Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/ijms23010539
Keywords
bioprinting; hydrogel; xanthan gum; gelatin; biocompatibility
Funding
- Health Sciences Department research fund
- Universita del Piemonte Orientale
- Department of Science and Technology Innovation
- Universita del Piemonte Orientale
- [10126]
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In this study, a crosslinked 3D printable hydrogel based on gelatin and xanthan gum was developed for use as a scaffold for cell growth and as a wound dressing. These hydrogels showed different porosity and degradation time and exhibited biocompatibility.
In recent years, bioprinting has attracted much attention as a potential tool for generating complex 3D biological constructs capable of mimicking the native tissue microenvironment and promoting physiologically relevant cell-cell and cell-matrix interactions. The aim of the present study was to develop a crosslinked 3D printable hydrogel based on biocompatible natural polymers, gelatin and xanthan gum at different percentages to be used both as a scaffold for cell growth and as a wound dressing. The CellInk Inkredible 3D printer was used for the 3D printing of hydrogels, and a glutaraldehyde solution was tested for the crosslinking process. We were able to obtain two kinds of printable hydrogels with different porosity, swelling and degradation time. Subsequently, the printed hydrogels were characterized from the point of view of biocompatibility. Our results showed that gelatin/xanthan-gum bioprinted hydrogels were biocompatible materials, as they allowed both human keratinocyte and fibroblast in vitro growth for 14 days. These two bioprintable hydrogels could be also used as a helpful dressing material.
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