Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/ijms23010480
Keywords
diabetes; microbiota; therapy
Funding
- Minister of Science and Higher Education in the Regional Initiative of Excellence program [002/RID/2018/19]
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This review summarizes the role of gut microbiota in healthy individuals and the changes in bacterial composition associated with the development of diabetes. It also presents new developments in diabetes therapy based on influencing the gut microbiota as a promising method to alter the course of the disease. Furthermore, it highlights the lack of data and suggests future directions for research to establish the causal relationship between dysbiosis and diabetes.
Diabetes mellitus is a significant clinical and therapeutic problem because it can lead to serious long-term complications. Its pathogenesis is not fully understood, but there are indications that dysbiosis can play a role in the development of diabetes, or that it appears during the course of the disease. Changes in microbiota composition are observed in both type 1 diabetes (T1D) and type 2 diabetes (T2D) patients. These modifications are associated with pro-inflammation, increased intestinal permeability, endotoxemia, impaired beta-cell function and development of insulin resistance. This review summarizes the role of the gut microbiota in healthy individuals and the changes in bacterial composition that can be associated with T1D or T2D. It also presents new developments in diabetes therapy based on influencing the gut microbiota as a promising method to alter the course of diabetes. Moreover, it highlights the lacking data and suggests future directions needed to prove the causal relationship between dysbiosis and diabetes, both T1D and T2D.
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