E484K and N501Y SARS-CoV 2 spike mutants Increase ACE2 recognition but reduce affinity for neutralizing antibody

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

(2021) Emma C. Thomson et al.   CELL

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine induced sera

(2021) Daming Zhou et al.   CELL

Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization

(2021) Zhuoming Liu et al.   Cell Host & Microbe

Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies

(2021) Allison J. Greaney et al.   Cell Host & Microbe

The SARS-CoV-2 Y453F mink variant displays a pronounced increase in ACE-2 affinity but does not challenge antibody neutralization

(2021) Rafael Bayarri-Olmos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SARS-CoV-2 genomics: An Indian perspective on sequencing viral variants

(2021) Surabhi Srivastava et al.   JOURNAL OF BIOSCIENCES

Nanoluciferase complementation-based bioreporter reveals the importance of N-linked glycosylation of SARS-CoV-2 S for viral entry

(2021) Taha Azad et al.   MOLECULAR THERAPY

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

(2021) Zijun Wang et al.   NATURE

Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies

(2021) Rita E. Chen et al.   NATURE MEDICINE

Serine 477 plays a crucial role in the interaction of the SARS-CoV-2 spike protein with the human receptor ACE2

(2021) Amit Singh et al.   Scientific Reports

The basis of a more contagious 501Y.V1 variant of SARS-CoV-2

(2021) Haolin Liu et al.   CELL RESEARCH

Enhanced binding of the N501Y‐mutated SARS‐CoV‐2 spike protein to the human ACE2 receptor: insights from molecular dynamics simulations

(2021) Binquan Luan et al.   FEBS LETTERS

Vaccine-escape and fast-growing mutations in the United Kingdom, the United States, Singapore, Spain, India, and other COVID-19-devastated countries

(2021) Rui Wang et al.   GENOMICS

Higher infectivity of the SARS‐CoV‐2 new variants is associated with K417N/T, E484K, and N501Y mutants: An insight from structural data

(2021) Abbas Khan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Structural modeling of the SARS-CoV-2 Spike/human ACE2 complex interface can identify high-affinity variants associated with increased transmissibility

(2021) Hin Hark Gan et al.   JOURNAL OF MOLECULAR BIOLOGY

Neutralising antibody escape of SARS‐CoV‐2 spike protein: Risk assessment for antibody‐based Covid‐19 therapeutics and vaccines

(2021) Daniele Focosi et al.   REVIEWS IN MEDICAL VIROLOGY

Neutralizing Antibody Therapeutics for COVID-19

(2021) Aeron C. Hurt et al.   Viruses-Basel

SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity

(2021) Chihiro Motozono et al.   Cell Host & Microbe

Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species

(2021) Ruoke Wang et al.   IMMUNITY

Receptor binding, immune escape, and protein stability direct the natural selection of SARS-CoV-2 variants

(2021) Vaibhav Upadhyay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Limited Neutralization of Authentic Severe Acute Respiratory Syndrome Coronavirus 2 Variants Carrying E484K In Vitro

(2021) Marek Widera et al.   JOURNAL OF INFECTIOUS DISEASES

SARS-CoV-2 B.1.617 Mutations L452R and E484Q Are Not Synergistic for Antibody Evasion

(2021) Isabella A T M Ferreira et al.   JOURNAL OF INFECTIOUS DISEASES

Experimental Evidence for Enhanced Receptor Binding by Rapidly Spreading SARS-CoV-2 Variants

(2021) Charlie Laffeber et al.   JOURNAL OF MOLECULAR BIOLOGY

SARS-CoV-2 variants, spike mutations and immune escape

(2021) William T. Harvey et al.   NATURE REVIEWS MICROBIOLOGY

Insilico study on the effect of SARS-CoV-2 RBD hotspot mutants’ interaction with ACE2 to understand the binding affinity and stability

(2021) Jyoti Verma et al.   VIROLOGY

Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies

(2021) Marta Alenquer et al.   PLoS Pathogens

Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand the human ACE2 receptor on binding affinity and kinetics

(2021) Michael I Barton et al.   eLife

Epitope Classification and RBD Binding Properties of Neutralizing Antibodies Against SARS-CoV-2 Variants of Concern

(2021) Ashlesha Deshpande et al.   Frontiers in Immunology

The impact of spike N501Y mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent serum

(2021) Lu Lu et al.   EBioMedicine

Simultaneous evaluation of antibodies that inhibit SARS-CoV-2 variants via multiplex assay

(2021) Ester Lopez et al.   JCI Insight

SARS-CoV-2 Spike Mutations, L452R, T478K, E484Q and P681R, in the Second Wave of COVID-19 in Maharashtra, India

(2021) Sarah Cherian et al.   Microorganisms

Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants

(2021) Pengcheng Han et al.   Nature Communications

Molecular rationale for SARS-CoV-2 spike circulating mutations able to escape bamlanivimab and etesevimab monoclonal antibodies

(2021) Erik Laurini et al.   Scientific Reports

Battle against the pandemic: Emergence of SARS-CoV2 variants and global challenge

(2021) Saurabh Kumar et al.   Travel Medicine and Infectious Disease

Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants

(2021) Chunyan Yi et al.   Genome Medicine

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

(2020) Qihui Wang et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

Systemic effects of missense mutations on SARS-CoV-2 spike glycoprotein stability and receptor-binding affinity

(2020) Shaolei Teng et al.   BRIEFINGS IN BIOINFORMATICS

Variations in SARS-CoV-2 Spike Protein Cell Epitopes and Glycosylation Profiles During Global Transmission Course of COVID-19

(2020) Wenxin Xu et al.   Frontiers in Immunology

Evolutionary and structural analysis elucidates mutations on SARS-CoV2 spike protein with altered human ACE2 binding affinity

(2020) Sandipan Chakraborty   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In silico mutagenesis of human ACE2 with S protein and translational efficiency explain SARS-CoV-2 infectivity in different species

(2020) Javier Delgado Blanco et al.   PLoS Computational Biology

Structural Characterization of SARS-CoV-2: Where We Are, and Where We Need to Be

(2020) Giuseppina Mariano et al.   Frontiers in Molecular Biosciences

More bang for your buck: Improved use of GPU nodes for GROMACS 2018

(2019) Carsten Kutzner et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Structure, Function, and Evolution of Coronavirus Spike Proteins

(2016) Fang Li   Annual Review of Virology

g_wham—A Free Weighted Histogram Analysis Implementation Including Robust Error and Autocorrelation Estimates

(2010) Jochen S. Hub et al.   Journal of Chemical Theory and Computation

Improved side-chain torsion potentials for the Amber ff99SB protein force field

(2010) Kresten Lindorff-Larsen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS