocarriers had little effect on their physicochemical properties but significantly influenced drug loading and release efficiency. The conjugation of folic acid led to increased cytotoxicity of the drug-loaded nanocarriers.
Article
Nanoscience & Nanotechnology
Boddu Adilakshmi, Obireddy Sreekanth Reddy, Duddekunta Hemalatha, Kummari S. V. Krishna Rao, Wing-Fu Lai
Summary: Site-specific drug delivery systems using PEG as carriers have been widely adopted due to its favorable features. The development of carriers for hydrophobic anticancer agents remains a challenge. The developed drug conjugate PEGDA-MN-DOX shows anticancer potential, cancer-targeting ability, and ROS-generating capacity for effective drug encapsulation and sustained release in chemotherapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Songbo Zhao, Jiazhi Duan, Yalin Lou, Ruyun Gao, Shanshan Yang, Piming Wang, Chunhua Wang, Lin Han, Minghuan Li, Chunhong Ma, Xiaohong Liang, Hong Liu, Yuanhua Sang, Lifen Gao
Summary: A novel immunotherapy approach utilizing NK cells conjugated with magnetic nanoparticles has been developed for treating solid tumors, demonstrating improved tumor targeting and inhibition capabilities through magnetic field guidance.
Article
Chemistry, Analytical
Xudong Shi, Yulin Sun, Langtao Shen
Summary: In this study, we investigated the design and application of a PET/MRI dual-modal imaging agent based on superparamagnetic iron oxide nanoparticles (SPION). The α(v)β(3)-targeting RGD peptide and Cu-64 were conjugated onto SPION. Small animal PET and MR imaging in glioblastoma tumor-bearing mice showed that this dual-modal imaging contrast agent could potentially be used for PET/MRI dual-modal imaging for tumor diagnosis.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2022)
Article
Chemistry, Analytical
Trong-Nghia Le, Hsin-Yi Chen, Xuan Mai Lam, Chi-Chia Wang, Huan-Cheng Chang
Summary: Nanodiamonds (NDs) have been developed as in vitro diagnostic sensors for two complementary assays: particle-enhanced turbidimetric immunoassay (PETIA) and spin-enhanced lateral flow immunoassay (SELFIA). These NDs, with a largerefractiveindex, emit bright red fluorescence when excited by green light. In experiments using CRP as the target antigen, anti-CRP-conjugated NDs displayed high colloidal stability and low limits of detection.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Shengchao Wang, Guiqiang Qi, Zhichen Zhang, Qiangqiang Yin, Na Li, Zhongtao Li, Guangyue Shi, Haifeng Hu, Liguo Hao
Summary: In this study, a gadolinium-doped iron oxide nanocluster with T1-T2 dual-mode imaging and targeted therapy was synthesized using iron acetylacetone and gadolinium acetylacetone as raw materials. The results showed that the synthesized material could actively target pancreatic cancer cells and exhibit excellent magnetic resonance enhancement, indicating its potential applications for the precise diagnosis and efficient treatment of pancreatic cancer.