In search for a synergistic combination against pandrug-resistant A. baumannii; methodological considerations

Interaction of Staphylococcus aureus and Acinetobacter baumannii during in vitro β-lactam exposure

(2021) Nicholas M. Smith et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Semi-mechanistic PK/PD modelling of fosfomycin and sulbactam combination against carbapenem-resistant Acinetobacter baumannii

(2021) S Mohd Sazlly Lim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evaluation of the Synergistic Antibacterial Effects of Fosfomycin in Combination with Selected Antibiotics against Carbapenem–Resistant Acinetobacter baumannii

(2021) Ozioma F. Nwabor et al.   Pharmaceuticals

Semi-mechanistic PK/PD modelling of meropenem and sulbactam combination against carbapenem-resistant strains of Acinetobacter baumannii

(2021) Sazlyna Mohd Sazlly Lim et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Widespread cefiderocol heteroresistance in carbapenem-resistant Gram-negative pathogens

(2021) Jacob E Choby et al.   LANCET INFECTIOUS DISEASES

The future of antibiotics begins with discovering new combinations

(2021) Meilin Zhu et al.   ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

Systematic review and meta-analysis of the proportion and associated mortality of polymicrobial (vs monomicrobial) pulmonary and bloodstream infections by Acinetobacter baumannii complex

(2021) Stamatis Karakonstantis et al.   INFECTION

Systematic Review of Antimicrobial Combination Options for Pandrug-Resistant Acinetobacter baumannii

(2021) Stamatis Karakonstantis et al.   Antibiotics-Basel

When Combined with Colistin, an Otherwise Ineffective Rifampicin–Linezolid Combination Becomes Active in Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii

(2020) Eva Armengol et al.   Microorganisms

Efficacy of ceftazidime-avibactam plus aztreonam in patients with bloodstream infections caused by MBL- producing Enterobacterales

(2020) Marco Falcone et al.   CLINICAL INFECTIOUS DISEASES

Re: ‘Colistin plus meropenem for carbapenem-resistant Gram-negative infections: in vitro synergism is not associated with better clinical outcomes’ by Nutman et al.

(2020) S. Karakonstantis   CLINICAL MICROBIOLOGY AND INFECTION

How preclinical infection models help define antibiotic doses in the clinic

(2020) Thomas Tängdén et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The efficacy of colistin monotherapy versus combination therapy with other antimicrobials against carbapenem-resistant Acinetobacter baumannii ST2 isolates

(2020) Jiaying Li et al.   JOURNAL OF CHEMOTHERAPY

Non-polymyxin based combinations as potential alternatives in treatment against carbapenem-resistant Acinetobacter baumannii infections

(2020) S Mohd Sazlly Lim et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Colistin heteroresistance in Acinetobacter spp.: systematic review and meta-analysis of the prevalence and discussion of the mechanisms and potential therapeutic implications

(2020) Stamatis Karakonstantis et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

A systematic review of implications, mechanisms, and stability of in vivo emergent resistance to colistin and tigecycline in Acinetobacter baumannii

(2020) Stamatis Karakonstantis   JOURNAL OF CHEMOTHERAPY

In vitro synergistic activity of the sulbactam/avibactam combination against extensively drug-resistant Acinetobacter baumannii

(2020) Carlos Hernán Rodriguez et al.   JOURNAL OF MEDICAL MICROBIOLOGY

A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumannii

(2020) Brian Luna et al.   Nature Microbiology

Treatment options for K. pneumoniae, P. aeruginosa and A. baumannii co-resistant to carbapenems, aminoglycosides, polymyxins and tigecycline: an approach based on the mechanisms of resistance to carbapenems

(2020) Stamatis Karakonstantis et al.   INFECTION

In vitro activity of rifabutin against 293 contemporary carbapenem-resistant Acinetobacter baumannii clinical isolates and characterization of rifabutin mode of action and resistance mechanisms

(2020) Vincent Trebosc et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Excess mortality due to pandrug-resistant Acinetobacter baumannii infections in hospitalized patients

(2020) S. Karakonstantis et al.   JOURNAL OF HOSPITAL INFECTION

Cefiderocol: the Trojan horse has arrived but will Troy fall?

(2020) Emily L Heil et al.   LANCET INFECTIOUS DISEASES

Pharmacodynamic Analysis of Meropenem and Fosfomycin Combination Against Carbapenem-Resistant Acinetobacter baumannii in Patients with Normal Renal Clearance: Can It Be a Treatment Option?

(2020) Sazlyna Mohd Sazlly Lim et al.   Microbial Drug Resistance

Efficacy of dual carbapenem treatment in a murine sepsis model of infection due to carbapenemase-producing Acinetobacter baumannii

(2020) T Cebrero-Cangueiro et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Synergistic activity of polymyxin B combined with vancomycin against carbapenem-resistant and polymyxin-resistant Acinetobacter baumannii: first in vitro study

(2019) Danielle Rosani Shinohara et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Drug repurposing for antimicrobial discovery

(2019) Maya A. Farha et al.   Nature Microbiology

Effect of rifampicin–colistin combination against XDR Acinetobacter baumannii harbouring blaOXA 23-like gene and showed reduced susceptibility to colistin at Cairo University Hospital, Cairo, Egypt

(2019) Doaa Ghaith et al.   Infectious Diseases

International Consensus Guidelines for the Optimal Use of the Polymyxins: Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti‐infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP)

(2019) Brian T. Tsuji et al.   PHARMACOTHERAPY

In-Vitro Evaluation of Different Antimicrobial Combinations with and without Colistin Against Carbapenem-Resistant Acinetobacter Baumannii

(2019) Alessandra Oliva et al.   MOLECULES

Synergy effect of Ceftazidime-Avibactam with Meropenem against pan-resistant Acinetobacter baumannii and Serratia marcescens harboring carbapenemases: time-kill and disk approximation assays

(2019) Juliana Januário Gaudereto et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Population pharmacokinetics and Monte Carlo simulations of sulbactam to optimize dosage regimens in patients with ventilator-associated pneumonia caused by Acinetobacter baumannii

(2019) Sutep Jaruratanasirikul et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

In vitro activity of eravacycline in combination with colistin against carbapenem-resistant A. baumannii isolates

(2019) H. Selcuk Ozger et al.   JOURNAL OF ANTIBIOTICS

Pharmacodynamic Effects of Sulbactam/Meropenem/Polymyxin-B Combination Against Extremely Drug Resistant Acinetobacter baumannii Using Checkerboard Information

(2019) Thatiany Cevallos Menegucci et al.   Microbial Drug Resistance

Mechanisms and clinical relevance of bacterial heteroresistance

(2019) Dan I. Andersson et al.   NATURE REVIEWS MICROBIOLOGY

Surprising synergy of dual translation inhibition vs. Acinetobacter baumannii and other multidrug-resistant bacterial pathogens

(2019) Nicholas Dillon et al.   EBioMedicine

When One Drug Is Not Enough

(2019) Thea Brennan-Krohn et al.   CLINICS IN LABORATORY MEDICINE

In-vitro evaluation of a dual carbapenem combination against carbapenemase-producing Acinetobacter baumannii

(2019) Patrice Nordmann et al.   JOURNAL OF INFECTION

Is Meropenem as a Monotherapy Truly Incompetent for Meropenem-Nonsusceptible Bacterial Strains? A Pharmacokinetic/Pharmacodynamic Modeling With Monte Carlo Simulation

(2019) Xiangqing Song et al.   Frontiers in Microbiology

Monitoring Ceftazidime-Avibactam and Aztreonam Concentrations in the Treatment of a Bloodstream Infection Caused by a Multidrug-Resistant Enterobacter sp. Carrying Both Klebsiella pneumoniae Carbapenemase–4 and New Delhi Metallo-β-Lactamase–1

(2019) Mohamad Yasmin et al.   CLINICAL INFECTIOUS DISEASES

Semi-mechanistic pharmacokinetic–pharmacodynamic modelling of antibiotic drug combinations

(2018) M.J.E. Brill et al.   CLINICAL MICROBIOLOGY AND INFECTION

Antimicrobial susceptibility testing of colistin – evaluation of seven commercial MIC products against standard broth microdilution for Escherichia coli , Klebsiella pneumoniae , Pseudomonas aeruginosa , and Acinetobacter spp.

(2018) E. Matuschek et al.   CLINICAL MICROBIOLOGY AND INFECTION

Antibiotic Hybrids: the Next Generation of Agents and Adjuvants against Gram-Negative Pathogens?

(2018) Ronald Domalaon et al.   CLINICAL MICROBIOLOGY REVIEWS

In vitro activities of carbapenems in combination with amikacin, colistin, or fosfomycin against carbapenem-resistant Acinetobacter baumannii clinical isolates

(2018) Uthaibhorn Singkham-in et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Letter to the Editor

(2018) Roy T Steigbigel et al.   CLINICAL INFECTIOUS DISEASES

Reply to Steigbigel

(2018) Noah Wald-Dickler et al.   CLINICAL INFECTIOUS DISEASES

In vitro evaluation of antimicrobial combinations against imipenem-resistant Acinetobacter baumannii of different MICs

(2018) Wan Zhu et al.   Journal of Infection and Public Health

Daptomycin as adjunctive treatment for experimental infection by Acinetobacter baumannii with resistance to colistin

(2018) Garyfallia Poulakou et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Pharmacokinetic-pharmacodynamic modelling to investigate in vitro synergy between colistin and fusidic acid against MDR Acinetobacter baumannii

(2018) Lynette M Phee et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

In Vitro Activities Of Ceftazidime/Avibactam Alone Or In Combination With Antibiotics Against Multi-Drug Resistant Acinetobacter baumannii Isolates

(2018) Emel MATARACI KARA et al.   Journal of Global Antimicrobial Resistance

Synergy against extensively drug-resistant Acinetobacter baumannii in vitro by two old antibiotics: colistin and chloramphenicol

(2017) Wen-juan Wei et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Polymyxin-resistant, carbapenem-resistant Acinetobacter baumannii is eradicated by a triple combination of agents that lack individual activity

(2017) Justin R. Lenhard et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Activity of levofloxacin in combination with colistin against Acinetobacter baumannii : In vitro and in a Galleria mellonella model

(2017) Wenjuan Wei et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Effect of appropriate combination therapy on mortality of patients with bloodstream infections due to carbapenemase-producing Enterobacteriaceae (INCREMENT): a retrospective cohort study

(2017) Belén Gutiérrez-Gutiérrez et al.   LANCET INFECTIOUS DISEASES

In VitroActivity of Fusidic Acid-Containing Combinations against Carbapenem-Resistant Acinetobacter baumannii Clinical Strains

(2016) Sarah L. Bowler et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroSynergistic Activity of Antimicrobial Agents in Combination against Clinical Isolates of Colistin-Resistant Acinetobacter baumannii

(2016) Seongman Bae et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Population pharmacokinetics and pharmacodynamics modeling to optimize dosage regimens of sulbactam in critically ill patients with severe sepsis caused byAcinetobacterbaumannii

(2016) Sutep Jaruratanasirikul et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VivoandIn VitroEfficacy of Minocycline-Based Combination Therapy for Minocycline-Resistant Acinetobacter baumannii

(2016) Ya-Sung Yang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vitro antimicrobial synergy of colistin with rifampicin and carbapenems against colistin-resistant Acinetobacter baumannii clinical isolates

(2016) Duck Jin Hong et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Strategies for the treatment of polymyxin B-resistant Acinetobacter baumannii infections

(2016) Thatiany Cevallos Menegucci et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Optimizing intravenous fosfomycin dosing in combination with carbapenems for treatment of Pseudomonas aeruginosa infections in critically ill patients based on pharmacokinetic/pharmacodynamic (PK/PD) simulation

(2016) O. Asuphon et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Determination of synergy between sulbactam, meropenem and colistin in carbapenem-resistantKlebsiella pneumoniaeandAcinetobacter baumanniiisolates and correlation with the molecular mechanism of resistance

(2016) Shakti Laishram et al.   JOURNAL OF CHEMOTHERAPY

Investigating the in vitro synergistic activities of several antibiotic combinationsagainst carbapenem-resistant Acinetobacter baumannii isolates

(2016) Sevim YAVAŞ et al.   Turkish Journal Of Medical Sciences

In VitroInteractions of Antibiotic Combinations of Colistin, Tigecycline, and Doripenem Against Extensively Drug-Resistant and Multidrug-ResistantAcinetobacter baumannii

(2016) Gyun Cheol Park et al.   Annals of Laboratory Medicine

Colistin and Fusidic Acid, a Novel Potent Synergistic Combination for Treatment of Multidrug-Resistant Acinetobacter baumannii Infections

(2015) Lynette M. Phee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Can Plazomicin Alone or in Combination Be a Therapeutic Option against Carbapenem-Resistant Acinetobacter baumannii?

(2015) Cristina García-Salguero et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroActivities of Novel Antimicrobial Combinations against Extensively Drug-Resistant Acinetobacter baumannii

(2015) J. Córdoba et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimicrobial Heteroresistance: an Emerging Field in Need of Clarity

(2015) Omar M. El-Halfawy et al.   CLINICAL MICROBIOLOGY REVIEWS

Synergistic interactions between colistin and meropenem against extensively drug-resistant and pandrug-resistant Acinetobacter baumannii isolated from ICU patients

(2015) S. Vourli et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

In vitro activity of minocycline alone or in combination in multidrug-resistant Acinetobacter baumannii isolates

(2015) Carlos Hernan Rodríguez et al.   JOURNAL OF MEDICAL MICROBIOLOGY

In vivoactivity of vancomycin combined with colistin against multidrug-resistant strains ofAcinetobacter baumanniiin aGalleriamellonellamodel

(2015) Haifei Yang et al.   Infectious Diseases

Determination of In Vitro Activities of Polymyxin B and Rifampin in Combination with Ampicillin/Sulbactam or Cefoperazone/Sulbactam against Multidrug-Resistant Acinetobacter baumannii by the E-test and Checkerboard Methods

(2015) Emel Sesli Cetin et al.   JAPANESE JOURNAL OF INFECTIOUS DISEASES

Sheltering Effect and Indirect Pathogenesis of Carbapenem-Resistant Acinetobacter baumannii in Polymicrobial Infection

(2014) Yu-Ting Liao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synergistic efficacy of meropenem and rifampicin in a murine model of sepsis caused by multidrug-resistant Acinetobacter baumannii

(2014) Yuan Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Colistin/daptomycin: an unconventional antimicrobial combination synergistic in vitro against multidrug-resistant Acinetobacter baumannii

(2014) Irene Galani et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Bacteriostatic versus bactericidal antibiotics for patients with serious bacterial infections: systematic review and meta-analysis

(2014) Johannes Nemeth et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

When Does 2 Plus 2 Equal 5? A Review of Antimicrobial Synergy Testing

(2014) C. D. Doern   JOURNAL OF CLINICAL MICROBIOLOGY

In vitro activity of rifampicin alone and in combination with imipenem against multidrug-resistant Acinetobacter baumannii harboring theblaOXA-72resistance gene

(2014) Piotr Majewski et al.   SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES

Antimicrobial activity of the imipenem/rifampicin combination against clinical isolates of Acinetobacter baumannii grown in planktonic and biofilm cultures

(2014) Yang Wang et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Activities of Vancomycin-Containing Regimens against Colistin-Resistant Acinetobacter baumannii Clinical Strains

(2013) Jessica A. O'Hara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synergistic Activity of Colistin and Rifampin Combination against Multidrug-Resistant Acinetobacter baumannii in anIn VitroPharmacokinetic/Pharmacodynamic Model

(2013) Hee Ji Lee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroResponses of Acinetobacter baumannii to Two- and Three-Drug Combinations following Exposure to Colistin and Doripenem

(2013) Louise M. Oleksiuk et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Assessment of the combination of doripenem plus a fluoroquinolone against non-susceptibleAcinetobacter baumanniiisolates from nosocomial pneumonia patients

(2013) Anne Marie Queenan et al.   JOURNAL OF CHEMOTHERAPY

Activity of the colistin–rifampicin combination against colistin-resistant, carbapenemase-producing Gram-negative bacteria

(2013) Marcela Nastro et al.   JOURNAL OF CHEMOTHERAPY

In Vitro Activity of Doripenem in Combination with Various Antimicrobials Against Multidrug-Resistant Acinetobacter baumannii: Possible Options for the Treatment of Complicated Infection

(2013) Luigi Principe et al.   Microbial Drug Resistance

In VitroSynergy of Colistin Combinations against Colistin-Resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae Isolates

(2012) Céline Vidaillac et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

N-acyl homoserine lactone mediated interspecies interactions between A. baumannii and P. aeruginosa

(2012) Nidhi Bhargava et al.   BIOFOULING

In vitroeffects of sulbactam combinations with different antibiotic groups against clinicalAcinetobacter baumanniiisolates

(2012) Aydin Deveci et al.   JOURNAL OF CHEMOTHERAPY

Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance

(2011) A.-P. Magiorakos et al.   CLINICAL MICROBIOLOGY AND INFECTION

Efficacy of rifampin, in monotherapy and in combinations, in an experimental murine pneumonia model caused by panresistant Acinetobacter baumannii strains

(2011) M. E. Pachón-Ibáñez et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

In vitro time-kill studies of antimicrobial agents against blood isolates of imipenem-resistant Acinetobacter baumannii, including colistin- or tigecycline-resistant isolates

(2011) Kyong Ran Peck et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

(2011) Linda Ejim et al.   Nature Chemical Biology

In Vitro Double and Triple Bactericidal Activities of Doripenem, Polymyxin B, and Rifampin against Multidrug-Resistant Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli

(2010) C. Urban et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroAntibiotic Synergy in Extensively Drug-ResistantAcinetobacter baumannii: the Effect of Testing by Time-Kill, Checkerboard, and Etest Methods

(2010) Thean Yen Tan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficacy of Rifampin and Its Combinations with Imipenem, Sulbactam, and Colistin in Experimental Models of Infection Caused by Imipenem-Resistant Acinetobacter baumannii

(2010) M. E. Pachon-Ibanez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Activity of doripenem with and without levofloxacin, amikacin, and colistin against Pseudomonas aeruginosa and Acinetobacter baumannii

(2010) Glenn A. Pankuch et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Synergistic activities between carbapenems and other antimicrobial agents against Acinetobacter baumannii including multidrug-resistant and extensively drug-resistant isolates

(2010) Pattarachai Kiratisin et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Quantitative Assessment of Combination Antimicrobial Therapy against Multidrug‐Resistant Bacteria in a Murine Pneumonia Model

(2010) Zhe Yuan et al.   JOURNAL OF INFECTIOUS DISEASES

In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones

(2010) Carlos Hernan Rodriguez et al.   Journal of Infection in Developing Countries

Pharmacokinetic–pharmacodynamic modeling to support doripenem dose regimen optimization for critically ill patients

(2009) Scott A. Van Wart et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

In vitro activity of various combinations of antimicrobials against carbapenem-resistant Acinetobacter species in Singapore

(2009) Tze-Peng Lim et al.   JOURNAL OF ANTIBIOTICS

In vitro activity of tigecycline in combination with various antimicrobials against multidrug resistant Acinetobacter baumannii

(2009) Luigi Principe et al.   Annals of Clinical Microbiology and Antimicrobials

Quantitative Assessment of Combination Antimicrobial Therapy against Multidrug-Resistant Acinetobacter baumannii

(2008) T.-P. Lim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficacy of monotherapy and combined antibiotic therapy for carbapenem-resistant Acinetobacter baumannii pneumonia in an immunosuppressed mouse model

(2008) Joon Young Song et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Antimicrobial Effects of Varied Combinations of Meropenem, Sulbactam, and Colistin on a Multidrug-Resistant Acinetobacter baumannii Isolate That Caused Meningitis and Bacteremia

(2008) Chen-Hsiang Lee et al.   Microbial Drug Resistance