Expression and Functionality of Connexin-Based Channels in Human Liver Cancer Cell Lines

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Gene expression profiles of liver cancer cell lines reveal two hepatocyte-like and fibroblast-like clusters

(2021) Keita Fukuyama et al.   PLoS One

Cholestasis Differentially Affects Liver Connexins

(2020) Axelle Cooreman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response

(2019) Stefano Caruso et al.   GASTROENTEROLOGY

Cx32 exerts anti-apoptotic and pro-tumor effects via the epidermal growth factor receptor pathway in hepatocellular carcinoma

(2019) Yuke Xiang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Connexin 32 downregulation is critical for chemoresistance in oxaliplatin-resistant HCC cells associated with EMT

(2019) Yan Yang et al.   Cancer Management and Research

Hepatocellular Carcinoma: Molecular Mechanisms and Targeted Therapies

(2019) Alqahtani et al.   Medicina-Lithuania

Gap Junction Intercellular Communication in the Carcinogenesis Hallmarks: Is This a Phenomenon or Epiphenomenon?

(2019) Zefferino et al.   Cells

Connexin 43 SUMOylation improves gap junction functions between liver cancer stem cells and enhances their sensitivity to HSVtk/GCV

(2018) Yimeng Shen et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

(2018) Mark A. Febbraio et al.   Cell Metabolism

Connexin and pannexin (hemi)channels: emerging targets in the treatment of liver disease

(2018) Axelle Cooreman et al.   HEPATOLOGY

Gap junctions in liver disease: Implications for pathogenesis and therapy

(2018) Manuel Hernández-Guerra et al.   JOURNAL OF HEPATOLOGY

Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis

(2017) Daniela Sia et al.   GASTROENTEROLOGY

A validated, transitional and translational porcine model of hepatocellular carcinoma

(2017) Kyle M. Schachtschneider et al.   Oncotarget

Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice

(2017) Joost Willebrords et al.   Scientific Reports

Altered Cell to Cell Communication, Autophagy and Mitochondrial Dysfunction in a Model of Hepatocellular Carcinoma: Potential Protective Effects of Curcumin and Stem Cell Therapy

(2016) Ola M Tork et al.   Asian Pacific Journal of Cancer Prevention

Human Hepatic HepaRG Cells Maintain an Organotypic Phenotype with High Intrinsic CYP450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical and Therapeutic Applications

(2016) Leonard J. Nelson et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Involvement of connexin43 in acetaminophen-induced liver injury

(2016) Michaël Maes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Structure, Regulation and Function of Gap Junctions in Liver

(2015) Joost Willebrords et al.   CELL COMMUNICATION AND ADHESION

Impaired gap junctions in human hepatocellular carcinoma limit intrinsic oxaliplatin chemosensitivity: A key role of connexin 26

(2015) YAN YANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Transformation of primary human hepatocytes in hepatocellular carcinoma

(2015) MAURO MONTALBANO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Connexin and pannexin signaling in gastrointestinal and liver disease

(2015) Michaël Maes et al.   Translational Research

Connexin 32 dysfunction promotes ethanol-related hepatocarcinogenesis via activation of Dusp1-Erk axis

(2015) Hiroyuki Kato et al.   Oncotarget

Connexin32 regulates hepatoma cell metastasis and proliferation via the p53 and Akt pathways

(2015) Bixing Zhao et al.   Oncotarget

Combined use of N-acetylcysteine and Liberase improves the viability and metabolic function of human hepatocytes isolated from human liver

(2014) David C. Bartlett et al.   CYTOTHERAPY

Evaluating Strategies to Normalise Biological Replicates of Western Blot Data

(2014) Andrea Degasperi et al.   PLoS One

Hepatoma SK Hep-1 Cells Exhibit Characteristics of Oncogenic Mesenchymal Stem Cells with Highly Metastatic Capacity

(2014) Jong Ryeol Eun et al.   PLoS One

Possible role of hemichannels in cancer

(2014) Kurt A. Schalper et al.   Frontiers in Physiology

Connexin and pannexin (hemi)channels in the liver

(2014) Michaël Maes et al.   Frontiers in Physiology

Connexin-dependent gap junction enhancement is involved in the synergistic effect of sorafenib and all-trans retinoic acid on HCC growth inhibition

(2013) YAN YANG et al.   ONCOLOGY REPORTS

Silencing of connexin 43 suppresses invasion, migration and lung metastasis of rat hepatocellular carcinoma cells

(2012) Kumiko Ogawa et al.   CANCER SCIENCE

Analysis of Four Connexin26 Mutant Gap Junctions and Hemichannels Reveals Variations in Hexamer Stability

(2010) Cinzia Ambrosi et al.   BIOPHYSICAL JOURNAL

Models of Hepatocellular Carcinoma and Biomarker Strategy

(2010) Cedo M. Bagi et al.   Cancers

Pharmacological “cross-inhibition” of connexin hemichannels and swelling activated anion channels

(2008) Zu-Cheng Ye et al.   GLIA