Article
Nanoscience & Nanotechnology
Ningning Song, Bo Li, Dandan Li, Yunwen Yan
Summary: In this study, a Zr-based metal-organic framework (MOF) modified with hyaluronic acid (HA) was developed for two-photon activated photodynamic therapy (PDT) in triple negative breast cancer (TNBC). The composite ZrTc@HA exhibited significant two-photon activity and excellent light-triggered reactive oxygen species generation ability. It can serve as a diagnostic probe for fluorescence imaging and a therapeutic agent for PDT, showing great potential for monotherapy and synergistic phototherapy in TNBC.
Article
Biochemistry & Molecular Biology
Shahrzad Zirak Hassan Kiadeh, Azadeh Ghaee, Mehdi Farokhi, Jhamak Nourmohammadi, Addie Bahi, Frank K. Ko
Summary: The study demonstrates that MOF-contained pectin nanofibers have potential application value in improving mechanical strength, antibacterial properties, as well as inducing angiogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Medicine, Research & Experimental
Qianqian Jiang, Mengmeng Zhang, Quanwei Sun, Dengke Yin, Zihua Xuan, Ye Yang
Summary: Porphyrin-based metal-organic framework (MOF) materials can serve as carriers for chemotherapy and photosensitizers in photodynamic therapy. Loading doxorubicin hydrochloride (DOX) in porphyrin MOFs can prolong DOX residence time in tumor tissues and promote DOX endocytosis by tumor cells. Adjuvant treatment with photodynamic therapy can resensitize breast cancer tumors to DOX and enhance the chemotherapy effect synergistically.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Applied
Parimal Pandit, Stuti Bhagat, Pranita Rananaware, Zinia Mohanta, Manoj Kumar, Vivek Tiwari, Sanjay Singh, Varsha P. Brahmkhatri
Summary: This study reports a novel strategy for the design and fabrication of an iron oxide nanoparticle encapsulated dual MOF composite, decorated with folic acid as a targeting agent and Quercetin as a drug payload. The resultant nanocomposites exhibited effective anticancer activities and targeted delivery in breast cancer cells, making them a potential theranostics agent for cancer therapy.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Yujie Zhao, Xian Jiang, Xu Liu, Xinyu Liu, Zhihui Liu, Xiaowei Liu
Summary: Metal-organic frameworks (MOFs) are hybrid porous crystalline materials composed of metal ions/clusters and organic linkers. They have diverse functionalities and have found wide applications in various research areas. Photo-responsive MOFs, in particular, have shown great potential in biological sensing and imaging, making them an ideal platform for cancer phototherapy. The high porosity and tunable pore sizes of MOFs allow for drug loading, further enhancing the effectiveness of anticancer treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Zhihong Bao, Kexin Li, Peipei Hou, Ru Xiao, Yue Yuan, Zhenhua Sun
Summary: Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), has gained significant attention for its high spatial selectivity and non-invasiveness. Nanoscale metal-organic frameworks (nMOFs) are ideal for biomedical applications, especially in cancer phototherapy, due to their unique characteristics.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Xiaosheng Bai, Yan Lin, Lingyi Gong, Junfeng Duan, Xiaoduan Sun, Changguang Wang, Zerong Liu, Jun Jiang, Xiangyu Zhou, Meiling Zhou, Zhirong Zhang, Zhongbing Liu, Pei Jing, Zhirong Zhong
Summary: Researchers have developed a novel nanoparticle system that inactivates the mitochondria of tumor cells to provide adequate local oxygen concentrations for photodynamic therapy. The nanoparticles solubilize the photosensitizer, prolong its circulation, and enhance its antitumor effects.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Nanoscience & Nanotechnology
Sainan Liu, Zhendong Liu, Qi Meng, Changxiao Chen, Maolin Pang
Summary: In this research, a cubic porphyrin-based COF named CTP with excellent hydrophilicity was prepared for the first time using a simple method. By linking the porphyrin monomer into the COF, solubility and biocompatibility issues were overcome, and the band gap was narrowed. The resulting CTP showed enhanced sonodynamic effect and photothermal conversion under external irradiation.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Inorganic & Nuclear
Ding-Yi Fu, Xiao Liu, Xiaohua Zheng, Mengjiao Zhou, Weiqi Wang, Gaoxing Su, Tianqing Liu, Lei Wang, Zhigang Xie
Summary: Metal-organic frameworks (MOFs) modified with biocompatible polymers have shown superior performance in terms of bioavailability, pharmacokinetics, and colloidal stability. This review summarizes typical synthetic procedures to obtain the polymer-MOF hybrids and provides an overview of their application in bioimaging and cancer therapy, emphasizing strategic hybridization of polymers and MOFs for enhanced therapeutic performance.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Inorganic & Nuclear
Danni Jin, Jianan Zhang, Youyou Huang, Xiru Qin, Jiayi Zhuang, Wujie Yin, Sijie Chen, Yang Wang, Ping Hua, Yong Yao
Summary: Gas therapy is a burgeoning and promising research field in biomedicine due to its high therapeutic efficacy and biocompatibility. Metal-organic frameworks (MOFs) show potential applications in delivering and releasing gas molecules. Recent developments focus on designing multifunctional MOF-based nanoplatforms for delivering and releasing therapeutic gas molecules against tumors.
DALTON TRANSACTIONS
(2021)
Review
Medicine, Research & Experimental
Jie Yang, Dihua Dai, Xi Zhang, Lesheng Teng, Lianjun Ma, Ying-Wei Yang
Summary: Cancer remains a severe threat to human health. The marriage of nanomaterials and therapeutic methods, especially metal-organic frameworks (MOFs), provides a practical possibility to improve the deficiencies in cancer therapy. MOFs have been widely applied in cancer therapy to overcome the drawbacks of other therapeutic methods through their controllable morphologies, tailorable diameters, diverse compositions, tunable porosities, high specific surface areas, facile functionalization, and good biocompatibility.
Article
Biotechnology & Applied Microbiology
Rong-Tian Li, Yi-Dan Zhu, Wen-Ya Li, Ying-Ke Hou, Yi-Ming Zou, Ying-Hua Zhao, Quan Zou, Wen-Hua Zhang, Jin-Xiang Chen
Summary: A multifunctional nanoplatform with core-shell structure was constructed for the synergistic treatment of breast cancer. This pH-dissociable platform can release drugs gradually in the acidic tumor microenvironment. The platform has shown remarkable anti-tumor activity.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Applied
Qiu-Lin Wen, Bi-Chao Wu, Zheng-Fen Pu, Rong Sheng Li, Jian Ling, Qiue Cao
Summary: This study reported a green-emitting fluorescent COF by integrating flexible building blocks and transforming it into nanoscale sheets, which reduced the aggregation-caused fluorescence quenching. It was found that the dispersed COF in different solvents showed different fluorescence properties, and the presence of folic acid in methanol solvent significantly and selectively induced a blue-shift of the COF fluorescence peak.
Article
Biotechnology & Applied Microbiology
Yiyang Cong, Bo Sun, Jianlun Hu, Xiaoyang Li, Yanan Wang, Jingyi Zhang, Dongzhi Yang, Weifei Lu, Zhi Ding, Xiaofeng Wang, Hao Hong
Summary: This study developed a metal-organic framework nanoplatform that can produce carbon monoxide in a controllable manner and adjust tumor microenvironment during cancer therapy, providing a new therapeutic strategy.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Analytical
Yujiao Sun, Xue Wang, Hao Zhang
Summary: An electrochemical sensor using silver nanowires doped with a zeolite-like metal-organic framework was developed for highly sensitive and stable determination of folic acid. The sensor exhibited linear response in the concentration range of folic acid and showed good performance in real samples.
Article
Pharmacology & Pharmacy
Xinyue Chang, Mingran Dong, Xiao Mi, Meigeng Hu, Juan Lu, Xi Chen
Summary: The present study found that Trichilia catigua A. Juss. extract (TCE) has a protective effect against di (2-ethylhexyl) phthalate (DEHP)-induced damage to the reproductive system of mice. TCE improved testicular histopathology, repaired testicular function, and reduced oxidative stress damage. Additionally, TCE exerted its protective effects by regulating the oxidation-related pathway and steroidogenic-related pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiao Mi, Juan Lu, Mingran Dong, Yang Lou, Xia Zhan, Xi Chen
Summary: Dihydromyricetin (DHM) holds potential as an antitumor agent, but its low bioavailability limits its clinical application. In this study, DHM@ZIF-8 nanoparticles were developed using ZIF-8 as a carrier to enhance its antitumor activity. The nanoparticles exhibited a regular morphology with a suitable particle size and a high drug release rate in a simulated tumor micro acid environment. Compared to the prodrug, DHM@ZIF-8 showed increased killing effect on HepG2 cells, along with enhanced removal of ROS, promotion of apoptosis, and significant modulation of apoptosis-related proteins within tumor cells.