JAK Inhibition Prevents DNA Damage and Apoptosis in Testicular Ischemia-Reperfusion Injury via Modulation of the ATM/ATR/Chk Pathway

Quercetin ameliorates testosterone secretion disorder by inhibiting endoplasmic reticulum stress through the miR-1306-5p/HSD17B7 axis in diabetic rats

(2021) Di Wang et al.   Bosnian Journal of Basic Medical Sciences

Protective effect of Berberine on reproductive function and spermatogenesis in diabetic rats via inhibition of ROS/JAK2/NFκB pathway

(2020) Jingyu Song et al.   Andrology

Inhibition of NADPH oxidase alleviates germ cell apoptosis and ER stress during testicular ischemia reperfusion injury

(2020) Farah Al-Saleh et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Biological Network Model of Effect of Chronic Intermittent Hypoxia on Spermatogenesis in Rats

(2020) Jisheng Wang et al.   MEDICAL SCIENCE MONITOR

STAT1-p53-p21axis-dependent stress-induced progression of chronic nephrosis in adriamycin-induced mouse model

(2020) Hua Wei et al.   Annals of Translational Medicine

Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2

(2019) Cheng Wang et al.   Nature Communications

Betulinic Acid Attenuates T-2-Toxin-Induced Testis Oxidative Damage Through Regulation of the JAK2/STAT3 Signaling Pathway in Mice

(2019) Jing Wu et al.   Biomolecules

Cellular cytokine receptor signaling and ATM pathway intersections affect hepatic DNA repair

(2019) Priya Gupta et al.   CYTOKINE

Epigallocatechin-3-gallate modulates germ cell apoptosis through the SAFE/Nrf2 signaling pathway

(2019) May Al-Maghrebi et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

ATR is required to complete meiotic recombination in mice

(2018) Sarai Pacheco et al.   Nature Communications

DNA mismatch repair and the DNA damage response

(2016) Zhongdao Li et al.   DNA REPAIR

Testicular torsion-detorsion and potential therapeutic treatments: A possible role for ischemic postconditioning

(2016) Shogo Shimizu et al.   INTERNATIONAL JOURNAL OF UROLOGY

Correlative study on the JAK-STAT/PSMβ3 signal transduction pathway in asthenozoospermia

(2016) Junguo Li et al.   Experimental and Therapeutic Medicine

Oxidative stress at low levels can induce clustered DNA lesions leading to NHEJ mediated mutations

(2016) Vyom Sharma et al.   Oncotarget

ATM and ATR signaling at a glance

(2015) P. Awasthi et al.   JOURNAL OF CELL SCIENCE

Study on the role of JAK/STAT signaling pathway during chicken spermatogonial stem cells generation based on RNA-Seq

(2015) Lei ZHANG et al.   Journal of Integrative Agriculture

The ATM Signaling Cascade Promotes Recombination-Dependent Pachytene Arrest in Mouse Spermatocytes

(2015) Sarai Pacheco et al.   PLoS Genetics

Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

(2014) Shan Yan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Characterizing semen parameters and their association with reactive oxygen species in infertile men

(2014) Ashok Agarwal et al.   Reproductive Biology and Endocrinology

Sperm DNA damage caused by oxidative stress: modifiable clinical, lifestyle and nutritional factors in male infertility

(2014) C. Wright et al.   REPRODUCTIVE BIOMEDICINE ONLINE

ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing

(2013) H. Royo et al.   GENES & DEVELOPMENT

Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the JAK/STAT signaling activation

(2013) Yanna Si et al.   Journal of Translational Medicine

The source and significance of DNA damage in human spermatozoa; a commentary on diagnostic strategies and straw man fallacies

(2013) R. J. Aitken et al.   MOLECULAR HUMAN REPRODUCTION

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

The JAK-STAT Transcriptional Regulator, STAT-5, Activates the ATM DNA Damage Pathway to Induce HPV 31 Genome Amplification upon Epithelial Differentiation

(2013) Shiyuan Hong et al.   PLoS Pathogens

Activation of AMP-activated protein kinase in cerebella of Atm−/− mice is attributable to accumulation of reactive oxygen species

(2012) Xianghong Kuang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ISCHEMIC POSTCONDITIONING DURING REPERFUSION ATTENUATES INTESTINAL INJURY AND MUCOSAL CELL APOPTOSIS BY INHIBITING JAK/STAT SIGNALING ACTIVATION

(2012) Shi-Hong Wen et al.   SHOCK

Reactive Oxygen Species Scavenger Inhibits STAT3 Activation After Transient Focal Cerebral Ischemia–Reperfusion Injury in Rats

(2011) Chong Lei et al.   ANESTHESIA AND ANALGESIA

Mediators of the JAK/STAT Signaling Pathway in Human Spermatozoa1

(2011) Catherine Lachance et al.   BIOLOGY OF REPRODUCTION

Analysis of the relationships between oxidative stress, DNA damage and sperm vitality in a patient population: development of diagnostic criteria

(2010) R. J. Aitken et al.   HUMAN REPRODUCTION

STAT3 modulates the DNA damage response pathway

(2010) Seán P. Barry et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

The blockade of Janus kinase-2 (JAK2) signaling ameliorates mouse liver damage due to ischemia and reperfusion

(2010) Maria Cecilia S. Freitas et al.   LIVER TRANSPLANTATION

Postischemic poly (ADP-ribose) polymerase (PARP) inhibition reduces ischemia reperfusion injury in a hind-limb ischemia model

(2010) Robert S. Crawford et al.   SURGERY

Spermiogenesis and DNA Repair: A Possible Etiology of Human Infertility and Genetic Disorders

(2009) Frédéric Leduc et al.   Systems Biology in Reproductive Medicine

Interaction between PARP-1 and ATR in mouse fibroblasts is blocked by PARP inhibition

(2008) Padmini S. Kedar et al.   DNA REPAIR

Oxidative Stress: A Common Factor in Testicular Dysfunction

(2008) T. T. Turner et al.   JOURNAL OF ANDROLOGY