Article
Oncology
Michelle Xin Liu, Kent-Man Chu
Summary: This study aims to investigate the functional roles of miR-410-3p in primary gastric cancer and the roles of exosomes in regulating miR-410-3p expression. It was found that miR-410-3p was downregulated in gastric cancer and its overexpression inhibited cancer cell proliferation, migration, and invasion. Exosomal miR-410-3p expression was significantly higher than its endogenous expression and exosomes from gastric cancer cells regulated miR-410-3p expression in other cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Immunology
Rachel E. Crossland, Jean Norden, Sakhila Ghimire, Mateja Kralj Juric, Kim F. Pearce, Clare Lendrem, Matthew Collin, Eva Mischak-Weissinger, Ernst Holler, Hildegard T. Greinix, Anne M. Dickinson
Summary: The study found that miR-155 and miR-146a were upregulated in gastrointestinal and skin tissue samples of aGvHD patients, and their expression levels in serum and urine samples were also associated with the risk of developing aGvHD. These results support the potential of miR-155 and miR-146a as biomarkers for aGvHD, but further investigation is needed to understand their role in generalized inflammation and specific pathophysiology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Qi Chen, Hao Li, Yusi Liu, Min Zhao
Summary: This study comprehensively analyzed the epigenetic regulation in rheumatoid arthritis (RA) using differential analysis and cross-analysis. The results identified differentially methylated sites, differentially expressed genes, and differentially expressed miRNAs associated with RA. A comprehensive epigenetic regulatory network was constructed, and core regulatory genes were identified. This study provides a new direction for future research on the epigenetic mechanisms of RA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Bo Yang, Ruicheng Yang, Bojie Xu, Jiyang Fu, Xinyi Qu, Liang Li, Menghong Dai, Chen Tan, Huanchun Chen, Xiangru Wang
Summary: E. coli infection induced upregulation of miR-155 and miR-146a in astrocytes, which modulated bacteria-triggered neuroinflammatory responses through negative feedback regulation involving the TLR-mediated NF-kappa B and EGFR-NF-kappa B signaling pathways, thus protecting the central nervous system from further neuroinflammatory damage.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Medicine, General & Internal
Chia-Chun Tseng, Yuan-Zhao Lin, Chia-Hui Lin, Daw-Yang Hwang, Ruei-Nian Li, Wen-Chan Tsai, Tsan-Teng Ou, Cheng-Chin Wu, Yu-Chih Lin, Wan-Yu Sung, Kuan-Yu Chen, Shun-Jen Chang, Jeng-Hsien Yen
Summary: This study found that CREM hypomethylation and upregulation occur in rheumatoid arthritis (RA), and CREM variants are associated with the development of serositis and lymphadenopathy in RA.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, General & Internal
Olfat G. Shaker, Omayma O. Abdelaleem, Nermeen A. Fouad, Naglaa A. Ahmed, Hoda A. Hussein, Enas G. Ibrahem, Abdelrahmaan A. Mohamed, Othman M. Ahmed, Doaa Y. Ali
Summary: This study found that miR-146a (rs2910164) and miR-155 (rs767649) gene polymorphisms are closely related to the development of BD in the Egyptian population and also influence disease severity.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Oncology
Neda K. Dezfuli, Shamila D. Alipoor, Neda Dalil Roofchayee, Sharareh Seyfi, Babak Salimi, Ian M. Adcock, Esmaeil Mortaz
Summary: The study found that miR-146a expression was significantly downregulated in NSCLC patients, while IL-6 and TGF-beta levels were elevated. The frequencies of immune cells CD3+ CTLA-4+ and Treg cells were also higher in patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Zahra Mahmoudi, Negin Karamali, Seyed Askar Roghani, Shirin Assar, Mehran Pournazari, Parviz Soufivand, Farhad Salari, Alireza Rezaiemanesh
Summary: The study investigated the gene expression levels of MALAT1, H19, miR-199a-5p, and miR-1-3p in RA patients. MALAT1 and H19 may serve as potential biomarkers for distinguishing RA patients from controls.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Genetics & Heredity
Nisha Nair, Anne Barton, Anthony G. Wilson
Summary: The review highlights the key epigenetic modifications in different cell types associated with rheumatoid arthritis and discusses potential therapeutic targets focusing on epigenetic markers. It emphasizes the importance of altered epigenetic regulation in promoting the destructive behavior underlying disease pathogenesis.
Article
Biotechnology & Applied Microbiology
Guizhi Jia, Chunguang Liang, Wenhui Li, Hongliang Dai
Summary: miR-410-3p plays an important role in cardiovascular disease development, and this study revealed its role and mechanism in Ang II-induced cardiac hypertrophy by targeting inhibition of Smad7.
Article
Neurosciences
Chu-Chiao Tseng, Shao-Cheng Wang, Yi-Chien Yang, Hung-Chun Fu, Chen-Kai Chou, Hong-Yo Kang, Yi-Yung Hung
Summary: Activated toll-like receptor (TLR) signaling has been well investigated in major depressive disorder (MDD) and several factors including TNFAIP3, TLR4, TNIP2, miR-146a, and miR-155 have been found to play important roles in this pathway. Aberrant histone modification, particularly H3K4me3, has also been implicated in psychiatric disorders. This study aimed to explore the H3K4me3 levels in the promoters of these factors in MDD patients and its changes after antidepressant treatment. The results showed significantly lower H3K4me3 levels in the promoters of TNFAIP3, TLR4, TNIP2, miR-146a, and miR-155 in MDD patients compared to healthy controls. These levels did not significantly change after antidepressant treatment, and there were correlations between H3K4me3 levels in TNIP2 and TLR4 promoters and depression severity.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Paulina Kober, Beata Joanna Mossakowska, Natalia Rusetska, Szymon Baluszek, Emilia Grecka, Ryszard Konopinski, Ewa Matyja, Artur Ozieblo, Tomasz Mandat, Mateusz Bujko
Summary: This study reveals the involvement of MIR193B gene hypermethylation in the pathogenesis of meningiomas, leading to downregulation of two miRNAs and subsequent inhibition of meningioma cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rosa Curcio, Giulia Poli, Consuelo Fabi, Chiara Sugoni, Maria Bruna Pasticci, Roberto Ferranti, Monica Rossi, Ilenia Folletti, Leandro Sanesi, Edoardo Santoni, Irene Dominioni, Massimiliano Cavallo, Giovanni Morgana, Lorenzo Mordeglia, Giovanni Luca, Giacomo Pucci, Stefano Brancorsini, Gaetano Vaudo
Summary: We investigated the association between circulating microRNAs and fibrosis development in COVID-19-related ARDS survivors. miR-17-5p, miR-223-3p, and miR-146a-5p were significantly down-regulated in patients with fibrosis-like lesions. Our results support the hypothesis that NLRP3-Inflammasome could be implicated in the process of fibrotic evolution of COVID-19-associated ARDS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yi-Yung Hung, Chen-Kai Chou, Yi-Chien Yang, Hung-Chun Fu, El-Wui Loh, Hong-Yo Kang
Summary: This study found that in patients with major depressive disorder, the expression levels of miR-146a in exosomes were higher, and patients who achieved remission showed lower levels of various microRNAs before treatment and increased levels after treatment. Let-7e, miR-145, and miR-146a showed acceptable discrimination between the remission and non-remission groups.
Article
Immunology
Tahereh Donyavi, Farah Bokharaei-Salim, Hossein Bannazadeh Baghi, Khadijeh Khanaliha, Mahrokh Alaei Janat-Makan, Bahareh Karimi, Javid Sadri Nahand, Hamed Mirzaei, AliReza Khatami, Saba Garshasbi, Majid Khoshmirsafa, Seyed Jalal Kiani
Summary: This study aimed to identify specific miRNA profiles that can be used as biomarkers to differentiate acute COVID-19 cases, healthy individuals, and those in the post-acute phase. The results showed that miR-29a-3p, miR-146a-3p, and let-7b-3p were significantly elevated in COVID-19 patients compared to healthy individuals, with potential for high sensitivity and specificity in COVID-19 diagnosis and monitoring. MiR-29a-3p and miR-146a-3p also showed promise as biomarkers for distinguishing acute from post-acute phases of COVID-19.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Gregorie Lebeau, Franck Ah-Pine, Matthieu Daniel, Yosra Bedoui, Damien Vagner, Etienne Frumence, Philippe Gasque
Summary: Mesenchymal stem cells (MSCs) play a critical role in response to infection and can remove cell debris, regulate immune activities, control pathogens, and contribute to tissue remodeling. However, chronic infection and inflammation can affect the functions and immune regulatory activities of MSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Anne-Laure Sandenon Seteyen, Emmanuelle Girard-Valenciennes, Axelle Septembre-Malaterre, Philippe Gasque, Pascale Guiraud, Jimmy Selambarom
Summary: This review discusses the immunomodulatory effects of alkaloids on arthritogenic alphavirus infection and inflammation. The study found that alkaloids can interfere with key cellular components and signaling pathways, inhibiting viral infection and inflammation.
Review
Biochemistry & Molecular Biology
Matthieu Daniel, Yosra Bedoui, Damien Vagner, Loic Raffray, Franck Ah-Pine, Berenice Doray, Philippe Gasque
Summary: The treatment of sepsis and septic shock remains a major public health issue. Mesenchymal stem cells (MSCs) are emerging as a potential approach for cell therapy in sepsis, but the mechanisms underlying their beneficial effects are still unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Axelle Septembre-Malaterre, Chailas Boina, Audrey Douanier, Philippe Gasque
Summary: Fibrosis is a chronic progressive and incurable disease. Metformin, a widely used antidiabetic drug, has been recognized for its potential antifibrotic effects. This study found that metformin can reduce the expression of key factors involved in fibrosis and has the ability to control the differentiation of mesenchymal stem cells. These findings suggest that metformin could be a candidate molecule for the treatment of fibrosis.
Article
Cell Biology
Yosra Bedoui, Dauriane De Larichaudy, Matthieu Daniel, Franck Ah-Pine, Jimmy Selambarom, Pascale Guiraud, Philippe Gasque
Summary: Old world alphaviruses, such as chikungunya, can cause severe arthralgia/arthritis. However, they can also lead to atypical neurological manifestations, including acute inflammatory Guillain-Barre syndrome (GBS). This study explored the role of Schwann cells (SC) in GBS following alphavirus infection. The researchers found that SC expressed the alphavirus receptor MxRA8, allowing viral entry and replication. Additionally, they observed immune responses and changes in gene expression in infected SC, providing new insights into the pathogenesis of GBS.
Article
Biochemistry & Molecular Biology
Melissa Payet, Franck Ah-Pine, Xavier Guillot, Philippe Gasque
Summary: CD248 belongs to a glycoprotein family and its expression can be regulated in response to IL1- beta and PMA treatment, resulting in the formation of soluble CD248 (sCD248). Furthermore, inflammatory MSCs express CD248 abundantly and shed it in response to cytokines and pro-angiogenic growth factors, suggesting its potential involvement in the pathogenesis of RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Jolimar Hanna, Franck Ah-Pine, Chailas Boina, Yosra Bedoui, Philippe Gasque, Axelle Septembre-Malaterre
Summary: The study investigated the effects of C3a anaphylatoxin on tumor cells and the tumor microenvironment. It found that C3a plays a crucial role in the tumor microenvironment by modulating the expression of cytokines, chemokines, Cox-2, HO-1, and upregulating the oxidative stress response. C3a also regulates VEGF expression, suggesting a role in angiogenesis.
