Review
Biochemistry & Molecular Biology
Yukang Liu, Chaofei Li, Zhangbin Feng, Biao Han, Deng-Guang Yu, Ke Wang
Summary: This article briefly reviews the pathogenesis and commonly used dressings of chronic diabetic wounds, and emphasizes on the advantages of electrospun nanofibers in the treatment of diabetic wounds. It also summarizes the reports of different types of nanofiber dressings on diabetic wounds. The article highlights the method of using multi-drug combination therapy in diabetic wounds, providing new ideas for the effective treatment of diabetic wounds.
Article
Chemistry, Multidisciplinary
Hongyu Lv, Meng Zhao, Yiran Li, Kun Li, Shaojuan Chen, Wenwen Zhao, Shaohua Wu, Yantao Han
Summary: This study developed a novel nanofibrous dressing for the treatment of hard-to-heal diabetic wounds. The dressing exhibited multiple biological functions, including anti-inflammation, antioxidation, pro-angiogenesis, and hemostasis.
Article
Instruments & Instrumentation
Marwah Suliman Maashi, Shatha G. Felemban, Hibah Ali Almasmoum, Mostafa Jarahian
Summary: The current study developed a biopolymer-based wound dressing loaded with Nicaraven, which showed potential in treating diabetic wounds. In vitro experiments demonstrated that the dressing was non-toxic to cells and protected them from oxidative stress. Animal studies revealed that the collagen dressings containing 4% and 6% Nicaraven exhibited better wound healing effects. Gene expression analysis also indicated that the dressings could modulate the expression levels of multiple genes. Overall, collagen dressings incorporated with 4% and 6% Nicaraven could be considered as a promising option for treating diabetic wounds in clinical settings.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yingzheng Zhao, Lantian Huang, Gaolong Lin, Mengqi Tong, Yilin Xie, Hanxiao Pan, Jianxun Shangguan, Qing Yao, Shihao Xu, Helin Xu
Summary: In this study, a three-layered skin-adaptive dressing was designed for the treatment of diabetic wounds. The dressing, made of different materials, showed flexibility and strong adhesive force. It could release anti-inflammatory and growth factors to promote wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Multidisciplinary
Yufan Zhu, Wei Zhou, Jieyu Xiang, Minhao Wu, Zhe Chen, Zhiqiang Yang, Renxiong Wei, Lin Cai
Summary: In this study, a Janus bilayer electrospun dressing was developed using modified electro-spinning technologies. The dressing consists of a hydrophilic outer layer loaded with deferoxamine (DFO) and a hydrophobic inner layer with mesh-like structure. The Janus dressing showed good biocompatibility and facilitated biofluid drainage, while promoting angiogenesis.
MATERIALS & DESIGN
(2023)
Article
Chemistry, Applied
Yuanping Hao, Wenwen Zhao, Hao Zhang, Weiping Zheng, Qihui Zhou
Summary: The BP/CS-bFGF hydrogel dressing prepared in this study shows great potential for diabetic chronic wound management. It has strong wet-tissue adhesion, self-mending, and antibacterial properties, and displays fast hemostasis capacity. The hydrogel dressing significantly accelerates full-thickness diabetic wound repair by increasing the production of Ki67, promoting the generation of epithelialization and collagen, inducing the formation of hair follicles, and enhancing neovascularization.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Tianci Zhang, Zehong Xiang, Lei Liu, Zhifang Ma, Mikhail Panteleev, Fazly I. Ataullakhanov, Qiang Shi
Summary: Platelet-anchored electrospun meshes are developed to modulate inflammation and accelerate the healing of diabetic wounds. The anchored platelets enhance macrophage recruitment and control the release of thymosin beta 4 to promote the polarization of macrophages. The inflammatory regulation promotes angiogenesis and accelerates diabetic wounds healing.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Yi Li, Hangqi Luo, Yue Li, Peipei Huang, Jie Xu, Jian Zhang, Peihan Cai, Huacheng He, Jiang Wu, Xiaokun Li
Summary: Functional degradable sutures with controlled release of basic fibroblast growth factor (bFGF) were developed to enhance wound healing. The suture showed prolonged bFGF release, improved cell adhesion and proliferation, accelerated wound closure, and facilitated skin mechanical restoration.
MATERIALS & DESIGN
(2023)
Article
Chemistry, Applied
Mahnaz Sadat Mirbagheri, Sahar Akhavan-Mahdavi, Anwarul Hasan, Mohammad Saeed Kharazmi, Seid Mahdi Jafari
Summary: Healing diabetic foot ulcers (DFUs) has been a major challenge in the medical field. The type of dressing used plays a crucial role in wound healing, infection prevention, and scar formation. Utilizing nanofiber (NF) wound dressings, which have suitable surface topography and structure, can effectively reduce scarring and accelerate the healing process for DFUs. Chitosan (CS), a widely recognized biopolymer, has unique properties that make it suitable for biomedical applications, such as tissue engineering and drug delivery systems. This study aims to review relevant works on CS-based NFs to enhance DFU treatment, considering its hemostatic and antimicrobial effects.
CARBOHYDRATE POLYMERS
(2023)
Article
Materials Science, Paper & Wood
Changming Tan, Zhaoshun Yuan, Feng Xu, Xia Xie
Summary: A Pramipexole-loaded wound dressing was produced via electrospinning of cellulose acetate solution. The dressing with 3% Pramipexole concentration showed higher cell viability and improved wound healing potential in a rat model of diabetic wound.
Review
Instruments & Instrumentation
Divya Pamu, Vyshnavi Tallapaneni, Veera Venkata Satyanarayana Reddy Karri, Sachin Kumar Singh
Summary: Diabetes mellitus is a complex disease affecting millions worldwide, with diabetic wound being a common complication. Early detection, debridement, offloading, and infection control are crucial for diabetic wound treatment. Nanofiber dressings are considered a promising innovative approach, offering high moisture absorption, oxygen exchange rate, and antibacterial properties.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Anna Yusuf Aliyu, Oluwatoyin A. Adeleke
Summary: Chronic wounds in poorly managed diabetics are difficult to heal due to long-term uncontrolled blood glucose levels. To prevent complications, special medical care is needed. Nanofibrous scaffolds are a promising treatment due to their flexibility, ability to load bioactive compounds, and biomimetic environment for cell proliferation.
Review
Biochemistry & Molecular Biology
Mohit Kumar, Ayah. R. Hilles, Yi Ge, Amit Bhatia, Syed Mahmood
Summary: The current treatment strategies for diabetic wound care are not very effective, leading to a demand for new and improved therapeutic techniques. Nanomaterials like polymeric nanofibers (NFs) offer a promising approach for the treatment of diabetic wounds and have emerged as viable options for wound management. Electrospinning is a powerful and cost-effective method to fabricate versatile NFs with a wide array of raw materials for different biological applications. The electrospun NFs have unique advantages in the development of wound dressings and accelerate wound healing due to their high specific surface area and porosity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Endocrinology & Metabolism
Shen-Yuan Zheng, Xin-Xing Wan, Piniel Alphayo Kambey, Yan Luo, Xi-Min Hu, Yi-Fan Liu, Jia-Qi Shan, Yu-Wei Chen, Kun Xiong
Summary: Wounds in diabetic patients, especially diabetic foot ulcers, are difficult to heal and can lead to amputation. Common treatments are ineffective and growth factors play a crucial role in regulating diabetic wound healing. Modulating different growth factors can significantly improve diabetic wound treatment and some current treatments have shown promising results by targeting specific growth factors.
WORLD JOURNAL OF DIABETES
(2023)
Article
Nanoscience & Nanotechnology
Shan He, Huangding Wen, Nannan Yao, Lu Wang, Junqun Huang, Zhiqing Li
Summary: The composite nano-sustained release system, TTO-NL@PCS, has potential for accelerating the healing of diabetic and MRSA-infected wounds. It disperses biofilms and kills MRSA through the stable and slow release of tea tree oil. Additionally, it improves inflammatory response and wound healing.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Medicine, General & Internal
Qi Zhang, Jianan Hu, Lijiao Wei, Ri Cao, Ruishu Ma, Huimin Song, Yi Jin
Review
Integrative & Complementary Medicine
Qi Zhang, Jianan Hu, Lijiao Wei, Yibo Jia, Yi Jin
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2019)
Review
Integrative & Complementary Medicine
Qi Zhang, Xia Yang, Huimin Song, Yi Jin
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2020)
Article
Dermatology
Qi Zhang, Ke Zhang, Yuxin Wang, Yibo Jia, Jiaxin Gu, Xintong Li, Mingzi Li
Summary: The study successfully translated the attitude measurement tool C-APrIAD for the prevention of incontinence-associated dermatitis into Chinese and verified its reliability and validity among Chinese nurses. Results showed that C-APrIAD demonstrated good internal consistency and structural validity, with a high correlation with the General Self-Efficacy Scale.
JOURNAL OF TISSUE VIABILITY
(2021)
Article
Geriatrics & Gerontology
Jiaxin Gu, Chaojuan Yang, Ke Zhang, Qi Zhang
Summary: This study investigated the connection between social support and treatment burden among older COPD patients, with psychological capital playing a mediating role. The findings showed that both social support and psychological capital significantly impact treatment burden, providing a new perspective for medical professionals in managing treatment burden.
Review
Nursing
Huijing Zhang, Qi Zhang, Dan Luo, Xue Cai, Ruxue Li, Yating Zhang, Yanhui Lu, Jiajia Liu, Jiaxin Gu, Mingzi Li
Summary: This review of 23 studies involving 3,114 participants found that family-based intervention can significantly improve glycosylated haemoglobin levels, body mass index, blood pressure, fasting glucose, and other health-related outcomes for adults with diabetes. Subgroup analyses suggested that family-based intervention in Asian regions is particularly effective in improving glycosylated haemoglobin levels. Further studies are recommended to explore the effectiveness of combining family theory with family-based interventions for family members of individuals with diabetes.
JOURNAL OF CLINICAL NURSING
(2022)
Review
Health Care Sciences & Services
Qi Zhang, Yu Fu, Yanhui Lu, Yating Zhang, Qifang Huang, Yajie Yang, Ke Zhang, Mingzi Li
Summary: The meta-analysis revealed that VR-based therapies are effective in improving executive function, memory, and visuospatial function in stroke patients. However, further research is needed to determine the impact on global cognitive function, attention, verbal fluency, depression, and quality of life.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Review
Health Care Sciences & Services
Jingsong Luo, Ke Zhang, Yaxin Xu, Yanmin Tao, Qi Zhang
Summary: With the development of flexible electronics and chip technology, wearable device-based intervention shows promise in improving glycemic control in patients with type 2 diabetes (T2D). A meta-analysis of 6 studies involving 1001 patients found that wearable device-based intervention may be more effective than usual care in glycemic control. Subgroup analysis suggests that the intervention is particularly effective when the duration is 12 weeks or less and when wearable devices have goal-setting or encouragement functions.
JOURNAL OF MEDICAL SYSTEMS
(2022)
Review
Nursing
Yajie Yang, Sitian Li, Ying Cai, Qi Zhang, Pu Ge, Shaomei Shang, Hongbin Han
Summary: This study evaluated the effectiveness of telehealth-based exercise intervention on pain, physical function, and quality of life in patients with knee osteoarthritis. The systematic review and meta-analysis showed that telehealth-based exercise interventions significantly reduced pain in knee osteoarthritis patients and had similar effects to controls in terms of physical function and quality of life.
JOURNAL OF CLINICAL NURSING
(2022)
Article
Clinical Neurology
Yuanyuan Jiang, Yelin Jiang, Tiantian Peng, Mengyue Wang, Manman Li, Min Zhang, Li Li, Qi Zhang
Summary: This study aimed to test the reliability and validity of the Chinese version of the Parkinson Anxiety Scale (C-PAS) in Chinese patients with PD, and confirmed its three-factor structure with 12 items. The results showed that the C-PAS has demonstrated good psychometric properties and can be used to evaluate anxiety in patients with PD.
Review
Rehabilitation
Yanmin Tao, Jingsong Luo, Jing Tian, Sihan Peng, Hongyan Wang, Jun Cao, Zhifei Wen, Xiangeng Zhang
Summary: Robot-assisted rehabilitation significantly improves lower limb motor function and fatigue in Parkinson's disease patients, but its effect on upper limb function remains inconclusive.
DISABILITY AND REHABILITATION
(2023)
Article
Primary Health Care
Qi Zhang, Ke Zhang, Miao Li, Jiaxin Gu, Xintong Li, Mingzi Li, Yi Jin
Summary: The Mandarin version of the Treatment Burden Questionnaire (TBQ) was found to have acceptable validity and reliability among stroke patients. By measuring treatment burden, it can help allocate health resources more effectively and provide tailored therapeutic interventions for stroke survivors.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
