Molecular Networking for Drug Toxicities Studies: The Case of Hydroxychloroquine in COVID-19 Patients

Nile Red fluorescence spectroscopy reports early physicochemical changes in myelin with high sensitivity

(2021) Wulin Teo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New psychoactive substance cocktail in an intensive care intoxication case elucidated by molecular networking

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The endosomal lipid bis(monoacylglycero) phosphate as a potential key player in the mechanism of action of chloroquine against SARS-COV-2 and other enveloped viruses hijacking the endocytic pathway

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Kidney disease is associated with in-hospital death of patients with COVID-19

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Liver injury during highly pathogenic human coronavirus infections

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Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

(2020) Jia Liu et al.   Cell Discovery

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(2020) Chao Zhang et al.   Lancet Gastroenterology & Hepatology

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Deploying Biomolecules as Anti-COVID-19 Agents

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Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: A retrospective analysis

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Higher frequency of hepatic steatosis at CT among COVID-19-positive patients

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Treatments in Covid-19 patients with pre-existing metabolic dysfunction-associated fatty liver disease: A potential threat for drug-induced liver injury?

(2020) Pierre-Jean Ferron et al.   BIOCHIMIE

Diet, Gut Microbiota and COVID-19

(2020) Praveen Rishi et al.   INDIAN JOURNAL OF MICROBIOLOGY

SARS-CoV-2 renal tropism associates with acute kidney injury

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Pharmacocinétique de l’hydroxychloroquine chez les patients COVID-19 en réanimation : étude de cohorte observationnelle

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COVID-19 prevention and treatment: A critical analysis of chloroquine and hydroxychloroquine clinical pharmacology

(2020) Nicholas J. White et al.   PLOS MEDICINE

Metabolism and Interactions of Chloroquine and Hydroxychloroquine with Human Cytochrome P450 Enzymes and Drug Transporters

(2020) Slobodan Rendic et al.   CURRENT DRUG METABOLISM

New insights into quetiapine metabolism using molecular networking

(2020) Brendan Le Daré et al.   Scientific Reports

A case of fatal acebutolol poisoning: an illustration of the potential of molecular networking

(2019) Brendan Le Daré et al.   INTERNATIONAL JOURNAL OF LEGAL MEDICINE

Mitochondria in non-alcoholic fatty liver disease

(2018) Inês C.M. Simões et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Simultaneous quantitation of hydroxychloroquine and its metabolites in mouse blood and tissues using LC–ESI–MS/MS: An application for pharmacokinetic studies

(2018) Yashpal S. Chhonker et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Hydroxychloroquine: A Physiologically-Based Pharmacokinetic Model in the Context of Cancer-Related Autophagy Modulation

(2018) Keagan P. Collins et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Drug-Induced Alterations of Mitochondrial DNA Homeostasis in Steatotic and Nonsteatotic HepaRG Cells

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Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyrene/Ethanol CoExposure

(2018) Simon Bucher et al.   Oxidative Medicine and Cellular Longevity

Application of a molecular networking approach for clinical and forensic toxicology exemplified in three cases involving 3-MeO-PCP, doxylamine, and chlormequat

(2018) Sophie Allard et al.   Drug Testing and Analysis

Bisphenol a induces steatosis in HepaRG cells using a model of perinatal exposure

(2016) Simon Bucher et al.   ENVIRONMENTAL TOXICOLOGY

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

(2016) Mingxun Wang et al.   NATURE BIOTECHNOLOGY

A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen

(2016) Anaïs Michaut et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

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(2013) Karima Begriche et al.   HEPATOLOGY

MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data

(2010) Tomáš Pluskal et al.   BMC BIOINFORMATICS

Pharmacokinetics of Hydroxychloroquine and Its Clinical Implications in Chemoprophylaxis against Malaria Caused by Plasmodium vivax

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Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1α involvement in CYP3A4 repression

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