Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 159, Issue 6, Pages 740-742Publisher
SPRINGER
DOI: 10.1007/s10517-015-3063-x
Keywords
cholinergic anti-inflammatory pathway; sepsis; alpha 7n-acetylcholine receptors; antibodies to TNF-alpha; proinflammatory cytokines
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Experiments on random-bred albino mice showed that activation alpha 7n-acetylcholine receptors with anabasine (0.5 LD50) and the use of antibodies to TNF-alpha (1 mg/kg) 2 h before sepsis modeling significantly reduces mortality of mice from experimental sepsis (intraperitoneal injection of E. coli) due to a decrease in the blood concentration of proinflammatory cytokines TNF-alpha, IL-1 beta, and IL-6. After combined administration of anti-TNF-alpha antibodies and anabasine, an additive effect was observed.
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