Diving into the mechanism of action of tumor immunotherapies with intravital imaging*

Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis

(2021) Capucine L. Grandjean et al.   Science Advances

Functional heterogeneity of cytotoxic T cells and tumor resistance to cytotoxic hits limit anti‐tumor activity in vivo

(2021) Roxana Khazen et al.   EMBO JOURNAL

IFNg is Critical for CAR T Cell Mediated Myeloid Activation and Induction of Endogenous Immunity

(2021) Darya Alizadeh et al.   Cancer Discovery

A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity

(2021) Morgane Boulch et al.   Science Immunology

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity

(2021) Bettina Weigelin et al.   Nature Communications

Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity

(2019) Marine Cazaux et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chimeric Antigen Receptor Therapy

(2018) Carl H. June et al.   NEW ENGLAND JOURNAL OF MEDICINE

Past, Present, and Future of Rituximab—The World’s First Oncology Monoclonal Antibody Therapy

(2018) Timothy M. Pierpont et al.   Frontiers in Oncology

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

(2018) Christopher S. Garris et al.   IMMUNITY

In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy

(2017) Sean P. Arlauckas et al.   Science Translational Medicine

The PD-1 Axis Enforces an Anatomical Segregation of CTL Activity that Creates Tumor Niches after Allogeneic Hematopoietic Stem Cell Transplantation

(2016) David Michonneau et al.   IMMUNITY

In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity

(2016) Stephan Halle et al.   IMMUNITY

Intravital imaging reveals improved Kupffer cell-mediated phagocytosis as a mode of action of glycoengineered anti-CD20 antibodies

(2016) Capucine L. Grandjean et al.   Scientific Reports

Macrophages eliminate circulating tumor cells after monoclonal antibody therapy

(2014) Nuray Gül et al.   JOURNAL OF CLINICAL INVESTIGATION

The mechanism of anti-CD20–mediated B cell depletion revealed by intravital imaging

(2013) Fabricio Montalvao et al.   JOURNAL OF CLINICAL INVESTIGATION

Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

(2012) Hélène Salmon et al.   JOURNAL OF CLINICAL INVESTIGATION

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Decade of Imaging Cellular Motility and Interaction Dynamics in the Immune System

(2012) R. N. Germain et al.   SCIENCE

Brief Report: Intravital Imaging of Cancer Stem Cell Plasticity in Mammary Tumors

(2012) Anoek Zomer et al.   STEM CELLS

Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias

(2011) R. J. Brentjens et al.   BLOOD

Graft-versus-host disease

(2009) James LM Ferrara et al.   LANCET

Choreography of Cell Motility and Interaction Dynamics Imaged by Two-Photon Microscopy in Lymphoid Organs

(2008) Michael D. Cahalan et al.   Annual Review of Immunology