Article
Plant Sciences
Shuzhen Luo, Chunliu Pan, Songying Liu, Guoting Liao, Ailing Li, Yalun Wang, Aiqin Wang, Dong Xiao, Long-Fei He, Jie Zhan
Summary: Aluminum toxicity in acidic soil is a common problem that leads to decreased crop yields. Programmed cell death (PCD) is an important mechanism in the plant response to aluminum toxicity. The plant cell wall of crop roots, particularly hemicellulose 1 (HC1), is the primary target of aluminum. The activity of xyloglucan endotransglucosylase (XET), specifically regulated by the transcription of AhXTH32, plays a crucial role in this process.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Chunliu Pan, Xia Li, Shaochang Yao, Shuzhen Luo, Songying Liu, Aiqin Wang, Dong Xiao, Jie Zhan, Longfei He
Summary: Nitric oxide-mediated S-nitrosation through GSNOR plays important roles in cellular processes and signaling in plants, but the regulatory mechanism of programmed cell death by S-nitrosation is unclear. This study investigated the S-nitrosated proteomic and functions of GSNOR during Al-induced PCD in peanut. Al stress increased SNO content and GSNOR activity, with a significant positive correlation between SNO content and hydrogen peroxide content. S-nitrosated proteins were involved in regulating various biological processes, and the activity of GSNOR was inhibited by S-nitrosation.
Review
Plant Sciences
Yukun Wang, Hong Ye, Jianfang Bai, Fei Ren
Summary: Developmentally programmed cell death plays a vital role in regulating floral organ growth and development, involving factors such as tapetal degeneration, pollen tube rupture, receptive synergid cell death, nucellar degradation, and antipodal cell degradation. Understanding the complex molecular networks involved in floral dPCD processes provides insights into flower-specific dPCD process.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Genetics & Heredity
Dong Xiao, Xia Li, Yun-Yi Zhou, Li Wei, Chanthaphoone Keovongkod, Huyi He, Jie Zhan, Ai-Qin Wang, Long-Fei He
Summary: The study identified key pathways and genes associated with aluminum stress in peanuts, showing that rapid transcriptomic response helps activate effective aluminum tolerance mechanisms, MAPK signal transduction plays important roles in early response to aluminum stress in peanuts, and there is a link between ethylene signaling transduction and aluminum resistance-related genes in peanuts.
Article
Plant Sciences
Guoting Liao, Shuzhen Luo, Xinyue Li, Ailing Li, Yunchuan Mo, Aiqin Wang, Dong Xiao, Long-Fei He, Jie Zhan
Summary: This study found that AhRPN1a-like interacts directly with AhMC1 in peanut, and promotes aluminum-induced programmed cell death (PCD) through the 26S proteasome pathway, thereby reducing peanut's resistance to aluminum.
JOURNAL OF PLANT PHYSIOLOGY
(2023)
Review
Immunology
Shubai Zhong, Yuanqin Yin
Summary: Sepsis is a severe syndrome with high incidence and mortality that occurs when the immune system overreacts to an infection, leading to multiple organ dysfunction. Immunosuppression plays a crucial role in the clinical treatment and prognosis of sepsis. Recent studies have highlighted the involvement of the programmed cell death 1 signaling pathway in the development of immunosuppression in sepsis. This review systematically presents the mechanisms of immune dysregulation in sepsis, discusses the expression and regulatory effects of the programmed cell death 1 signaling pathway on immune cells associated with sepsis, and explores the current research developments and prospects for using this pathway in immunomodulatory therapy for sepsis. The review also identifies remaining questions and future research directions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Environmental
Ruyi Qian, Hongcheng Zhao, Xin Liang, Nan Sun, Nan Zhang, Xianyong Lin, Chengliang Sun
Summary: In this study, we investigated the relationship between autophagy and programmed cell death (PCD) in wheat roots under indium stress. Our results suggest that autophagy suppresses indium-induced PCD in wheat roots.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Medicine, General & Internal
Yan Zhang, Xinghua Lv, Feng Chen, Qian Fan, Yongqiang Liu, Zhanhai Wan, Janvier Nibaruta, Jipeng Lv, Xuena Han, Lin Wu, Hao Wang, Yufang Leng
Summary: MicroRNAs play a crucial role in regulating gene expression in kidney development and disease. Dysregulation of miRNAs can lead to various renal diseases. Understanding the mechanisms by which miRNAs regulate renal development and diseases is important for developing new diagnostic and therapeutic approaches, but more research is needed to fully understand these mechanisms.
Article
Plant Sciences
Yi Wu, Fangbin Cao, Lupeng Xie, Feibo Wu, Shenlong Zhu, Chengwei Qiu
Summary: Aluminum toxicity is a major constraint to crop production in acidic soils. This study investigated the changes in miRNA expression in the roots of two olive genotypes with contrasting aluminum tolerance. A total of 352 miRNAs were discovered, and 11 miRNAs showed significantly different expression patterns between the tolerant and sensitive genotypes under aluminum stress. In silico prediction identified potential target genes involved in transcriptional regulation, hormone signaling, transportation, and metabolism. These findings provide new insights into the regulatory roles of miRNAs in enhancing aluminum tolerance in olives.
Review
Cell Biology
Liuhua Zhou, Jiateng Sun, Lingfeng Gu, Sibo Wang, Tongtong Yang, Tianwen Wei, Tiankai Shan, Hao Wang, Liansheng Wang
Summary: Abnormalities in programmed cell death signaling cascades play a crucial role in the development and progression of cardiovascular diseases, leading to excessive cardiac remodeling and heart failure. Timely activation of cell death pathways post-injury can help in repairing cardiac structure and function. Drugs targeting key players in cell death signaling pathways may hold potential for future therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Chunbao Zhang, Fuyou Fu, Chunjing Lin, Xiaoyang Ding, Jingyong Zhang, Hao Yan, Pengnian Wang, Wei Zhang, Bao Peng, Limei Zhao
Summary: Cytoplasmic male sterility (CMS) is an important plant characteristic for exploiting heterosis in crop breeding. In this study, high-throughput sequencing and degradome analyses were utilized to identify miRNAs and their targets in a soybean CMS line. A comprehensive overview of reproductive development was provided, revealing potential roles of miRNAs in the CMS regulatory network.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Dachao Tang, Cheng Han, Shaofeng Lin, Xiaodan Tan, Weizhi Zhang, Di Peng, Chenwei Wang, Yu Xue
Summary: This study provides a comprehensive database for programmed cell death (iPCD), consisting of annotations for regulatory proteins involved in various PCD forms across different eukaryotic species. The database integrates information from multiple resources and covers a wide range of aspects, making it a valuable tool for further analysis of PCD in eukaryotes.
Article
Biochemistry & Molecular Biology
Adrian Zajac, Joanna Sumorek-Wiadro, Ewa Langner, Iwona Wertel, Aleksandra Maciejczyk, Bozena Pawlikowska-Pawlega, Jaroslaw Pawelec, Magdalena Wasiak, Monika Hulas-Stasiak, Dorota Badziul, Wojciech Rzeski, Michal Reichert, Joanna Jakubowicz-Gil
Summary: Inhibition of the PI3K/Akt/mTOR pathway sensitizes glioma cells to apoptosis with temozolomide treatment, while Hsp27 increases resistance to cell death. Different cell lines showed varying responses to LY294002 and temozolomide treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Rory Burke, Aideen McCabe, Neetu Ramesh Sonawane, Meet Hasmukh Rathod, Conor V. Whelan, Paul F. McCabe, Joanna Kacprzyk
Summary: Programmed cell death (PCD) is a genetically controlled process that eliminates redundant, damaged, or infected cells. This study used RNA sequencing and Arabidopsis thaliana suspension cells to identify PCD-associated genes and infer regulatory networks of PCD in plants.
Article
Plant Sciences
Zhengmei Yang, Tingting Dong, Xibin Dai, Yiliang Wei, Yujie Fang, Lei Zhang, Mingku Zhu, Ghazala Nawaz, Qinghe Cao, Tao Xu
Summary: This study identified and compared miRNAs in sweetpotato cultivars with different salt sensitivity, and found differentially expressed miRNAs and salt-responsive miRNAs. The target genes of these miRNAs were mainly transcription factors and proteins related to metabolism and stress response. These findings contribute to understanding the regulatory pattern of miRNAs in different sweetpotato genotypes and provide references for improving the agronomic traits of sweetpotato through miRNA manipulation.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
X. Li, G. J. Su, A. Ntambiyukuri, B. Tong, J. Zhan, A. Q. Wang, D. Xiao, L. F. He
Summary: Thioredoxins (Trx) are small multifunctional redox proteins that play important roles in various processes in plants. In this study, the Trx gene family was systematically identified and characterized in peanut. The basic properties, phylogenetic relationship, gene structure, chromosomal localization, and promoter prediction of AhTrx genes were analyzed. The expression patterns of AhTrx genes under different Al treatment times in two peanut cultivars were also investigated. The results provide potential candidate genes for further studying the effects and regulatory mechanisms of Trx genes under Al stress in peanut.
BIOLOGIA PLANTARUM
(2022)
Article
Plant Sciences
RuoLan Huang, Dong Xiao, Xin Wang, Jie Zhan, AiQing Wang, LongFei He
Summary: The study identified 126 LEA genes in the peanut genome through genome-wide analysis, divided into eight groups. Segmental duplication played a critical role in the amplification of AhLEAs, with most genes expressed in the late stages of peanut embryonic development. AhLEAs were involved in response to various abiotic stresses, regulated by hormones, and demonstrated enhanced tolerance to cold, aluminum, and drought stresses in yeast.
Article
Biochemistry & Molecular Biology
Xinlu Huang, Xiaoxi Huang, Lijun Guo, Longfei He, Dong Xiao, Jie Zhan, Aiqin Wang, Renfan Liang
Summary: This study compares the transcriptomic profiles of two Pueraria varieties in response to pseudo-rust disease. The results reveal differences in their gene expression patterns and suggest the involvement of transcription factors and metabolic pathways in the interaction between Pueraria and pathogens. The findings expand our understanding of Pueraria resistance and physiological regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Yunyi Zhou, Yuting Li, Jinmei Huang, Ruirong Jiao, Mei Li, Dong Xiao, Jie Zhan, Aiqin Wang, Longfei He
Summary: This study reveals the important role of DoDELLA1 in regulating yam tuber development and transgenic tobacco growth by modulating the expression of GA metabolism-related genes.
PLANT GROWTH REGULATION
(2022)
Article
Biotechnology & Applied Microbiology
Zhaoqin Cai, Zhipeng Cai, Jingli Huang, Aiqin Wang, Aaron Ntambiyukuri, Bimei Chen, Ganghui Zheng, Huifeng Li, Yongmei Huang, Jie Zhan, Dong Xiao, Longfei He
Summary: This study identified differentially expressed genes (DEGs) in fibrous and tuberous roots of two sweet potato varieties, and found that certain signaling pathways and metabolic processes are associated with tuberous root development. A hypothetical model of the genetic regulatory network for tuberous root development in sweet potato was proposed. These findings provide new insights into the molecular mechanism of tuberous root development in sweet potato.
Article
Biochemistry & Molecular Biology
Zhaoxia Guo, Yuanyuan Mei, Dan Wang, Dong Xiao, Xianglin Tang, Yaru Gong, Xinxin Xu, Ning Ning Wang
Summary: Reversible protein phosphorylation mediated by protein kinases and phosphatases is important in the regulation of leaf senescence. AtSARK, a positive regulator of senescence, is autophosphorylated on multiple serine/threonine and tyrosine residues. SSPP, a negative regulator, dephosphorylates the cytoplasmic domain of AtSARK. Mass spectrometry analysis revealed 27 autophosphorylation residues of AtSARK, and six of them were found to be important for its biological functions. Autophosphorylation of AtSARK is essential for its ability to promote leaf senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Min Zhou, Jin Luo, Dong Xiao, Aiqin Wang, Longfei He, Jie Zhan
Summary: This study developed a pollen tube-mediated Agrobacterium tumefaciens transformation method and successfully transformed the AhBI-1 gene into peanut. It was found that overexpression of the AhBI-1 gene enhanced root and shoot growth in peanut.
PLANT CELL TISSUE AND ORGAN CULTURE
(2023)
Article
Biology
Aaron Ntambiyukuri, Xia Li, Dong Xiao, Aiqin Wang, Jie Zhan, Longfei He
Summary: Peanut is an important oil crop, especially in the southern part of China. However, the acidic soil in this region inhibits plant growth and development. This study investigates the effect of photoperiod and aluminum (Al) stress on programmed cell death (PCD) in peanut plants. The findings demonstrate that photoperiod and Al stress play a role in cell death and the production of reactive oxygen species (ROS).
Article
Plant Sciences
Shuzhen Luo, Chunliu Pan, Songying Liu, Guoting Liao, Ailing Li, Yalun Wang, Aiqin Wang, Dong Xiao, Long-Fei He, Jie Zhan
Summary: Aluminum toxicity in acidic soil is a common problem that leads to decreased crop yields. Programmed cell death (PCD) is an important mechanism in the plant response to aluminum toxicity. The plant cell wall of crop roots, particularly hemicellulose 1 (HC1), is the primary target of aluminum. The activity of xyloglucan endotransglucosylase (XET), specifically regulated by the transcription of AhXTH32, plays a crucial role in this process.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
