Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/ijms23010485
Keywords
endometrial microbiota; microbiome; reproductive tract microbiota; uterus; reproductive outcomes; infertility; assisted reproductive technologies; human reproduction
Funding
- Generalitat Valenciana, Spain [GRISOLIAP/2021/176]
- FIS project from the Instituto de Salud Carlos III (ISCIII), Spain [PI21/00235]
- Spanish Government MINECO/FEDER [RTI2018-094946-B-I00]
- Valencian Innovation Council [PROMETEO/2018/161]
- European Union [874867]
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Changes in the female genital tract microbiome are related to gynecological and obstetrical pathologies, but the influence of endometrial bacterial communities on human reproduction is still debated. Understanding the impact of microbiome on fertility allows personalized treatment and improves clinical outcomes.
Changes in the female genital tract microbiome are consistently correlated to gynecological and obstetrical pathologies, and tract dysbiosis can impact reproductive outcomes during fertility treatment. Nonetheless, a consensus regarding the physiological microbiome core inside the uterine cavity has not been reached due to a myriad of study limitations, such as sample size and experimental design variations, and the influence of endometrial bacterial communities on human reproduction remains debated. Understanding the healthy endometrial microbiota and how changes in its composition affect fertility would potentially allow personalized treatment through microbiome management during assisted reproductive therapies, ultimately leading to improvement of clinical outcomes. Here, we review current knowledge regarding the uterine microbiota and how it relates to human conception.
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