Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 188, Issue -, Pages 52-61Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.08.013
Keywords
SIRT1; microRNAs; Aging; Age-associated diseases
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SIRT1 plays a crucial role in regulating cell processes such as growth, inflammation, metabolism, survival, and aging, while miRNAs function in modulating cell functions, tumor suppression, cell death, and aging. The interaction between SIRT1 and miRNAs may provide new insights into age-associated diseases and aging-related molecular pathways.
Sirtuin-1 (SIRT1) as a NAD + -dependent Class III protein deacetylase, involves in longevity and various cellular physiological processes. SIRT1 via deacetylating transcription factors regulates cell growth, inflammation, metabolism, hypoxic responses, cell survival, senescence, and aging. MicroRNAs (miRNAs) are short non-coding RNAs that modulate the expression of target genes in a post-transcriptional manner. Recent investigations have exhibited that miRNAs have an important role in regulating cell growth, development, stress responses, tumor formation and suppression, cell death, and aging. In the present review, we summarize recent findings about the roles of miRNAs in regulating SIRT1 and SIRT1-associated signaling cascade and downstream effects, like apoptosis and aging. Here we introduce and discuss how activity and expression of SIRT1 are modulated by miRNAs and further review the therapeutic potential of targeting miRNAs for age-associated diseases that involve SIRT1 dysfunction. Although at its infancy, research on the roles of miRNAs in aging and their function through modulating SIRT1 may provide new insights in deciphering the key molecular pathways related to aging and age-associated disorders.
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