Phase Separation and Mechanical Forces in Regulating Asymmetric Cell Division of Neural Stem Cells

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

(2021) Simon Alberti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

In vivo reconstitution finds multivalent RNA-RNA interactions as drivers of mesh-like condensates

(2021) Weirui Ma et al.   eLife

Phase Separation in Cell Polarity

(2021) Heyang Wei et al.   BIOCHEMISTRY

A Conserved PDZ-Binding Motif in aPKC Interacts with Par-3 and Mediates Cortical Polarity

(2020) Ryan W. Holly et al.   CURRENT BIOLOGY

Liquid-liquid phase separation drives skin barrier formation

(2020) Felipe Garcia Quiroz et al.   SCIENCE

Par complex cluster formation mediated by phase separation

(2020) Ziheng Liu et al.   Nature Communications

Phase Separation in Membrane Biology: The Interplay between Membrane-Bound Organelles and Membraneless Condensates

(2020) Yan G. Zhao et al.   DEVELOPMENTAL CELL

Liquid-Liquid Phase Separation in Neuronal Development and Synaptic Signaling

(2020) Xiandeng Wu et al.   DEVELOPMENTAL CELL

RNA contributions to the form and function of biomolecular condensates

(2020) Christine Roden et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases

(2020) Hong Zhang et al.   Science China-Life Sciences

Phase Separation in Cell Division

(2020) Joseph Y. Ong et al.   MOLECULAR CELL

Phase Separation as a Missing Mechanism for Interpretation of Disease Mutations

(2020) Brian Tsang et al.   CELL

Mechanical regulation of cell size, fate, and behavior during asymmetric cell division

(2020) Melissa K. Delgado et al.   CURRENT OPINION IN CELL BIOLOGY

Phase Separation, Transition, and Autophagic Degradation of Proteins in Development and Pathogenesis

(2019) Zheng Wang et al.   TRENDS IN CELL BIOLOGY

Division orientation: disentangling shape and mechanical forces

(2019) Tara M. Finegan et al.   CELL CYCLE

Asymmetric recruitment and actin-dependent cortical flows drive the neuroblast polarity cycle

(2019) Chet Huan Oon et al.   eLife

Reconstruction of Par-dependent polarity in apolar cells reveals a dynamic process of cortical polarization

(2019) Kalyn Kono et al.   eLife

Phase Separation in Asymmetric Cell Division

(2019) Wenyu Wen   BIOCHEMISTRY

Cell division and tissue mechanics

(2019) Benoit G Godard et al.   CURRENT OPINION IN CELL BIOLOGY

Mitotic Implantation of the Transcription Factor Prospero via Phase Separation Drives Terminal Neuronal Differentiation

(2019) Xiaodan Liu et al.   DEVELOPMENTAL CELL

Tau protein liquid–liquid phase separation can initiate tau aggregation

(2018) Susanne Wegmann et al.   EMBO JOURNAL

mRNA structure determines specificity of a polyQ-driven phase separation

(2018) Erin M. Langdon et al.   SCIENCE

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division

(2018) Zelin Shan et al.   Nature Communications

Emerging mechanisms of asymmetric stem cell division

(2018) Zsolt G. Venkei et al.   JOURNAL OF CELL BIOLOGY

Converging pathways in neurodegeneration, from genetics to mechanisms

(2018) Li Gan et al.   NATURE NEUROSCIENCE

Protein Complex Assemblies in Epithelial Cell Polarity and Asymmetric Cell Division

(2017) Wenyu Wen et al.   JOURNAL OF MOLECULAR BIOLOGY

RNA phase transitions in repeat expansion disorders

(2017) Ankur Jain et al.   NATURE

Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization

(2017) Shyi-Chyi Wang et al.   NATURE CELL BIOLOGY

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Liquid behavior of cross-linked actin bundles

(2017) Kimberly L. Weirich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatio-temporally separated cortical flows and spindle geometry establish physical asymmetry in fly neural stem cells

(2017) Chantal Roubinet et al.   Nature Communications

Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex

(2017) Martijn Gloerich et al.   Nature Communications

Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase

(2017) Amayra Hernández-Vega et al.   Cell Reports

Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity

(2016) Menglong Zeng et al.   CELL

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

aPKC Inhibition by Par3 CR3 Flanking Regions Controls Substrate Access and Underpins Apical-Junctional Polarization

(2016) Erika V. Soriano et al.   DEVELOPMENTAL CELL

Remodeling the zonula adherens in response to tension and the role of afadin in this response

(2016) Wangsun Choi et al.   JOURNAL OF CELL BIOLOGY

Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation

(2016) Manuel Carminati et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation

(2016) Manuel Carminati et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Phase Transition of Spindle-Associated Protein Regulate Spindle Apparatus Assembly

(2015) Hao Jiang et al.   CELL

The Hippo Pathway Core Cassette Regulates Asymmetric Cell Division

(2015) Alyona Keder et al.   CURRENT BIOLOGY

Warts Phosphorylates Mud to Promote Pins-Mediated Mitotic Spindle Orientation in Drosophila , Independent of Yorkie

(2015) Evan B. Dewey et al.   CURRENT BIOLOGY

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division

(2015) Min Jia et al.   Nature Communications

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Mitotic spindle (DIS)orientation and DISease: Cause or consequence?

(2012) Anna Noatynska et al.   JOURNAL OF CELL BIOLOGY

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Canoe binds RanGTP to promote PinsTPR/Mud-mediated spindle orientation

(2011) Brett Wee et al.   JOURNAL OF CELL BIOLOGY

Asymmetric cortical extension shifts cleavage furrow position in Drosophila neuroblasts

(2011) Marisa Connell et al.   MOLECULAR BIOLOGY OF THE CELL

LGN/mInsc and LGN/NuMA Complex Structures Suggest Distinct Functions in Asymmetric Cell Division for the Par3/mInsc/LGN and Gαi/LGN/NuMA Pathways

(2011) Jinwei Zhu et al.   MOLECULAR CELL

aPKC Phosphorylation of Bazooka Defines the Apical/Lateral Border in Drosophila Epithelial Cells

(2010) Eurico Morais-de-Sá et al.   CELL

Anisotropies in cortical tension reveal the physical basis of polarizing cortical flows

(2010) Mirjam Mayer et al.   NATURE

A spindle-independent cleavage furrow positioning pathway

(2010) Clemens Cabernard et al.   NATURE

Asymmetric cell division: recent developments and their implications for tumour biology

(2010) Juergen A. Knoblich   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polarized Myosin Produces Unequal-Size Daughters During Asymmetric Cell Division

(2010) Guangshuo Ou et al.   SCIENCE

aPKC Phosphorylates Miranda to Polarize Fate Determinants during Neuroblast Asymmetric Cell Division

(2009) Scott X. Atwood et al.   CURRENT BIOLOGY

Linking Cell Cycle to Asymmetric Division: Aurora-A Phosphorylates the Par Complex to Regulate Numb Localization

(2008) Frederik Wirtz-Peitz et al.   CELL

Mechanisms of Asymmetric Stem Cell Division

(2008) Juergen A. Knoblich   CELL

The PDZ Protein Canoe Regulates the Asymmetric Division of Drosophila Neuroblasts and Muscle Progenitors

(2008) Stephan Speicher et al.   CURRENT BIOLOGY

Mechanisms of asymmetric cell division: flies and worms pave the way

(2008) Pierre Gönczy   NATURE REVIEWS MOLECULAR CELL BIOLOGY